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Biomaterials in Tissue, Biomedical and Surface Engineering
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Biomaterials in Tissue, Biomedical and Surface Engineering

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 5733

Special Issue Editors

Dr. Muhammad Wajid Ullah

E-Mail Website
Guest Editor
Biofuels Institute, Jiangsu University, Zhenjiang 212013, China
Interests: bacterial cellulose; bioprinting; 3D scaffolds; tissue engineering; drug delivery; biosensing; cell-free biosynthesis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Guang Yang

E-Mail Website
Guest Editor
School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: medical materials; drug carrier; photoelectric materials; ordered nanomaterial assembly
Special Issues, Collections and Topics in MDPI journals
Dr. Sehrish Manan

E-Mail Website
Guest Editor
School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: biomaterials; polysaccharides; genetic engineering; transformation; biofilms; metabolic engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few decades, advancements in materials science and engineering, materials chemistry and physics, and nanotechnology have demonstrated great capabilities in developing novel and advanced biomaterials with desired structural, functional, and biological properties. These biomaterials are synthesized by using polymeric materials from renewable resources such as microorganisms, insects, animals, and plants, as well as non-polymer materials such as nanomaterials. Some of these biomaterials possess interesting structural features such as hydrophilicity/hydrophobicity, high mechanical strength, stiffness, unique textures, optical transparency, biodegradability, non-toxicity, and biocompatibility, as well as antimicrobial, antiviral, antioxidant, anti-inflammatory, and anticancer activities. These materials are applied in the form of scaffolds, gels, sheets, films, membrane, pellets, filaments, fibres, tubes, capsules, sponges, and others for various biomedical applications such as tissue engineering, wound dressing, drug delivery, bioink for 3D printing, biosensors, and others. This Special Issue aims to present articles (research articles, mini- and full-length reviews, and communications) covering the fabrication techniques, functionalization, and biomedical applications of various biomaterials on, but not limited to:

  • The preparation and characterization of biomaterials;
  • Functionalization: chemical modification and composite synthesis;
  • Tuning the structural features (i.e., structure–function relationship);
  • The evaluation of biological properties (biocompatibility, biodegradability, immunogenicity, toxicity) and advanced assays;
  • Applications;
  • Skin tissue engineering;
  • Bone and cartilage tissues development;
  • Development of blood vessels and heart valves;
  • Neural tissue engineering;
  • Development of urinary conduits;
  • Tympanic membrane;
  • Ophthalmic tissues: lens and cornea;
  • Drug delivery;
  • Biosensing;
  • 3D/4D bioprinting;
  • Others

Dr. Muhammad Wajid Ullah
Prof. Dr. Guang Yang
Dr. Sehrish Manan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • microbial and non-microbial polymers
  • fabrication techniques
  • surface modification
  • functionalization
  • characterization
  • characterization
  • 3D printing
  • scaffolds
  • biocompatibility
  • tissue engineering
  • regenerative medicines
  • skin tissues
  • bone and cartilage tissues
  • cardiovascular tissues
  • ocular tissues

Published Papers (3 papers)

