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Making and Management of Breast Reconstruction: From Theory to Clinical...
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Making and Management of Breast Reconstruction: From Theory to Clinical Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine".

Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 10848

Special Issue Editor

Prof. Dr. Roberto Cuomo

E-Mail Website
Guest Editor
UNISI, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
Interests: Plastic surgery; regeneration; wound healing; skin cancer; breast reconstruction; cosmetic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Breast cancer surgery and breast reconstruction are probably among the most discussed (and sometimes controversial) topics of the past two centuries.

Cancer surgery and reconstruction procedures have been evolved in time and now are often thought as one in the same.

A correct planning takes a crucial role: to plan an excellent demolition to ensure satisfactory reconstruction (as well as local cancer treatment).

The main purpose (and the main difficulty) of breast reconstruction is to restore shape, volume and symmetry of both the breast and the nipple areola complex. This is achieved by the use of autologous tissues (pedunculated/microsurgical flaps), by techniques of regenerative surgery and by the use of biological and prosthetic devices. A lot of techniques have been described to obtain good results and many researchers are focused also on medical procedures to increase outcomes. Clarity is needed on this topic based on scientific evidences.

Moreover, some kind of prosthesys have been largely criticised recently after the finding of “Breast Implant-associated Anaplastic Large Cell Lymphoma”.

This Special Issue of Journal of clinical medicine entitled “Making and Management of Breast Reconstruction: from Theory to Clinical Practice” welcomes the submission of basic or clinical original articles, as well as systematic reviews, meta-analyses, and overviews, that discuss limits and points of strenght of techniques for breast reconstruction as well as innovations and evolutions in this field.

Prof. Dr. Roberto Cuomo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Breast reconstruction
  • Prosthesis
  • Flap
  • Microsurgery
  • BIA-ALCL

Published Papers (4 papers)

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Research

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15 pages, 4174 KiB  
Article
Positive ROS (Reactive Oxygen Species) Modulator Engineered Device Support Skin Treatment in Locally Advanced Breast Cancer (LABC) Enhancing Patient Quality of Life
by Donato Casella, Paolo Palumbo, Sara Sandroni, Claudio Caponi, Francesca Littori, Francesca Capuano, Luca Grimaldi, Marco Marcasciano and Roberto Cuomo
J. Clin. Med. 2022, 11(1), 126; https://doi.org/10.3390/jcm11010126 - 27 Dec 2021
Cited by 10 | Viewed by 4508
Abstract
The development of research in genetic and biochemical fields has made it possible to investigate certain metabolic aspects of the microenvironment of chronic skin lesions, including altered cell signalling, highlighting its importance in determining the blockage of repair processes. The purpose of this [...] Read more.
The development of research in genetic and biochemical fields has made it possible to investigate certain metabolic aspects of the microenvironment of chronic skin lesions, including altered cell signalling, highlighting its importance in determining the blockage of repair processes. The purpose of this prospective observational study is to evaluate the efficacy of a medical device consisting of a polyester scaffold enriched with an oleic matrix with controlled release of ROS in the management of LABC skin lesions. During the period from October 2018 to March 2020, 20 patients with locally advanced breast cancer were enrolled and ten were treated with the devices abovementioned. After 30 days of treatment all patients treated reported a general improvement in local conditions with reduction in ulceration area, exudate and odour. The results suggest that the application of these devices even in particular conditions (healthy and neoplastic tissue) does not lead to the onset of negative effects due to the release of ROS, though their role in tissue repair requires further study to fully understand their potential and increase the fields of application of the device by exploiting its modulation capabilities. Full article
(This article belongs to the Special Issue Making and Management of Breast Reconstruction: From Theory to Clinical Practice)
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11 pages, 840 KiB  
Article
A Prospective Investigation of Predictive Parameters for Preoperative Volume Assessment in Breast Reconstruction
by Nicola Zingaretti, Giovanni Miotti, Carlo Alberto Maronese, Miriam Isola, Gianni Franco Guarneri, Roberta Albanese, Francesco De Francesco, Michele Riccio, Lorenzo Cereser, Chiara Zuiani and Pier Camillo Parodi
J. Clin. Med. 2021, 10(22), 5216; https://doi.org/10.3390/jcm10225216 - 09 Nov 2021
Cited by 3 | Viewed by 1395
Abstract
Preoperative breast volume estimation is very important for the success of the breast surgery. In this study four different breast volume determination methods were compared. The end-point of this prospective study was to evaluate the concordance between different modalities of breast volume assessment [...] Read more.
Preoperative breast volume estimation is very important for the success of the breast surgery. In this study four different breast volume determination methods were compared. The end-point of this prospective study was to evaluate the concordance between different modalities of breast volume assessment (MRI, BREAST-V, mastectomy specimen weight, conversion from weight to volume of mastectomy specimen) and the breast prosthetic volume implanted. The study enrolled 64 patients between 2017 and 2019, who had all been treated by the same surgeons for monolateral nipple–areola complex-sparing mastectomy and implant breast reconstruction. Only patients who had a breast reconstruction classified as “excellent” from an objective (BCCT.core software) and subjective (questionnaire) point of view at the 6-month interval after the operation were included in the study. Data analysis highlighted a strong correlation between the volumes of the chosen prostheses and the weights of mastectomy converted into volume, especially for patients with grades B and C parenchymal density. The values of the agreement between the volumes of the chosen prostheses and the assessments from MRI and BREAST -V proved to be lower than expected from the literature. None of the four studied methods presented any strong correlation with the initial breast width. Our results suggest that conversion from weight to volume of mastectomy specimen should be used to assist in determining the volume of the breast implant to be implanted. This method would help the reconstructive surgeon guide the choice of the most appropriate implant preoperatively. Full article
(This article belongs to the Special Issue Making and Management of Breast Reconstruction: From Theory to Clinical Practice)
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Review

