Leveraging Yeast Genetics to Model Evolutionarily Conserved Aspects of Human Disease
A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 3337
Special Issue Editor
Interests: yeast genetics; cystic fibrosis; aging; cellular quiescence; cancer; phenomic models of disease
Special Issue Information
Dear Colleagues,
Yeast genetics has led the way for biological exploration to ultimately understand many aspects of human disease. Examples include fundamental roles of the central dogma, the cell cycle, protein trafficking, mitochondrial function, epigenetics, and other processes underlying disease. The power of yeast as a genetic model derives primarily from its relatively simple, unicellular eukaryotic nature and several unique organismal characteristics, rendering it especially amenable to genetic analysis. Despite remarkable contributions to understanding the biology of human diseases, yeast continues to harbor potential that is relatively untapped for this purpose. For example, the evidence for genetic complexity underlying human biology and disease continues to increase, as does the utility of yeast genetics to address it. This Special Issue has a purposefully broad scope to help to accomplish the objective of illuminating the complex genetics of cellular processes contributing to human disease and how analyses in yeast can be leveraged to address it through integrative biology. We invite all colleagues with passion for this topic to summarize, demonstrate, and/or propose how yeast genetic analysis, including phenomic modeling, complements studies in human or other models to inform our understanding of disease and thus discover and advance genetic-based therapeutic strategies.
Dr. John L Hartman IV
Guest Editor
Manuscript Submission Information
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Keywords
- yeast genetics
- human disease
- S. cerevisiae
- S. pombe
- phenomic modeling
- integrative biology