Special Issue "Histiocytic Disorders of the Lung: Updates in Diagnosis, Molecular Alterations, and Novel Therapeutics Options"

A special issue of Journal of Respiration (ISSN 2673-527X).

Deadline for manuscript submissions: 1 March 2024 | Viewed by 100

Special Issue Editor

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Interests: hematolymphoid tumors; thoracic/lung pathology; mediastinal lymphomas; the correlation between morphology and molecular alterations of tumors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although rare, histiocytic disorders may affect the lung in the form of either a primary or secondary disease. These disorders include Langerhans cell histiocytosis; Erdheim–Chester disease; Rosai–Dorfman disease; juvenile xanthogranuloma; crystal-storing histiocytosis; as well as other less well-known entities, such as ALK+ or NTRK+ histiocytosis/histiocytic tumors. Once considered reactive proliferations, several studies published within the last two decades have shown that at least a subset of these disorders are clonal- and/or harbor-specific molecular alterations that may translate into potential therapeutic targets, such as with the detection of recurrent genetic alterations in molecules involved in the activation of the RAS/RAF/MAPK signaling pathway. This Special Issue is dedicated to the study of current and emerging tools in the diagnostic armamentarium of pulmonary histiocytic disorders as well as to novel and promising therapeutic approaches, including the use of molecularly targeted therapies.

Dr. Sergio Piña-Oviedo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Respiration is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • histiocytosis
  • diagnostics
  • pulmonary langerhans cell histiocytosis
  • Erdheim–Chester disease
  • extranodal Rosai–Dorfman disease
  • crystal-storing histiocytosis
  • juvenile xanthogranuloma
  • BRAF V600E
  • targeted therapy

Published Papers

This special issue is now open for submission.
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