Personalized Medicine for Post COVID and Long COVID

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 15 September 2024 | Viewed by 3580

Special Issue Editor


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Guest Editor
1. Pulmonary Dept of First ICU Clinic, Evangelismos Hospital, 10676 Athens, Greece
2. School of Medicine, National and Kapodistrian University of Athens, 10561 Athens, Greece
Interests: infections; COVID-19; smoking cessation; asthma; ergospirometry
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Special Issue Information

Dear Colleagues,

The COVID pandemic has been followed by a second pandemic caused by significant COVID complications. According to the last WHO declaration, long COVID is defined as the continuation or development of new symptoms three months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. Long COVID can affect anyone exposed to SARS-CoV-2, regardless of age or the severity of the original symptoms. While common symptoms of long COVID can include fatigue, shortness of breath and cognitive dysfunction, over 200 different symptoms have been reported that can have an impact on everyday functioning.

Long COVID occurs in 10–20% of people infected by SARS-CoV-2. More than 200 symptoms have been reported, with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Progress has been made in identifying the pathophysiological mechanisms of long COVID, but much research is still needed in the field. This Special Issue seeks research papers on various aspects related to the emerging topic of long COVID such as key findings, overlap with other conditions, onset of symptoms, impact of vaccinations, diagnostic plans, pharmaceutical approaches and rehabilitation programs. Long COVID public health impacts and patient organisations are also within the scope of this issue, as it is important to engage patients throughout the research process.

We especially encourage the submission of interdisciplinary works and multi-country collaborative research. We welcome submissions of original research papers using different study designs and critical and relevant reviews, including systematic reviews.

Dr. Paraskevi Katsaounou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • long COVID
  • fatigue
  • post COVID
  • dyspnea
  • cognitive dysfunction

Published Papers (3 papers)

