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Special Issue "Fungal Infections of Implantation (Subcutaneous Mycoses)"

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A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 8956

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Special Issue Editors

Dr. Flavio Queiroz-Telles

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Guest Editor

1. Department of Public Health, Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil
2. Serviço de Infectologia, Hospital de Clinicas da Universidade Federal do Paraná, Rua General Carneiro, 260, Curitiba, Paraná 80060-900, Brazil
Interests: endemic mycoses; mycoses of implantation; paracoccidioidomycosis; cryptococcois; inherited immunodeficiencies and mycoses
Special Issues, Collections and Topics in MDPI journals

Dr. Daniel Wagner Santos

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Guest Editor

1. Hospital Universitário da Universidade Federal do Maranhão (HU-UFMA/Ebserh/MEC), Maranhão, Brazil
2. Instituto D'or de Pesquisa e Ensino, IDOR. Hospital UDI, Rede D’or, Maranhão, Brazil
Interests: chromoblastomycosis; phaeohyphomycosis; mycetoma; mycoses of implantation; Fungal Infections of Implantation (Subcutaneous Mycoses)

Special Issue Information

Dear Colleagues,

Implantation or inoculation mycoses are a heterogeneous group of fungal diseases with subacute to chronic manifestations starting at the site of the inoculation of pathogenic fungi that gain entrance into the body, through several types of transepithelial traumas. They are also known as “subcutaneous mycoses,” but this term seems to be imprecise as some of the implantation mycoses may also involve sites beyond the skin and the subcutaneous tissues (e.g., muscle, fascia, cartilage, bone). In the immunocompromised host, some implantation mycoses may spread from a cutaneous port of entry to internal organs and disseminate.

Implantation mycoses are distributed worldwide, causing endemic mycoses in tropical and subtropical zones like sporotrichosis, eumycetoma, chromoblastomycosis, lobomycosis, and entomophthoromycosis, as well asglobal fungal infections like fungal keratitis, phaeohyphomycosis, mucormycosis, scedosporiosis, fusariosis, etc.

Implantation fungal infections may be the cause of significant mobility and mortality rates in immunocompromised and immunocompetent hosts worldwide. Several implantation mycoses are also of veterinary interest, affecting different animals around the world, from cats to fish.

This Special Issue of Journal of Fungi will publish peer-reviewed manuscripts related to implantation mycoses of human and veterinary relevance.

Dr. Flavio Queiroz-Telles
Dr. Daniel Wagner Santos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (5 papers)

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Research

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Open AccessArticle

Invasive Rhinosinusitis Caused by Alternaria infectoria in a Patient with Autosomal Recessive CARD9 Deficiency and a Review of the Literature

Arnault Tauziède-Espariat

Jean-Laurent Casanova

Anne Puel

and

Fanny Lanternier

J. Fungi 2022, 8(5), 446; https://doi.org/10.3390/jof8050446 - 25 Apr 2022

Cited by 1 | Viewed by 1811

Abstract

Phaeohyphomycoses comprise a heterogeneous group of fungal infections caused by dematiaceous fungi and have primarily been reported in patients with underlying acquired immunodeficiencies, such as hematological malignancies or solid-organ transplants. Over the past decade, a growing number of patients with phaeohyphomycosis but otherwise healthy were reported with autosomal recessive (AR) CARD9 deficiency. We report a 28-year-old woman who presented with invasive rhinosinusitis caused by Alternaria infectoria. Following a candidate gene sequencing approach, we identified a biallelic loss-of-function mutation of CARD9, thereby further broadening the spectrum of invasive fungal diseases found in patients with inherited CARD9 deficiency. In addition, we reviewed 17 other cases of phaeohyphomycosis associated with AR CARD9 deficiency. Physicians should maintain a high degree of suspicion for inborn errors of immunity, namely CARD9 deficiency, when caring for previously healthy patients with phaeohyphomycosis, regardless of age at first presentation. Full article

(This article belongs to the Special Issue Fungal Infections of Implantation (Subcutaneous Mycoses))

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Open AccessArticle

Fungal Infections of Implantation: More Than Five Years of Cases of Subcutaneous Fungal Infections Seen at the UK Mycology Reference Laboratory

