Amyotrophic Lateral Sclerosis: Latest Advances and Prospects
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 18850
2. UKM Marienhospital Steinfurt, Department of Medicine, Mauritiusstr. 5, 48565 Steinfurt, Germany
Interests: sleep; non-invasive ventilation
Interests: disease modelling using hiPSCs; pathophysiology of ALS (DNA damage, mitochondria, mitochondria–ER interactions); modelling ageing in neurodegenerative diseases; patient-centered care using eye-tracking computer systems
Special Issues, Collections and Topics in MDPI journals
Amyotrophic lateral sclerosis (ALS) is still a devastating disease associated with motor neuron degeneration, progressive muscle weakness, and premature death. Although knowledge has markedly increased with regard to underlying pathomechanisms, molecular genetics of ALS, disease biomarkers, and clinical subtype stratification, no effective treatment is currently available, and medical therapy is restricted to disease deceleration, alleviation of symptoms, and palliative care. However, several advances have recently been made and may foster meaningful improvement of both symptomatic and causative treatment strategies. This Topical Collection is intended to cover a broad spectrum of related topics, including the molecular pathology and genetics of motor neuron degeneration, biomarkers and models of disease progression, and a comprehensive approach to patient-centered care from disease onset to the point of palliation. In the latter context, adequate treatment of respiratory muscle weakness and nutritional support are of utmost importance and will be specifically addressed. This Special Issue will present original research work as well as scientific reviews, aiming to address neurologists, with a special focus on ALS but also on physicians and researchers generally interested in neurodegeneration, respiratory care, and palliative medicine.
Dr. Matthias Boentert
Prof. Dr. Andreas Hermann
Dr. Julian Grosskreutz
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- amyotrophic lateral sclerosis
- disease progression modelling
- biomarkers in motor neuron disease
- respiratory muscle weakness
- neuropalliative care
- treatment strategies for motor neuron disease