Cell Tissue Engineering and the Lung

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (1 December 2022) | Viewed by 2918

Special Issue Editors

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Guest Editor
North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Interests: corneal wound healing; cornea trauma; keratoconus; bioengineering; bioprinting; diabetic keratopathy
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Guest Editor
Medical College of Wisconsin, Milwaukee, WI 53226, USA
Interests: lung transplantation; advanced lung disease; biomedical engineering; idiopathic pulmonary fibrosis; chronic lung allograft dysfunction; ex vivo lung perfusion

Special Issue Information

Dear Colleagues,

Cell tissue engineering approaches can be used to regenerate damaged organs or even replace dysfunctional ones. The lung is an organ that primarily functions to transport oxygen into the blood and remove carbon dioxide. Many lung diseases may initially limit patient functional activity and can ultimately lead to respiratory failure and death.  Current medications have limited efficacy for common disorders such as emphysema and pulmonary fibrosis. In the United States, approximately 2500 adults receive lung transplants each year. Due to limitations in donor availability and suboptimal outcomes, many more suffer the effects of lung disease or die without lung transplant. The one-year survival in the US is 86.7%, and the five-year survival is 52.5%.

Current developments in biomaterials and/or cell tissue engineering involve the use of cell culture on three-dimensional scaffolds, highlighting the importance of extracellular matrix composition and how it can modulate lung compliance and limit its ability to expand and ventilate effectively. Other technologies include the investigation of 3D printing technologies, hybrid biomaterials, biomechanical cues, mechanobiology, and tissue engineering—all necessary to achieve the ultimate goals of in vivo effectiveness.

We invite you to contribute your work to this Special Issue of JFB on “Cell tissue engineering and the lung”. We welcome full articles, short communications, or reviews to highlight all the recent findings that have broadened lung-related horizons, including, but not limited to, the availability of new bioprinting approaches; technological advancements of established techniques or processes; progress in cell and tissue engineering; the translation of technologies from bench to bedside; and achievements in the clinical and regulatory field.

Prof. Dr. Dimitrios Karamichos
Dr. Alan Betensley
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell tissue engineering
  • biomaterials
  • lung
  • bioprinting

Published Papers (1 paper)

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17 pages, 5826 KiB  
SpAD Biofunctionalized Cellulose Acetate Scaffolds Inhibit Staphylococcus aureus Adherence in a Coordinating Function with the von Willebrand A1 Domain (vWF A1)
by Stefanos Pendas, Antonis Asiminas, Alexandros Katranidis, Costas Tsioptsias, Maria Pitou, Georgios Papadopoulos and Theodora Choli-Papadopoulou
J. Funct. Biomater. 2022, 13(1), 21; https://doi.org/10.3390/jfb13010021 - 21 Feb 2022
Cited by 2 | Viewed by 2368
Staphylococcus aureus is one of the major pathogens causing and spreading hospital acquired infections. Since it is highly resistant to new generation antibiotics, novel strategies have to be developed such as the construction of biofunctionalized non-adherent surfaces that will prevent its tethering and [...] Read more.
Staphylococcus aureus is one of the major pathogens causing and spreading hospital acquired infections. Since it is highly resistant to new generation antibiotics, novel strategies have to be developed such as the construction of biofunctionalized non-adherent surfaces that will prevent its tethering and subsequent spread in the hospital environment. In this frame, the domain D of protein A (SpAD) of S. aureus has been immobilized onto cellulose acetate scaffolds by using the streptavidin/biotin interaction, in order to study its interaction with the A1 domain of von Willebrand factor (vWF A1), a protein essential for hemostasis, found in human plasma. Subsequently, the biofunctionalized cellulose acetate scaffolds were incubated with S. aureus in the presence and absence of vWF A1 at different time periods and their potential to inhibit S. aureus growth was studied with scanning electron microscopy (SEM). The SpAD biofunctionalized scaffolds perceptibly ameliorated the non-adherent properties of the material, and in particular, the interaction between SpAD and vWF A1 effectively inhibited the growth of S. aureus. Thus, the exhibition of significant non-adherent properties of scaffolds addresses their potential use for covering medical equipment, implants, and stents. Full article
(This article belongs to the Special Issue Cell Tissue Engineering and the Lung)
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