Special Issue "Clinical Updates on Graves' Disease"
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 243
Interests: thyroid autoimmunity; Graves' disease; Hashimoto's thyroiditis; Graves' orbitopathy; thyroid cancer; pituitary gland; iodine
Interests: thyroid autoimmunity; Graves' disease; Hashimoto's thyroiditis; Vitamina D; Selenium; obesity
Special Issues, Collections and Topics in MDPI journals
Graves’ disease (GD) is a common autoimmune disorder in which antibodies stimulating the thyrotropin receptors (TSHR-Ab) cause hyperthyroidism and goiter. The most relevant extrathyroid manifestation is Graves’ orbitopathy (GO), which is severe in almost 5% of cases and potentially sight-threatening. In most cases, anti-thyroid drug treatment represents the primary therapeutic approach but carries a high risk of hyperthyroidism relapse after discontinuation. Alternative treatments are radioiodine and thyroidectomy, which invariably determine hypothyroidism. Glucocorticoids represent a milestone but imperfect treatment for GO. Thus, a crucial topic of research is the improvement of GD and GO management. Strategies might include the early identification of those patients at higher risk of refractory hyperthyroidism or relapse that would benefit from a definitive approach. Importantly, novel discoveries in the pathogenesis of GD and GO paved the way for new therapies, targeting TSHR-Ab, IGF-1R, or modulating the immune response. We invite investigators working in this field of research to submit original research articles or reviews on the most recent advancements in this topic.
Prof. Dr. Maria Laura Tanda
Dr. Daniela Gallo
Manuscript Submission Information
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- Graves’ disease
- Graves’ orbitopathy
- target therapies