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Research

11 pages, 3716 KiB  
Article
Study of the Effect of Anodic Oxidation on the Corrosion Properties of the Ti6Al4V Implant Produced from SLM
by Ada Orłowska, Janusz Szewczenko, Wojciech Kajzer, Karolina Goldsztajn and Marcin Basiaga
J. Funct. Biomater. 2023, 14(4), 191; https://doi.org/10.3390/jfb14040191 - 29 Mar 2023
Cited by 4 | Viewed by 1182
Abstract
Additive technologies allowed for the development of medicine and implantology, enabling the production of personalized and highly porous implants. Although implants of this type are used clinically, they are usually only heat treated. Surface modification using electrochemical methods can significantly improve the biocompatibility [...] Read more.
Additive technologies allowed for the development of medicine and implantology, enabling the production of personalized and highly porous implants. Although implants of this type are used clinically, they are usually only heat treated. Surface modification using electrochemical methods can significantly improve the biocompatibility of biomaterials used for implants, including printed ones. The study examined the effect of anodizing oxidation on the biocompatibility of a porous implant made of Ti6Al4V by the SLM method. The study used a proprietary spinal implant intended for the treatment of discopathy in the c4–c5 section. As part of the work, the manufactured implant was assessed in terms of compliance with the requirements for implants (structure testing—metallography) and the accuracy of the pores produced (pore size and porosity). The samples were subjected to surface modification using anodic oxidation. The research was carried out for 6 weeks in in vitro conditions. Surface topographies and corrosion properties (corrosion potential, ion release) were compared for unmodified and anodically oxidized samples. The tests showed no effect of anodic oxidation on the surface topography and improved corrosion properties. Anodic oxidation stabilized the corrosion potential and limited the release of ions to the environment. Full article
(This article belongs to the Special Issue Biomaterials in Tissue, Biomedical and Surface Engineering)
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16 pages, 15764 KiB  
Article
Characteristics and Surface Serviceability for Cryogenic Milling Mg-1.6Ca-2.0Zn Medical Magnesium Alloy
by Xuan Guo, Guodong Liu, Shunheng Sang, Qichao Lin and Yang Qiao
J. Funct. Biomater. 2022, 13(4), 179; https://doi.org/10.3390/jfb13040179 - 07 Oct 2022
Cited by 2 | Viewed by 1121
Abstract
Magnesium alloy has great potential as a new medical metal material because of its good biocompatibility and biodegradability. However, because of the active chemical properties of magnesium alloy, it is easy to react with oxygen and cutting fluid to release hydrogen. In this [...] Read more.
Magnesium alloy has great potential as a new medical metal material because of its good biocompatibility and biodegradability. However, because of the active chemical properties of magnesium alloy, it is easy to react with oxygen and cutting fluid to release hydrogen. In this paper, by cutting magnesium alloys prepared under different cooling conditions, the phase composition of the machined surface was studied. Tensile strength and elongation were studied through tensile experiments at different temperatures. The effect of cryogenic milling on the service performance of a magnesium alloy machined surface was studied by the friction and wear test and electrochemical corrosion test. The results show that cryogenic milling contributes to the formation of the second phase of magnesium alloy, which has the effect of corrosion resistance, and has better tensile strength and elongation. Through the friction and wear test, it is found that the average friction coefficient decreases by about 7.4%, and the wear amount decreases by about 10% in the liquid nitrogen cooling environment. Through the electrochemical corrosion test, it was found that the oxide film formed in the liquid nitrogen cooling environment was more compact and uniform, and the crystal refinement of the surface layer was better. Full article
(This article belongs to the Special Issue Biomaterials in Tissue, Biomedical and Surface Engineering)
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18 pages, 6492 KiB  
Article
Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO2 Nanostructures Prepared by Atomic Layer Deposition
by Denis Nazarov, Ilya Ezhov, Natalia Yudintceva, Maxim Shevtsov, Aida Rudakova, Vladimir Kalganov, Vladimir Tolmachev, Yuliya Zharova, Oleksiy Lutakov, Ludmila Kraeva, Elizaveta Rogacheva and Maxim Maximov
J. Funct. Biomater. 2022, 13(2), 62; https://doi.org/10.3390/jfb13020062 - 18 May 2022
Cited by 17 | Viewed by 2755
Abstract
The combination of titania nanofilms and silver nanoparticles (NPs) is a very promising material, with antibacterial and osseointegration-induced properties for titanium implant coatings. In this work, we successfully prepared TiO2 nanolayer/Ag NP structures on titanium disks using atomic layer deposition (ALD). The [...] Read more.
The combination of titania nanofilms and silver nanoparticles (NPs) is a very promising material, with antibacterial and osseointegration-induced properties for titanium implant coatings. In this work, we successfully prepared TiO2 nanolayer/Ag NP structures on titanium disks using atomic layer deposition (ALD). The samples were studied by scanning electron microscopy (SEM), X-ray diffraction, X-ray photoelectron spectroscopy (XPS), contact angle measurements, and SEM-EDS. Antibacterial activity was tested against Staphylococcus aureus. The in vitro cytological response of MG-63 osteosarcoma and human fetal mesenchymal stem cells (FetMSCs) was examined using SEM study of their morphology, MTT test of viability and differentiation using alkaline phosphatase and osteopontin with and without medium-induced differentiation in the osteogenic direction. The samples with TiO2 nanolayers, Ag NPs, and a TiO2/Ag combination showed high antibacterial activity, differentiation in the osteogenic direction, and non-cytotoxicity. The medium for differentiation significantly improved osteogenic differentiation, but the ALD coatings also stimulated differentiation in the absence of the medium. The TiO2/Ag samples showed the best antibacterial ability and differentiation in the osteogenic direction, indicating the success of the combining of TiO2 and Ag to produce a multifunctional biocompatible and bactericidal material. Full article
(This article belongs to the Special Issue Biomaterials in Tissue, Biomedical and Surface Engineering)
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