Chiari 1 Malformation, Syringomyelia and Related Disorders: Advances in Diagnosis and Treatment for Adults and Children
Deadline for manuscript submissions: 31 March 2024 | Viewed by 38178
Chiari 1 Malformation (CM1) is classically defined as a caudal displacement of the cerebellar tonsils through the foramen magnum into the spinal cord, but modern imaging techniques and experimental studies disclose a different aetiology. Other disorders, such as syringomyelia, hydrocephalus, craniocervical instability can be associated at the time of the diagnosis or appear secondarily. Syringomyelia (Syr) is morphologically defined at magnetic resonance imaging (MRI) as the presence of a single or multiple fluid-filled cavities within the spinal cord and/or the bulb (Syringobulbia) and classified as a neurological rare disease (ORPHA3280). CM1 is classified as a rare disease (ORPHA268882), but epidemiology has been scarcely investigated. When CM1 is defined by cerebellar tonsil position 5 mm or more below the foramen magnum, MRI prevalence studies estimate prevalence at between 0.24 and 3.6% of the population; the discrepancy between these estimates is a result of the different age groups analysed, as the prevalence is substantially higher in children and young adults compared with older adults. Chiari can present with a wide variety of symptoms, also non-specific, with consequent controversies on diagnosis and surgical decision-making. The potential anatomy changes during maturation influence the decision to treat a younger versus an older patient with Chiari, particularly in asymptomatic o minimally symptomatic.
In this background, the aim of this Special Issue of Journal of Clinical Medicine is to attract high-quality studies covering pathogenesis, diagnosis and management of Chiari and Syringomyelia.
Contributors are encouraged to submit articles describing novel results, models, methodological innovations or reviews. We will strive to ensure that the articles of the Special Issue collectively present a cohesive picture of the state-of-the-art in the field and help to advance our understanding and management of these conditions.
The topics we wish to cover include but are not limited to:
- Epidemiology of Chiari Malformation, syringomyelia and related disorders
- Pathophysiology of Chiari: Hydrodynamics of Cerebro-Spinal Fluid flow
- Pathogenesis of Syringomyelia: lessons from observations in dogs
- The role of genetics in Chiari Malformation and Syringomyelia
- Clinical phenotypes in Chiari and in Syringomeylia
- Diagnostic investigations: old and new neurophysiological methods
- Neuroradiological definitions of Chiari Malformation, Syringomyelia and related disorders
- Advances in neuroradiological techniques in the diagnosis of Chiari Malformations and Syringomyelia
- Surgery in Chiari 1 Malformation with and without Syringomyelia
- Surgical strategies in isolated Syringomyelia
- Outcome measures in Chiari and Syringomyelia long-term follow up
Dr. Palma Ciaramitaro
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- chiari maformation
- epidemiology genetics
- cerebro-spinal fluid
- outcome measures
- clinical outcome