Molecular Mechanisms in Neurodegenerative Diseases: Clinical and Therapeutic Perspectives—Volume II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 20 March 2024 | Viewed by 97

Special Issue Editors

ALS Centre, Neurology Unit, Maggiore della Carità University Hospital, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Interests: neurodegeneration; amyotrophic lateral sclerosis; biomarkers; genetics
Special Issues, Collections and Topics in MDPI journals
1. Neurology Unit, S. Andrea Hospital, Department of Translational Medicine, University of Piemonte Orientale, Vercelli, Italy
2. In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy
Interests: dementia; mild cognitive impairment; biomarkers; neurodegeneration; PET imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are progressive and debilitating conditions that result in inexorable neural degeneration and loss. To date, none of the existing therapeutic strategies can effectively stop or modify the pathological processes leading to neurodegeneration.

In recent decades, researchers have been trying to enhance the development of reliable biomarkers for neurodegenerative diseases, while medical practice has been moving toward precision medicine. However, there is still an urgent need to identify disease-specific biomarkers to improve the early diagnostic workup, favor clinical classification and prognostic models, and facilitate the development of effective disease-modifying therapies. Most neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, are characterized by the abnormal deposition of misfolded proteins in the central nervous system, resulting in neuronal degeneration and ultimately neuronal damage death. Several environmental factors have been proposed to contribute to neuronal damage and degenerative changes, and the genetic profile may also prepare the pathophysiological process underlying neurodegeneration. Distinct molecular and functional pathways may become dysregulated, including neurophysiology feedbacks, long-distance brain network organization, and neuroinflammatory responses. Pathology alterations can be detected, in vivo, by searching for cerebrospinal fluid alterations or using positron emission tomography to detect abnormal protein accumulation. Brain imaging can also reveal functional and molecular connectivity changes, and neurophysiology techniques may track additional early disease-specific dysfunctions. Genetic profiling can aid the identification of possible clinical trajectories along the neurodegenerative process, offering the possibility to test therapeutic strategies in a pre-symptomatic phase. Similarly, the investigation of neuroinflammatory responses represents a possible invaluable tool in monitoring disease progression and predicting clinical outcomes.

This Special Issue aims to highlight the current knowledge regarding neurodegeneration pathogenic mechanisms and underline possible diagnostic and therapeutic repercussions in neurodegenerative diseases.

In this Special Issue, original articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Fabiola De Marchi
Dr. Giacomo Tondo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegeneration
  • aging
  • dementia
  • motoneuron disease
  • movement disorders
  • precision medicine
  • biomarkers

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Published Papers

This special issue is now open for submission.
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