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Morphological Development of Candida
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Morphological Development of Candida

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2613

Special Issue Editor

Dr. Jia-Ching Shieh

E-Mail Website
Guest Editor
1. Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 40201, Taiwan
2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
3. Immunology Research Center, Chung Shan Medical University, Taichung City 40201, Taiwan
Interests: Candida albicans; morphological plasticity; microbial molecular biology; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Candida albicans is an opportunistic human fungal pathogen. It usually inhabits a human host as a commensal organism but can cause life-threatening infections. The molecular mechanism underlying C. albicans morphological development is vital as it ties with virulence. Notably, an eminent number of virulence genes is co-regulated with morphogenesis, highlighting that C. albicans commensalism and pathogenesis lie in the development programs of multimorphism. While genetics and epigenetics play a role in C. albicans morphogenesis, switching among diverse morphological forms is influenced by many environmental factors, which trigger various signaling pathways and lead to alteration of many cellular functions. Other Candida species present morphogenesis traits common or unique to C. albicans. Understanding the morphological development in Candida is essential to fight against Candida infection.

This SI intends to present new data on morphological development of Candida albicans and other Candida species. Original articles and reviews are welcome.

Dr. Jia-Ching Shieh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Candida
  • morphological development
  • morphogenesis
  • genetics
  • epigenetics
  • environmental factors
  • signaling pathways

Published Papers (2 papers)

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Research

19 pages, 8655 KiB  
Article
The Early Endocytosis Gene PAL1 Contributes to Stress Tolerance and Hyphal Formation in Candida albicans
by Miranda Yu, Dakota Ma, Susan Eszterhas, Christiane Rollenhagen and Samuel A. Lee
J. Fungi 2023, 9(11), 1097; https://doi.org/10.3390/jof9111097 - 10 Nov 2023
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Abstract
The endocytic and secretory pathways of the fungal pathogen Candida albicans are fundamental to various key cellular processes such as cell growth, cell wall integrity, protein secretion, hyphal formation, and pathogenesis. Our previous studies focused on several candidate genes involved in early endocytosis, [...] Read more.
The endocytic and secretory pathways of the fungal pathogen Candida albicans are fundamental to various key cellular processes such as cell growth, cell wall integrity, protein secretion, hyphal formation, and pathogenesis. Our previous studies focused on several candidate genes involved in early endocytosis, including ENT2 and END3, that play crucial roles in such processes. However, much remains to be discovered about other endocytosis-related genes and their contributions toward Candida albicans secretion and virulence. In this study, we examined the functions of the early endocytosis gene PAL1 using a reverse genetics approach based on CRISPR-Cas9-mediated gene deletion. Saccharomyces cerevisiae Pal1 is a protein in the early coat complex involved in clathrin-mediated endocytosis that is later internalized with the coat. The C. albicans pal1Δ/Δ null mutant demonstrated increased resistance to the antifungal agent caspofungin and the cell wall stressor Congo Red. In contrast, the null mutant was more sensitive to the antifungal drug fluconazole and low concentrations of SDS than the wild type (WT) and the re-integrant (KI). While pal1Δ/Δ can form hyphae and a biofilm, under some hyphal-inducing conditions, it was less able to demonstrate filamentous growth when compared to the WT and KI. The pal1Δ/Δ null mutant had no defect in clathrin-mediated endocytosis, and there were no changes in virulence-related processes compared to controls. Our results suggest that PAL1 has a role in susceptibility to antifungal agents, cell wall integrity, and membrane stability related to early endocytosis. Full article
(This article belongs to the Special Issue Morphological Development of Candida)
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15 pages, 2071 KiB  
Article
The Cdc25 and Ras1 Proteins of Candida albicans Influence Epithelial Toxicity in a Niche-Specific Way
by Stefanie Wijnants, Jolien Vreys, Jana Nysten and Patrick Van Dijck
J. Fungi 2023, 9(2), 201; https://doi.org/10.3390/jof9020201 - 04 Feb 2023
Viewed by 1357
Abstract
The PKA pathway is a signaling pathway involved in virulence in Candida albicans. This mechanism can be activated via addition of glucose and activation involves at least two proteins, namely Cdc25 and Ras1. Both proteins are involved in specific virulence traits. However, [...] Read more.
The PKA pathway is a signaling pathway involved in virulence in Candida albicans. This mechanism can be activated via addition of glucose and activation involves at least two proteins, namely Cdc25 and Ras1. Both proteins are involved in specific virulence traits. However, it is not clear if Cdc25 and Ras1 also affect virulence independently of PKA. C. albicans holds a second, atypical, Ras protein, Ras2, but its function in PKA activation is still unclear. We investigated the role of Cdc25, Ras1, and Ras2 for different in vitro and ex vivo virulence characteristics. We show that deletion of CDC25 and RAS1 result in less toxicity towards oral epithelial cells, while deletion of RAS2 has no effect. However, toxicity towards cervical cells increases in both the ras2 and the cdc25 mutants while it decreases in a ras1 mutant compared to the WT. Toxicity assays using mutants of the transcription factors downstream of the PKA pathway (Efg1) or the MAPK pathway (Cph1) show that the ras1 mutant shows similar phenotypes as the efg1 mutant, whereas the ras2 mutant shows similar phenotypes as the cph1 mutant. These data show niche-specific roles for different upstream components in regulating virulence through both signal transduction pathways. Full article
(This article belongs to the Special Issue Morphological Development of Candida)
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