Clinical Prevention and Treatment of Osteoporosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (15 December 2020)

Special Issue Editors

Université de Paris, BIOSCAR UMR 1132, Inserm, F-75010 Paris, France
Interests: osteoporosis in elderly and young adults; rare bone diseases; interaction of bone and cartilage
Special Issues, Collections and Topics in MDPI journals
Department of Rheumatology, University of Barcelona, Barcelona, Spain
Interests: osteoporosis; bone biomarkers

Special Issue Information

Dear Colleagues,

The area of bone and mineral research faces several challenges. Osteoporosis remains a public health problem despite several advances provided by basic and clinical research and the development of new molecules. Skeletal fractures are the main consequences that impair quality of life, and constitute a high cost of health care in addition to personal and socioeconomic burden. Altered bone health is often associated with several risk factors, highlighting that bone status is part of the puzzle of general health. The recognition of individual clinical risk factors and scores is still missing to identify the population at high fracture risk, in particular those to target and who will benefit from treatments. This should include the development of potential new tools such as biochemical and imaging markers. In addition, other tools should be explored to facilitate the clinical management and improve the adherence and persistence to treatment. Evidence of the efficacy of sequential or combined treatment has been provided, but the modalities remain to be determined.

The role of environmental factors such as the microbiota and dietary habits is now challenging. Obesity, diabetes, and other diseases associated with a high prevalence of fractures provide a link between fat and energy metabolism and bone, the mechanisms and potential common biomarkers of which remain to be elucidated in order to translate to the clinic. 

In summary, the management of skeletal fractures remains a challenge in order to decrease the incidence and burden of osteoporosis. Progress in epidemiology and the development of new markers should facilitate a better understanding of bone loss and the development of new measures to evaluate risk and the response to treatment.

Prof. Dr. Martine Cohen-Solal
Prof. Nuria Guanabens
Guest Editors

Manuscript Submission Information

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Keywords

  • Osteoporosis
  • Imaging
  • Biomarkers
  • Epidemiology
  • Artificial intelligence
  • System biology
  • Rare bone diseases

Published Papers (1 paper)

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Review

27 pages, 532 KiB  
Review
Non-Pharmacological Interventions towards Preventing the Triad Osteoporosis-Falls Risk-Hip Fracture, in Population Older than 65. Scoping Review
by Alba Peraza-Delgado, María Begoña Sánchez-Gómez, Juan Gómez-Salgado, Macarena Romero-Martín, Mercedes Novo-Muñoz and Gonzalo Duarte-Clíments
J. Clin. Med. 2020, 9(8), 2329; https://doi.org/10.3390/jcm9082329 - 22 Jul 2020
Cited by 13 | Viewed by 3968
Abstract
Osteoporosis leads to increased risk of falls, and thus an increase in fractures, highlighting here hip fractures, that result in high mortality, functional disability, and high medical expenditure. The aim is to summarise the available evidence on effective non-pharmacological interventions to prevent the [...] Read more.
Osteoporosis leads to increased risk of falls, and thus an increase in fractures, highlighting here hip fractures, that result in high mortality, functional disability, and high medical expenditure. The aim is to summarise the available evidence on effective non-pharmacological interventions to prevent the triad osteoporosis/falls risk/hip fracture. A scoping review was conducted consulting the Scientific Electronic Library Online (Scielo), National Institute for Health and Care Excellence (NICE), Cumulative Index to Nursing & Allied Health Literature (CINAHL) y PubMed.databases. Inclusion criteria were articles published between 2013 and 2019, in Spanish or English. In addition, publications on a population over 65 years of age covering non-pharmacological interventions aimed at hip fracture prevention for both institutionalised patients in long-stay health centres or hospitals, and patients cared for at home, both dependent and non-dependent, were included. Sixty-six articles were selected and 13 non-pharmacological interventions were identified according to the Nursing Interventions Classification taxonomy, aimed at preventing osteoporosis, falls, and hip fracture. The figures regarding the affected population according to the studies are alarming, reflecting the importance of preventing the triad osteoporosis, falls risk, and hip fracture among the population over 65 years of age. The most effective interventions were focused on increasing Bone Mineral Density through diet, exercise, and falls prevention. As a conclusion, primary prevention should be applied to the entire adult population, with special emphasis on people with osteoporosis. Full article
(This article belongs to the Special Issue Clinical Prevention and Treatment of Osteoporosis)
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