Submit to Special Issue Submit Abstract to Special Issue Review for JPM Propose a Special Issue

Journal Menu

Journal Browser

Special Issue "New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training"

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 6692

Share This Special Issue

Special Issue Editors

Dr. Luca Ricciardi

E-Mail Website1 Website2
Guest Editor

Department of Neuroscience, Mental Health and Sense Organs NESMOS, Sapienza University of Rome, Rome, Italy
Interests: brain tumor; brain Injury; spine disorders; spinal surgery;

Dr. Tamara Ius

E-Mail Website
Guest Editor

Neurosurgery Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy
Interests: neurosurgery; glioma; meningioma; glioblastoma; brain mapping; real-time neuropsychological testing; brain tractography
Special Issues, Collections and Topics in MDPI journals

Dr. Federico Nicolosi

E-Mail Website
Guest Editor

Department of Medicine and Surgery, Division of Neurosurgery, University of Milano-Bicocca, Milan, Italy
Interests: neurosurgery; neuroanatomy; training; vascular; aneurysms; AVM; augmented reality; innovations in neurosurgery; neuro endoscopy; skull base; neuro oncology; brain tumors

Special Issue Information

Dear Colleagues,

Neurosurgery, as a leading innovative neuroscience in medicine, is progressively including the latest technological evolutions, such as magnification devices, neuro-navigation, augmented reality, intraoperative neurophysiological monitoring, and training tools.

The aim of the present issue is to collect papers on emerging strategies, surgical techniques, technologies, and therapeutic protocols for managing the different neurosurgical conditions and training younger physicians.

Cutting-edge research includes:

Immuno- and targeted therapy-based protocols in neuro-oncology;
Novel techniques or instrumentations for minimally invasive spine surgery;
Emerging technologies or innovations in neurosurgery;
Neurosurgical training tools or protocols for residents, fellows, and younger physicians.

Papers reporting clinical protocols, surgical techniques, management strategies, medical or surgical alternatives to standard treatment even in properly selected patients’ subgroups, and training projects to improve the skills of residents or fellows will be considered for publication.

Dr. Luca Ricciardi
Dr. Tamara Ius
Dr. Federico Nicolosi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

neurosurgery
spine
neuro-oncology
frontiers
personalized medicine
education and training

Published Papers (5 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

16 pages, 617 KiB

Open AccessArticle

Meningioma-Related Epilepsy: A Happy Ending?

and

J. Pers. Med. 2023, 13(7), 1124; https://doi.org/10.3390/jpm13071124 - 11 Jul 2023

Viewed by 1303

Abstract

(1) Background: More than one-third of patients with meningiomas experience at least one seizure during the course of their disease, and in the 20–50% of cases, seizure represents the onset symptom. After surgery, up to 30% of patients continue to have seizures, while others may experience them later; (2) Methods: The study analyzed retrospectively the risk factors for pre-operative seizures in a large cohort of 358 patients who underwent surgery for newly diagnosed brain meningioma; (3) Results: We identified age, peritumor edema, and location as risk factors for seizure at the onset. Patients with seizures differed from patients without seizures for the following characteristics: younger average age, lower pre-operative Karnofsky Performance Status (KPS), location on the convexity, lower Simpson Grade, lower incidence of pre-operative neurological deficits, and higher incidence of pre-operative peritumor edema. After 24 months, 88.2% of patients were classified as Engel class Ia, and no correlation with disease progression was observed; (4) Conclusions: Meningioma-related epilepsy has generally a positive outcome following surgery and it seems not to be linked to disease progression, even if further studies are needed. Full article

(This article belongs to the Special Issue New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training)

► Show Figures

Graphical abstract

11 pages, 264 KiB

Open AccessArticle

Clinical-Epidemiology of Tension-Type Headache among the Medical and Dental Undergraduates of King Khalid University, Abha, Saudi Arabia