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8 pages, 220 KiB  
Review
The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review
by Roberto Cuomo
J. Clin. Med. 2021, 10(10), 2082; https://doi.org/10.3390/jcm10102082 - 12 May 2021
Cited by 21 | Viewed by 2155
Abstract
Background: Breast-implant-associated anaplastic large cell lymphoma is a rare malignancy linked to texturized breast implants. Although many researchers focus on its etiopathogenesis, this topic is affected by a lack of evidence. Materials and Methods: A literature review about BIA-ALCL was made. Results and [...] Read more.
Background: Breast-implant-associated anaplastic large cell lymphoma is a rare malignancy linked to texturized breast implants. Although many researchers focus on its etiopathogenesis, this topic is affected by a lack of evidence. Materials and Methods: A literature review about BIA-ALCL was made. Results and conclusions: Although the incidence is reported between 1:355–1:30,000, there is great attention to BIA-ALCL. The incidence is uncertain due to many reasons. It may well be lower, due to inclusion in multiple databases as pointed out by the FDA and undiagnosed cases. The role of chronic inflammation, bacterial contamination, and mechanical forces was discussed. Clarification is needed to understand the mechanisms underlying the progression of alterations and mutations for BIA-ALCL; new molecular analysis and pathogenetic models should be investigated. Full article
(This article belongs to the Special Issue Making and Management of Breast Reconstruction: From Theory to Clinical Practice)

Other

Jump to: Research, Review

12 pages, 2585 KiB  
Technical Note
The Partial Removal of Rectus Abdominis Muscle Inserting into Ribs in Ipsilateral Pedicled TRAM Flap for Breast Reconstruction
by Daegu Son and Jaehoon Kim
J. Clin. Med. 2022, 11(22), 6647; https://doi.org/10.3390/jcm11226647 - 09 Nov 2022
Viewed by 1834
Abstract
Background: The purpose of this study was to introduce a new surgical technique for pedicled TRAM flap that removes a part of the rectus abdominis muscle inserting into ribs, and to analyze this technique in comparison with classical pedicled TRAM flap. Methods: A [...] Read more.
Background: The purpose of this study was to introduce a new surgical technique for pedicled TRAM flap that removes a part of the rectus abdominis muscle inserting into ribs, and to analyze this technique in comparison with classical pedicled TRAM flap. Methods: A retrospective review of patient charts from May 2006 to February 2016 was performed. The patient group that underwent the removal of the part of the rectus abdominis that inserts into the thorax (partial muscle resection; PMR group) was compared with the group that did not undergo this muscle resection (Classical group). The complications and aesthetic effects of surgery between the two groups were analyzed. Results: There were 34 patients in the classical group and 28 in the PMR group. There were no significant differences in postoperative complications between these two groups. The rates of fat necrosis were 32.1% in the PMR group and 36.1% in the classical group. The postoperative aesthetic outcome of the inframammary fold showed no significant differences in outcome between the classical and PMR groups. However, all items received higher scores in the PMR group. Conclusions: The authors’ new surgical method was associated with a positive cosmetic effect of improving inframammary fold aesthetics and could thus represent a new option for pTRAM breast reconstruction. Full article
(This article belongs to the Special Issue Making and Management of Breast Reconstruction: From Theory to Clinical Practice)
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