Bio-Abio Nanocomposites for Bio-Applications, Volume II

A special issue of Journal of Composites Science (ISSN 2504-477X). This special issue belongs to the section "Biocomposites".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4000

Special Issue Editors


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Guest Editor
Faculty of Cardiovascular Research Institute, Graduate Scool of Medicine, Yokohama City University, Yokohama, Japan
Interests: surface and colloid chemistry; synthesis of hybrid nanocomposites; nano-pharmaceutics/theranostics; drug delivery systems; smart nanocomposites; bio-inspired nanosheet composites
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Guest Editor
Nanomaterials Lab., College of Engineering, Swansea University, Swansea, UK
Interests: surface and interfaces; biomagnetic separation; hybrid nanomaterials; advanced characterization; spectroscopy; electron microscopy; nanostructures

Special Issue Information

Dear Colleagues,

The unseen exclusive properties of nanocomposites have fascinated researchers, especially in bio-applications due to their combined/synergistic structural features with diverse components derived from nature and synthetic systems. The key challenge is a controlled synthesis of interracially/spatially well-defined heterogeneous structures, biocompatible functionalization, and stable processing to be acceptable for translational/clinical stages. Thus, harmonizing the structure–property–processing of nanocomposites of divergent (bio-abio) materials is crucial for their future bio-applications as innovative hybrid material systems.

The scope of this Special Issue covers state-of-the-art synthesis and functions of heterogeneous nanocomposite materials to offer an insight into this new family of composites with the incorporation of dissimilar bio/abio-building blocks with interest in diverse bio-applications, including, in particular, pharmaceutics, biodiagnostics, therapeutics, bioimaging, or biosensing. Contributions should be primarily related to the orchestrated chemical design of biocompatible hybrid nanocomposite structures, such as particles, assemblies, dispersions, surface/interface; their unique properties by mixing/coupling their components, e.g., biomolecules, polymers, biodegradable materials, green/natural products, and biosafe inorganic minerals/materials; and the functionalization of bio-nano-interfaces.

Prof. Dr. Jeong-Hwan Kim
Dr. Maria Benelmekki
Guest Editors

Manuscript Submission Information

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Keywords

  • nanocomposites
  • nanoparticles
  • heterogeneous materials interface
  • surface functionalization
  • aqueous dispersion
  • material properties
  • biodiagnostics/therapeutics

Published Papers (2 papers)

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Research

15 pages, 6416 KiB  
Article
Synergistic Action between Copper Oxide (CuO) Nanoparticles and Anthraquinone-2-Carboxylic Acid (AQ) against Staphylococcus aureus
by Prakhar Srivastava, Yongjun Kim, Hyejin Cho and Kwang-sun Kim
J. Compos. Sci. 2023, 7(4), 135; https://doi.org/10.3390/jcs7040135 - 03 Apr 2023
Cited by 2 | Viewed by 1751
Abstract
Infections linked to Staphylococcus spp. are difficult to treat with current antibiotic therapy, resulting in increased antibiotic resistance populations. One of the leading strategies to overcome this issue is the novel combination of antibacterial nanoparticles (NPs) and sustainable natural compounds. This study reported [...] Read more.
Infections linked to Staphylococcus spp. are difficult to treat with current antibiotic therapy, resulting in increased antibiotic resistance populations. One of the leading strategies to overcome this issue is the novel combination of antibacterial nanoparticles (NPs) and sustainable natural compounds. This study reported the identification of a new synergistic combination of copper oxide (CuO) NPs, a well-known antibacterial agent against Staphylococcus spp., and anthraquinone-2-carboxylic acid (AQ), a plant-derived antimicrobial compound, with a potent and specific fashion in killing Staphylococcus spp. CuO NPs were synthesized using the one-pot coprecipitation method and characterized by using X-ray diffraction and transmission electron microscopy. Further checkerboard analysis showed that CuO NPs and AQ increased the antibacterial activity of individual agents against Staphylococcus aureus among Staphylococcus spp. by four- to eightfold compared to individual materials. Additional mechanistic studies on the synergy revealed that the inhibition of biofilm formation and loss of cytoplasmic volume with cell shrinkage are the major actions of the combination in expressing the phenotype. This study clearly showed that the combination of CuO NPs and AQ would be a novel strategy to eradicate S. aureus infections. Full article
(This article belongs to the Special Issue Bio-Abio Nanocomposites for Bio-Applications, Volume II)
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17 pages, 3317 KiB  
Article
Nanocomposites of Terbium Sulfide Nanoparticles with a Chitosan Capping Agent for Antibacterial Applications
by Eny Kusrini, Alya Irma Safira, Anwar Usman, Eko Adi Prasetyanto, Khoirina Dwi Nugrahaningtyas, Sri Juari Santosa and Lee D. Wilson
J. Compos. Sci. 2023, 7(1), 39; https://doi.org/10.3390/jcs7010039 - 12 Jan 2023
Cited by 4 | Viewed by 1839
Abstract
This study aims to investigate the effect of alkaline pH on the bottom-up synthesis of nanocomposites (NCs) containing terbium sulfide nanoparticles (Tb2S3 NPs), where chitosan (CS) was employed as a capping agent, along with evaluation of the antibacterial activity of [...] Read more.
This study aims to investigate the effect of alkaline pH on the bottom-up synthesis of nanocomposites (NCs) containing terbium sulfide nanoparticles (Tb2S3 NPs), where chitosan (CS) was employed as a capping agent, along with evaluation of the antibacterial activity of these NCs. The NCs were characterized using spectroscopy (FESEM-EDX, Raman, FTIR, XRD, XPS, and DLS), zeta-potential, and TGA. The results of FE-SEM, XPS, Raman, and FTIR characterization support the formation of CS-Tb2S3 NPs. A pH variation from 9 to 11 during composite formation was shown to affect the size and composition of NCs. The antibacterial activity of CS-Tb2S3 NCs was studied by coating onto commercial contact lenses, where the best loading efficiency of NCs was 48%. The NCs prepared at pH 10 (without contact lenses) had greater antibacterial activity against Staphylococcus aureus, with a zone of inhibition diameter of 7.15 mm. The coating of NCs onto commercial contact lenses was less effective for inhibition of Staphylococcus aureus, in contrast with the greater activity observed for tetracycline. CS-Tb2S3 NCs offer promising antimicrobial properties that can be further optimized by control of the surface loading and accessibility of Tb2S3 NPs through further study of the role of the chitosan capping agent, since steric effects due to CS are likely to attenuate antimicrobial activity via reduced electron transfer in such nanocomposite systems. Full article
(This article belongs to the Special Issue Bio-Abio Nanocomposites for Bio-Applications, Volume II)
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