Zia Ul Sabah

Shahid Aziz

Bayapa Reddy Narapureddy

Hassan Ahmed A. Alasiri

Hassan Yahya M. Asiri

Abdulkhaliq Hadi H. Asiri

Ahmad Abdullah H. Alsulami

Nawaf Khalid Ahmad Hassan

Shaik Mohammed Asif

and

Shmookh Mohsen Alsyd

J. Pers. Med. 2022, 12(12), 2064; https://doi.org/10.3390/jpm12122064 - 14 Dec 2022

Cited by 1 | Viewed by 1256

Abstract

Introduction (background): Headache is the primary complaint among students. Headaches mostly have multifactorial causes. The degree of headache severity significantly impacts attitudes, behavior, and academic performance. Objectives: Here, we investigate the demographic epidemiology of tension-type headaches (T.T.H.), and determine the clinical presentation and triggers of the tension-type among headache sufferers. Methods (settings, design): An institutional-based cross-sectional study (descriptive) was conducted on the medical and dental undergraduates at King Khalid University, Abha, Saudi Arabia, from 1 July 2021 to 31 December 2021. Data were gathered using a pre-designed questionnaire. A consecutive sampling method was used in a COVID-19-constrained environment. After preliminary screening of the study population, 460 samples were included. An electronic questionnaire was shared with them, and they were requested to respond. Results: More than half of the participants (258, 56.1%) experienced tension-type headaches, while the remaining 202 (43.9%) never felt a headache. Tension-type headaches manifested as heaviness of the head (44, 17.0%), tightness (126, 48.8%), and dull aching pain (66, 25.7%). Conclusions: T.T.H. is a prevalent condition with a significant impingement on academic work, and psychological health. Tension-type headache sufferers are advised to keep daily diaries to determine triggers, and plan for prevention and treatment progression. Full article

(This article belongs to the Special Issue New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training)

16 pages, 2455 KiB

Open AccessArticle

Psychiatric Symptoms in Parkinson’s Disease Patients before and One Year after Subthalamic Nucleus Deep Brain Stimulation Therapy: Role of Lead Positioning and Not of Total Electrical Energy Delivered

Andrea De Bartolomeis

Paolo Cappabianca

and

Giordano D’Urso

J. Pers. Med. 2022, 12(10), 1643; https://doi.org/10.3390/jpm12101643 - 03 Oct 2022

Cited by 2 | Viewed by 1134

Abstract

Parkinson’s disease (PD) patients may experience neuropsychiatric symptoms, including depression, anxiety, sleep disturbances, psychosis, as well as behavioral and cognitive symptoms during all the different stages of the illness. Deep Brain Stimulation (DBS) therapy has proven to be successful in controlling the motor symptoms of PD and its possible correlation with the occurrence or worsening of neuropsychiatric symptoms has been reported. We aimed to assess the neuropsychiatric symptoms of 14 PD patients before and after one year of Subthalamic Nucleus (STN)-DBS and to correlate the possible changes to the lead placement and to the total electrical energy delivered. We assessed PD motor symptoms, depression, anxiety, apathy, impulsivity, and suicidality using clinician- and/or self-administered rating scales and correlated the results to the lead position using the Medtronic SuretuneTM software and to the total electrical energy delivered (TEED). At the 12-month follow-up, the patients showed a significant improvement in PD symptoms on the UPDRS (Unified Parkinson’s disease Rating Scale) (−38.5%; p < 0.001) and in anxiety on the Hamilton Anxiety Rating Scale (HAM-A) (−29%; p = 0.041), with the most significant reduction in the physiological anxiety subscore (−36.26%; p < 0.001). A mild worsening of impulsivity was detected on the Barratt Impulsiveness Scale (BIS-11) (+9%; p = 0.048), with the greatest increase in the attentional impulsiveness subscore (+13.60%; p = 0.050). No statistically significant differences were found for the other scales. No correlation was found between TEED and scales’ scores, while the positioning of the stimulating electrodes in the different portions of the STN was shown to considerably influence the outcome, with more anterior and/or medial lead position negatively influencing psychiatric symptoms. Full article

