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Yeast Cytokinesis
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Yeast Cytokinesis

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3603

Special Issue Editors

Prof. Dr. Jian-Qiu Wu

E-Mail Website
Guest Editor
Department of Molecular Genetics, Ohio State University, Columbus, OH, USA
Interests: cytokinesis; cell division; cell biology; fission yeast; fungal genetics; cell integrity; anti-fungal drug targets
Prof. Dr. Erfei Bi

E-Mail Website
Guest Editor
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Interests: cytokinesis; abscission; actomyosin ring; exocytosis; ECM remodeling; septin; hepatocyte polarization; apical tube formation

Special Issue Information

Dear Colleagues,

Cytokinesis partitions cellular constituents from a mother cell into two daughter cells and plays essential roles in cell proliferation, cell differentiation, and tissue homeostasis. Due to powerful genetics, simple genomes, and efficient homologous recombination, both fission yeast and budding yeast have served as premier models for studying the general principles of cytokinesis with unrivaled spatial and temporal resolution. Cytokinesis in yeast can be divided into several critical stages: division site selection, actomyosin contractile ring assembly and constriction, targeted exocytosis for plasma membrane deposition and extracellular matrix (ECM)/cell wall remodeling, and cell separation. These stages are coordinated by conserved signaling pathways, namely the septation initiation network (SIN) in fission yeast and the mitotic exit network (MEN) in budding yeast. Tremendous progress has been made on all aspects of yeast cytokinesis in recent decades. In this Special Issue, we showcase a rich collection of both reviews and original research papers to reflect this progress, while focusing on the discoveries made over the last few years.

Prof. Dr. Jian-Qiu Wu
Prof. Dr. Erfei Bi 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell division
  • cytokinesis
  • contractile ring
  • septum formation
  • budding yeast
  • fission yeast
  • fungal genetics
  • microscopy
  • cell biology

Published Papers (3 papers)

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Review

12 pages, 1784 KiB  
Review
Processes Controlling the Contractile Ring during Cytokinesis in Fission Yeast, Including the Role of ESCRT Proteins
by Imane M. Rezig, Wandiahyel G. Yaduma and Christopher J. McInerny
J. Fungi 2024, 10(2), 154; https://doi.org/10.3390/jof10020154 - 15 Feb 2024
Viewed by 971
Abstract
Cytokinesis, as the last stage of the cell division cycle, is a tightly controlled process amongst all eukaryotes, with defective division leading to severe cellular consequences and implicated in serious human diseases and conditions such as cancer. Both mammalian cells and the fission [...] Read more.
Cytokinesis, as the last stage of the cell division cycle, is a tightly controlled process amongst all eukaryotes, with defective division leading to severe cellular consequences and implicated in serious human diseases and conditions such as cancer. Both mammalian cells and the fission yeast Schizosaccharomyces pombe use binary fission to divide into two equally sized daughter cells. Similar to mammalian cells, in S. pombe, cytokinetic division is driven by the assembly of an actomyosin contractile ring (ACR) at the cell equator between the two cell tips. The ACR is composed of a complex network of membrane scaffold proteins, actin filaments, myosin motors and other cytokinesis regulators. The contraction of the ACR leads to the formation of a cleavage furrow which is severed by the endosomal sorting complex required for transport (ESCRT) proteins, leading to the final cell separation during the last stage of cytokinesis, the abscission. This review describes recent findings defining the two phases of cytokinesis in S. pombe: ACR assembly and constriction, and their coordination with septation. In summary, we provide an overview of the current understanding of the mechanisms regulating ACR-mediated cytokinesis in S. pombe and emphasize a potential role of ESCRT proteins in this process. Full article
(This article belongs to the Special Issue Yeast Cytokinesis)
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19 pages, 2217 KiB  
Review
Meiotic Cytokinesis in Saccharomyces cerevisiae: Spores That Just Need Closure
by Matthew Durant, Xheni Mucelli and Linda S. Huang
J. Fungi 2024, 10(2), 132; https://doi.org/10.3390/jof10020132 - 06 Feb 2024
Viewed by 1107
Abstract
In the budding yeast Saccharomyces cerevisiae, sporulation occurs during starvation of a diploid cell and results in the formation of four haploid spores forming within the mother cell ascus. Meiosis divides the genetic material that is encapsulated by the prospore membrane that [...] Read more.
In the budding yeast Saccharomyces cerevisiae, sporulation occurs during starvation of a diploid cell and results in the formation of four haploid spores forming within the mother cell ascus. Meiosis divides the genetic material that is encapsulated by the prospore membrane that grows to surround the haploid nuclei; this membrane will eventually become the plasma membrane of the haploid spore. Cellularization of the spores occurs when the prospore membrane closes to capture the haploid nucleus along with some cytoplasmic material from the mother cell, and thus, closure of the prospore membrane is the meiotic cytokinetic event. This cytokinetic event involves the removal of the leading-edge protein complex, a complex of proteins that localizes to the leading edge of the growing prospore membrane. The development and closure of the prospore membrane must be coordinated with other meiotic exit events such as spindle disassembly. Timing of the closure of the prospore membrane depends on the meiotic exit pathway, which utilizes Cdc15, a Hippo-like kinase, and Sps1, an STE20 family GCKIII kinase, acting in parallel to the E3 ligase Ama1-APC/C. This review describes the sporulation process and focuses on the development of the prospore membrane and the regulation of prospore membrane closure. Full article
(This article belongs to the Special Issue Yeast Cytokinesis)
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14 pages, 1180 KiB  
Review
The Roles of Septins in Regulating Fission Yeast Cytokinesis
by Shengnan Zheng, Biyu Zheng and Chuanhai Fu
J. Fungi 2024, 10(2), 115; https://doi.org/10.3390/jof10020115 - 30 Jan 2024
Viewed by 909
Abstract
Cytokinesis is required to separate two daughter cells at the end of mitosis, and septins play crucial roles in many aspects of cytokinesis. While septins have been intensively studied in many model organisms, including the budding yeast Saccharomyces cerevisiae, septins have been [...] Read more.
Cytokinesis is required to separate two daughter cells at the end of mitosis, and septins play crucial roles in many aspects of cytokinesis. While septins have been intensively studied in many model organisms, including the budding yeast Saccharomyces cerevisiae, septins have been relatively less characterized in the fission yeast Schizosaccharomyces pombe, which has proven to be an excellent model organism for studying fundamental cell biology. In this review, we summarize the findings of septins made in fission yeasts mainly from four aspects: the domain structure of septins, the localization of septins during the cell cycle, the roles of septins in regulating cytokinesis, and the regulatory proteins of septins. Full article
(This article belongs to the Special Issue Yeast Cytokinesis)
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