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Research

11 pages, 282 KiB  
Article
Assessment of Dyspnoea, Physical Activity, and Back Pain Levels in Students at Medical Universities after the COVID-19 Pandemic in Poland
by Monika Gałczyk, Anna Zalewska and Marek Sobolewski
J. Pers. Med. 2023, 13(10), 1474; https://doi.org/10.3390/jpm13101474 - 8 Oct 2023
Viewed by 902
Abstract
Objectives: The purpose of this research was to assess the extent of dyspnoea, physical activity (PA), and back pain complaints and the association of dyspnoea, PA, and back pain complaints with PA in post-COVID-19 students at medical universities in Poland. Methods: An online [...] Read more.
Objectives: The purpose of this research was to assess the extent of dyspnoea, physical activity (PA), and back pain complaints and the association of dyspnoea, PA, and back pain complaints with PA in post-COVID-19 students at medical universities in Poland. Methods: An online survey was carried out among Polish medical students (213 women and 204 men) who had had a positive test for SARS-CoV-2 within the last year. The Medical Research Council (MRC) dyspnoea scale was used to assess the degree of dyspnoea. The International Physical Activity Questionnaire (IPAQ) was used to determine the level of PA. The Oswestry Disability Index (ODI) and the Neck Disability Index (NDI) were used to assess back discomfort. Results: The study group had average levels of PA, with median total activity significantly lower in women (median total activity for women was 1189 and for men was 2044, while the standard deviation for women was 1419 and for men was 1450). More than 93% of the students reported no symptoms of dyspnoea. The following results were observed for ODI (median of 1.2 for women and 1.7 for men and standard deviation of 3.1 for women and 4.0 for men) and for NDI (median of 2.8 for women and 2.5 for men, standard deviation of 4.3 for women and 4.0 for men). Cervical spine pain was more frequent and severe. There are small, statistically significant correlations between the MRC and IPAQ measures and the ODI and NDI and IPAQ. Conclusions: In the study group of students of medicine, dyspnoea linked with a history of COVID-19 is not an issue. Post-pandemic PA levels should be increased in this group, with particular attention to female students. Urgent measures are also needed to prevent cervical pain in students at medical universities in Poland. Full article
(This article belongs to the Special Issue Personalized Medicine for Post COVID and Long COVID)
10 pages, 278 KiB  
Article
Fatigue and Physical Activity in People after COVID-19 in Poland
by Anna Zalewska and Monika Gałczyk
J. Pers. Med. 2023, 13(9), 1369; https://doi.org/10.3390/jpm13091369 - 11 Sep 2023
Viewed by 791
Abstract
Objectives: The purpose of this research was to look at the amount of fatigue and physical activity (PA) in individuals after COVID-19 in Poland and the correlation between fatigue and PA. Methods: The online research was carried out among adult Polish residents (122 [...] Read more.
Objectives: The purpose of this research was to look at the amount of fatigue and physical activity (PA) in individuals after COVID-19 in Poland and the correlation between fatigue and PA. Methods: The online research was carried out among adult Polish residents (122 women and 82 men) who had tested positive for SARS-CoV-2 during the previous year. The level of fatigue was measured using the Modified Fatigue Impact Scale (MFIS). The PA level was assessed using the International Physical Activity Questionnaire (IPAQ). Results: A total of 46.6% of the subjects had been ill with COVID-19 for more than 6 months before the time of the survey response. The MFIS total measure is 77 of the maximum score, and the median is 17. A total of 26% of respondents reported low activity, while 41% of respondents reported high activity. A statistically significant negative relationship was found between PA level and total fatigue score. The best scores for fatigue and PA were obtained by the subjects with mild COVID-19. The time since diagnosis (as opposed to older age and female sex) was not clearly associated with most measures. Conclusions: PA may play an important role in regulating the severity of fatigue; it should be increased, especially in patients after COVID. Further studies are also needed to investigate the mechanism of differences in fatigue and PA. Full article
(This article belongs to the Special Issue Personalized Medicine for Post COVID and Long COVID)
14 pages, 1357 KiB  
Article
Persistent Endothelial Lung Damage and Impaired Diffusion Capacity in Long COVID
by Andreas T. Asimakos, Alice G. Vassiliou, Chrysi Keskinidou, Stavroula Spetsioti, Archontoula Antonoglou, Charikleia S. Vrettou, Panagiotis Mourelatos, Aristidis Diamantopoulos, Maria Pratikaki, Nikolaos Athanasiou, Edison Jahaj, Parisis Gallos, Anastasia Kotanidou, Ioanna Dimopoulou, Stylianos E. Orfanos and Paraskevi Katsaounou
J. Pers. Med. 2023, 13(9), 1351; https://doi.org/10.3390/jpm13091351 - 31 Aug 2023
Viewed by 999
Abstract
Since the beginning of the pandemic, both COVID-19-associated coagulopathy biomarkers and a plethora of endothelial biomarkers have been proposed and tested as prognostic tools of severity and mortality prediction. As the pandemic is gradually being controlled, attention is now focusing on the long-term [...] Read more.
Since the beginning of the pandemic, both COVID-19-associated coagulopathy biomarkers and a plethora of endothelial biomarkers have been proposed and tested as prognostic tools of severity and mortality prediction. As the pandemic is gradually being controlled, attention is now focusing on the long-term sequelae of COVID-19. In the present study, we investigated the role of endothelial activation/dysfunction in long COVID syndrome. This observational study included 68 consecutive long COVID patients and a healthy age and sex-matched control group. In both groups, we measured 13 endothelial biomarkers. Moreover, in the long COVID patients, we evaluated fatigue and dyspnea severity, lung diffusion capacity (DLCO), and the 6-min walk (6MWT) test as measures of functional capacity. Our results showed that markers of endothelial activation/dysfunction were higher in long COVID patients, and that soluble intracellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1 (sVCAM-1) negatively correlated with lung diffusion and functional capacity (sICAM-1 vs. DLCO, r = −0.306, p = 0.018; vs. 6MWT, r = −0.263, p = 0.044; and sVCAM-1 vs. DLCO, r= −0.346, p = 0.008; vs. 6MWT, r = −0.504, p < 0.0001). In conclusion, evaluating endothelial biomarkers alongside clinical tests might yield more specific insights into the pathophysiological mechanisms of long COVID manifestations. Full article
(This article belongs to the Special Issue Personalized Medicine for Post COVID and Long COVID)
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