Dear Colleagues,

Progress has been made in the last three to four decades in the demonstration of the fact that many chronic diseases, including hypertension, stroke, diabetes, and tumors, could be initially imprinted during fetal or neonate stages due to various adverse factors. Pathophysiological, molecular, and epigenetic mechanisms have been intensively explored to explain why and how environmental, maternal, or in utero conditions such as lifestyles, food intake, maternal stress, and pollution can impact health and diseases in the offspring. These kinds of perinatal influence could have a long-term impact on cardiovascular, immune, nervous, and other systems or organs, affecting the health of not only young adults but also old offspring. In those affected babies or neonates, in the womb or after birth, there are no obvious anatomy defects. However, during their development from baby to adult, perinatal imprinting or subtle changes, including functional and molecular alterations due to adverse factors, may show their effects through an increased risk in the development of various chronic diseases in adulthood. On other side, the progress of research in adult diseases of developmental origins also continuously provides novel information and new mechanisms for many chronic diseases, which has opened opportunities for precision medicine and personalized medicine, as well as personalized early prevention of certain chronic diseases of developmental origins. Thus, this Special Issue of JPM welcomes manuscripts on etiology, pathophysiology, and molecular biology related to “Developmental origins of Health and Diseases (DOHaD)” in both human and animal models.

Prof. Dr. Zhice Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• fetal/neonate development
• developmental origins of health and diseases (DOHaD)
• chronic diseases
• perinatal adverse factors
• in utero alterations
• epigenetic regulations