Andrew M. Borman

Mark Fraser

Zoe Patterson

Christopher J. Linton

Michael Palmer

and

Elizabeth M. Johnson

J. Fungi 2022, 8(4), 343; https://doi.org/10.3390/jof8040343 - 25 Mar 2022

Cited by 5 | Viewed by 1824

Abstract

Subcutaneous fungal infections, which typically result from traumatic introduction (implantation) of fungal elements into the skin or underlying tissues, can present as a range of different clinical entities including phaeohyphomycosis, chromoblastomycosis, subcutaneous nodules or masses, and genuine eumycetoma. Here, we mined our laboratory information management system for such infections in humans and domestic animals for the period 2016–2022, including (i) fungal isolates referred for identification and/or susceptibility testing; (ii) infections diagnosed at our laboratory using panfungal PCR approaches on infected tissue; and (iii) organisms cultured in our laboratory from biopsies. In total, 106 cases were retrieved, involving 39 fungal species comprising 26 distinct genera. Subcutaneous infections with Alternaria species were the most frequent (36 cases), which possibly reflects the ubiquitous nature of this common plant pathogen. A substantial proportion of Alternaria spp. isolates exhibited reduced in vitro susceptibility to voriconazole. Notably, a significant number of subcutaneous infections were diagnosed in renal and other solid organ transplant recipients post transplantation, suggesting that humans may harbour “inert” subcutaneous fungal elements from historical minor injuries that present as clinical infections upon later immunosuppression. The current study underscores the diversity of fungi that can cause subcutaneous infections. While most organisms catalogued here were responsible for occasional infections, several genera (Alternaria, Exophiala, Phaeoacremonuim, Scedosporium) were more frequently recovered in our searches, suggesting that they possess virulence factors that facilitate subcutaneous infections and/or inhabit natural niches that make them more likely to be traumatically inoculated. Full article

(This article belongs to the Special Issue Fungal Infections of Implantation (Subcutaneous Mycoses))

Open AccessArticle

Clinical and Epidemiological Characteristics of Sporotrichosis in a Reference Center of Uruguay

and

J. Fungi 2022, 8(3), 322; https://doi.org/10.3390/jof8030322 - 21 Mar 2022

Cited by 1 | Viewed by 1598

Abstract

Background: Sporotrichosis is a fungal implantation disease of subacute/ chronic course caused by species of the dimorphic fungus Sporothrix spp. This infection usually develops after traumatic inoculation of contaminated soil, plants or organic material contaminated by Sporothrix spp. conidia into skin or mucosa. The objective of this work is to contribute to the knowledge of sporotrichosis in Uruguay by providing a report of a series of cases diagnosed in a reference center. Methods: We conducted a retrospective, observational, descriptive and cross-sectional study of cases of sporotrichosis diagnosed in the last 38 years. Results: In the period analyzed, 157 cases of sporotrichosis were diagnosed, 152 of those corresponded to male patients. The most frequent clinical presentation was nodular lymphatic in 120 patients. In relation to epidemiological antecedents, 128 patients had been scratched by armadillos during hunting. Conclusions: Sporotrichosis in Uruguay is a sporadic disease with a clear seasonal pattern related to particular social practices, such as hunting armadillos. Related to this practice, the affectation is greater in males and in young adults. Full article

(This article belongs to the Special Issue Fungal Infections of Implantation (Subcutaneous Mycoses))

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Review

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Open AccessReview

Molecular Diagnosis of Two Major Implantation Mycoses: Chromoblastomycosis and Sporotrichosis

Danièle Maubon

Cécile Garnaud

Lala Soavina Ramarozatovo

Rapelanoro Rabenja Fahafahantsoa

Muriel Cornet

and

Tahinamandranto Rasamoelina

J. Fungi 2022, 8(4), 382; https://doi.org/10.3390/jof8040382 - 09 Apr 2022

Viewed by 1493

Abstract

Chromoblastomycosis and sporotrichosis are the two main implantation mycoses that are now recognized as fungal neglected tropical diseases (NTDs). Their laboratory diagnosis mainly relies on direct microscopy, histopathology, and identification of the fungus by culture. However, to be appropriately used, these techniques require mycological expertise that is not widely available and may be absent in peripheral health care facilities in endemic areas. In addition, they lack sensitivity and specificity, and the culture for isolation and identification can have a long time-to-results period. Molecular methods, including matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), have been developed in well-equipped reference laboratories. They greatly improve the rapidity and accuracy of diagnosis; in particular, for species identification. Recently, PCR and sequencing have paved the way for more user-friendly point-of-care tests, such as those based on LAMP or RCA technologies, which can be used in basic healthcare settings and even in field consultations. Full article

(This article belongs to the Special Issue Fungal Infections of Implantation (Subcutaneous Mycoses))

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Open AccessCase Report

An Atypical Etiology of Fungal Keratitis Caused by Roussoella neopustulans

Morgana F. Voidaleski

Flavio Queiroz-Telles

Regielly C. R. Cognialli

Roberta C. L. Crispim

and

Vania A. Vicente

J. Fungi 2022, 8(5), 507; https://doi.org/10.3390/jof8050507 - 15 May 2022

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Abstract

Fungal keratitis is caused by a wide spectrum of fungal genera, including molds and yeasts. We report a 42-year-old patient with mycotic keratitis after a direct trauma by a wood fragment. The fungal isolate was identified as Roussoella neopustulans by molecular methods. The treatment with topic natamycin showed progressive improvement of the visual manifestations, and following three months of therapy, the patient regained sight. We report the first case of keratitis associated with R. neopustulans. Full article

(This article belongs to the Special Issue Fungal Infections of Implantation (Subcutaneous Mycoses))

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Special Issue "Fungal Infections of Implantation (Subcutaneous Mycoses)"

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