Special Issue "Development in Early Life Periods and Chronic Diseases in Fetal/Neonate Origins"

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 1179

Special Issue Editor

1. Maternal and Child Health Care Hospital of Wuxi, Wuxi, China
2. First Hospital of Soochow University, Suzhou, China
Interests: fetal medicine; developmental physiology; placenta-related diseases; cardiovascular diseases in fetal origins

Special Issue Information

Dear Colleagues,

Progress has been made in the last three to four decades in the demonstration of the fact that many chronic diseases, including hypertension, stroke, diabetes, and tumors, could be initially imprinted during fetal or neonate stages due to various adverse factors. Pathophysiological, molecular, and epigenetic mechanisms have been intensively explored to explain why and how environmental, maternal, or in utero conditions such as lifestyles, food intake, maternal stress, and pollution can impact health and diseases in the offspring. These kinds of perinatal influence could have a long-term impact on cardiovascular, immune, nervous, and other systems or organs, affecting the health of not only young adults but also old offspring. In those affected babies or neonates, in the womb or after birth, there are no obvious anatomy defects. However, during their development from baby to adult, perinatal imprinting or subtle changes, including functional and molecular alterations due to adverse factors, may show their effects through an increased risk in the development of various chronic diseases in adulthood. On other side, the progress of research in adult diseases of developmental origins also continuously provides novel information and new mechanisms for many chronic diseases, which has opened opportunities for precision medicine and personalized medicine, as well as personalized early prevention of certain chronic diseases of developmental origins. Thus, this Special Issue of JPM welcomes manuscripts on etiology, pathophysiology, and molecular biology related to “Developmental origins of Health and Diseases (DOHaD)” in both human and animal models.

Prof. Dr. Zhice Xu
Guest Editor

Manuscript Submission Information

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  • fetal/neonate development
  • developmental origins of health and diseases (DOHaD)
  • chronic diseases
  • perinatal adverse factors
  • in utero alterations
  • epigenetic regulations

Published Papers (1 paper)

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Long-Term Impact of the Great Chinese Famine on the Risks of Specific Arrhythmias and Severe Hypertension in the Offspring at an Early Stage of Aging
J. Pers. Med. 2023, 13(2), 163; https://doi.org/10.3390/jpm13020163 - 17 Jan 2023
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Perinatal malnutrition affects postnatal cardiovascular functions. This study used the Great Chinese Famine (GCF) to determine the long-term impact of perinatal undernutrition on hypertension and arrhythmias in older offspring. Subjects (n = 10,065) were divided into an exposed group whose fetal life [...] Read more.
Perinatal malnutrition affects postnatal cardiovascular functions. This study used the Great Chinese Famine (GCF) to determine the long-term impact of perinatal undernutrition on hypertension and arrhythmias in older offspring. Subjects (n = 10,065) were divided into an exposed group whose fetal life was in the GCF and an unexposed group. The exposed group showed higher systolic/diastolic pressure, heart rate, and total cholesterol. Perinatal exposure to the GCF was a significant risk to Grade 2 and Grade 3 hypertension (OR = 1.724, 95%CI: 1.441–2.064, p < 0.001; OR = 1.480, 95%CI: 1.050–2.086, p < 0.05) compared to the control. The GCF also increased risks for myocardial ischemia (OR = 1.301, 95%CI: 1.135–1.490, p < 0.001), bradycardia (OR = 1.383, 95%CI: 1.154–1.657, p < 0.001), atrial fibrillation (OR = 1.931, 95%CI: 1.033–3.610, p < 0.05), and atrioventricular block (OR = 1.333, 95%CI: 1.034–1.719, p < 0.05). Total cholesterol, diabetes, and metabolic syndrome were associated with Grade 2 or Grade 3 hypertension after exposure to the GCF; high cholesterol, high BMI, diabetes, metabolic syndrome, and elevated blood pressure were linked to certain types of arrhythmias in exposed offspring. The results first demonstrated perinatal undernutrition was a significant risk factor for the development of Grade 2–3 hypertension and certain arrhythmias in humans. Perinatal undernutrition still significantly impacted cardiovascular systems of the aged offspring even 50 years after the GCF. The results also provided information to a specific population with a history of prenatal undernutrition for early prevention against cardiovascular diseases before aging. Full article
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