(This article belongs to the Special Issue New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training)

► Show Figures

Figure 1

11 pages, 267 KiB

Open AccessArticle

Does the Timing of the Surgery Have a Major Role in Influencing the Outcome in Elders with Acute Subdural Hematomas?

and

Carmelo Lucio Sturiale

J. Pers. Med. 2022, 12(10), 1612; https://doi.org/10.3390/jpm12101612 - 30 Sep 2022

Cited by 1 | Viewed by 1063

Abstract

Background: The incidence of traumatic acute subdural hematomas (ASDH) in the elderly is increasing. Despite surgical evacuation, these patients have poor survival and low rate of functional outcome, and surgical timing plays no clear role as a predictor. We investigated whether the timing of surgery had a major role in influencing the outcome in these patients. Methods: We retrospectively retrieved clinical and radiological data of all patients ≥70 years operated on for post-traumatic ASDH in a 3 year period in five Italian hospitals. Patients were divided into three surgical timing groups from hospital arrival: ultra-early (within 6 h); early (6–24 h); and delayed (after 24 h). Outcome was measured at discharge using two endpoints: survival (alive/dead) and functional outcome at the Glasgow Outcome Scale (GOS). Univariate and multivariate predictor models were constructed. Results: We included 136 patients. About 33% died as a result of the consequences of ASDH and among the survivors, only 24% were in good functional outcome at discharge. Surgical timing groups appeared different according to presenting the Glasgow Outcome Scale (GCS), which was on average lower in the ultra-early surgery group, and radiological findings, which appeared worse in the same group. Delayed surgery was more frequent in patients with subacute clinical deterioration. Surgical timing appeared to be neither associated with survival nor with functional outcome, also after stratification for preoperative GCS. Preoperative midline shift was the strongest outcome predictor. Conclusions: An earlier surgery was offered to patients with worse clinical-radiological findings. Additionally, after stratification for GCS, it was not associated with better outcome. Among the radiological markers, preoperative midline shift was the strongest outcome predictor. Full article

(This article belongs to the Special Issue New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training)

Review

Jump to: Research

15 pages, 2057 KiB

Open AccessReview

The Potential Role of Dysregulated miRNAs in Adolescent Idiopathic Scoliosis and 22q11.2 Deletion Syndrome

and

J. Pers. Med. 2022, 12(11), 1925; https://doi.org/10.3390/jpm12111925 - 18 Nov 2022

Cited by 4 | Viewed by 1250

Abstract

Background: Adolescent idiopathic scoliosis (AIS), affecting 2–4% of adolescents, is a multifactorial spinal disease. Interactions between genetic and environmental factors can influence disease onset through epigenetic mechanisms, including DNA methylation, histone modifications and miRNA expression. Recent evidence reported that, among all clinical features in individuals with 22q11.2 deletion syndrome (DS), scoliosis can occur with a higher incidence than in the general population. Methods: A PubMed and Ovid Medline search was performed for idiopathic scoliosis in the setting of 22q11.2DS and miRNA according to PRISMA guidelines. Results: Four papers, accounting for 2841 individuals, reported clinical data about scoliosis in individuals with 22q11.2DS, showing that approximately 35.1% of the individuals with 22q11.2DS developed scoliosis. Conclusions: 22q11.2DS could be used as a model for the study of AIS. The DGCR8 gene seems to be essential for microRNA biogenesis, which is why we propose that a possible common pathological mechanism between scoliosis and 22q11.2DS could be the dysregulation of microRNA expression. In the current study, we identified two miRNAs that were altered in both 22q11.2DS and AIS, miR-93 and miR-1306, thus, corroborating the hypothesis that the two diseases share common molecular alterations. Full article

(This article belongs to the Special Issue New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training)

► Show Figures

Journal Menu

Journal Browser

Special Issue "New Trends in Neurooncology, Neurosurgery, and Neurosurgical Training"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (5 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI