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Special Issue "Endometriosis: Clinical Advances and Challenges"

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 15 August 2023 | Viewed by 3938

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Special Issue Editors

Prof. Dr. Anis Feki

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Guest Editor

Department of Obstetrics and Gynecology, Cantonal Hospital Fribourg, 1708 Fribourg, Switzerland
Interests: endometriosis; fertility; assisted reproductive medicine
Special Issues, Collections and Topics in MDPI journals

Dr. Arrigo Fruscalzo

E-Mail Website
Guest Editor

Department of Obstetrics and Gynecology, Cantonal Hospital Fribourg, 1708 Fribourg, Switzerland
Interests: endometriosis; elasticity imaging technology; pregnancy complications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis is one of the most common gynecological pathologies. Despite its benign nature, it is linked to extensive clinical, social and health financial burdens, mainly due to its elusiveness and its chronic development pathway. Despite current research efforts, diagnosis and treatment options still remain challenging. Thus, a bold research area exists to be explored in the expectation of improving the way we approach and treat this disease.

This Special Issue aims to provide a collection of manuscripts providing an overview of the current and evidence-based knowledge of endometriosis. These should cover all main issues of both endometriosis and adenomyosis, including the diagnosis, classification systems, as well as conservative and surgical therapies for pain and infertility concerns. Manuscripts approaching less-common topics, such as endometriosis during adolescence and menopause, extra-pelvic endometriosis, primary and secondary prevention strategies, new non-invasive diagnostic approaches or complementary and alternative therapies, are warmly encouraged. We welcome both original research articles and reviews.

Prof. Dr. Anis Feki
Dr. Arrigo Fruscalzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

endometriosis
adenomyosis
diagnosis
classification
therapy
progesterone
complementary therapies

Published Papers (5 papers)

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Open AccessArticle

Endometriosis and the Temporomandibular Joint—Preliminary Observations

and

J. Clin. Med. 2023, 12(8), 2862; https://doi.org/10.3390/jcm12082862 - 14 Apr 2023

Viewed by 640

Abstract

(1) Background: The complete picture of the disease is not fully recognized and extends far beyond the pelvis. The disease’s impacts lead to systemic inflammation, in turn resulting in sensitization to pain. The aim of this study was to check whether statistical correlations exist in women with endometriosis with regard to their experience of pain: headache, pelvic pain, temporomandibular joint pain, along with teeth clenching and the treatment of the disease. We constructed contingency tables, followed by Pearson’s chi-square test and Cramer’s V coefficient values. (2) Methods: A survey was conducted among 128 women aged 33.43 ± 5.79 with a diagnosis of endometriosis (disease duration 6.40 ± 5.88 years). (3) Results: There was a correlation between the occurrence of pain on the right and left sides of the pelvis and pain on the right and left sides of the temporomandibular joint, p-value = 0.0397, V = 0.2350, and between the presence of pelvic pain and the treatment of endometriosis, p-value = 0.0104, V = 0.3709, and between the presence of pain outside the pelvis and the treatment of endometriosis, p-value = 0.0311, V = 0.4549. There was a highly significant correlation between teeth clenching and temporomandibular joint pain, p-value = 0.0005, V = 0.3695. (4) Conclusions: The study revealed a correlation between pelvic endometriosis symptoms and symptoms in the temporomandibular joint. Full article

(This article belongs to the Special Issue Endometriosis: Clinical Advances and Challenges)

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Open AccessArticle

Pelvic Pain, Mental Health and Quality of Life in Adolescents with Endometriosis after Surgery and Dienogest Treatment

Elena P. Khashchenko

Elena V. Uvarova

Vladimir D. Chuprynin

Margarita Yu. Pustynnikova

Timur Kh. Fatkhudinov

and

J. Clin. Med. 2023, 12(6), 2400; https://doi.org/10.3390/jcm12062400 - 20 Mar 2023

Viewed by 910

Abstract

Background: Diagnostic and treatment delays have caused significant impacts on the physical and emotional well-being of adolescents with endometriosis, though such research is limited. This study aimed to assess the effects of one-year dienogest therapy on the clinical picture, pain patterns, psycho-emotional status, and quality-of-life indicators in adolescents with endometriosis after surgical treatment. Methods: The study enrolled 32 girls aged 13–17 with peritoneal endometriosis to analyze one-year dynamics of the Visual Analog Scale (VAS), McGill Pain Questionnaire, Beck Depression Scale (BDI), Hospital Anxiety and Depression Scale (HADS), Spielberger State-Trait Anxiety Inventory (STAI) and SF-36 quality-of-life survey scores along with clinical and laboratory indicators before surgery and after one-year dienogest therapy. Results. The therapy provided a significant alleviation of endometriosis-associated clinical symptoms, including dysmenorrhea, pelvic pain, gastrointestinal/dysuria symptoms, decreased everyday activity (<0.001), a decrease in anxiety/depression scores (BDI, HADS, STAI), and quality-of-life improvement (<0.001). These effects were accompanied by beneficial dynamics in hormone and inflammatory markers (prolactin, cortisol, testosterone, estradiol, CA-125, neutrophil/lymphocyte ratio; <0.005) within reference ranges. A low body mass index and high C-reactive protein levels were associated with higher VAS scores; a high estradiol level was a factor for anxiety/depression aggravation (<0.05). Conclusions: Dienogest, after surgical treatment, significantly improved quality of life and reduced pain symptoms while showing good tolerability and compliance, and reasoning with timely hormonal therapy in adolescents with endometriosis. Full article

(This article belongs to the Special Issue Endometriosis: Clinical Advances and Challenges)

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Open AccessArticle

Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study

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J. Clin. Med. 2023, 12(5), 1829; https://doi.org/10.3390/jcm12051829 - 24 Feb 2023

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Abstract

Objective: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. Materials and Methods: It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche). Results: The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL; p = 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL, p = 0.41). No significant correlation between the follicular IL6 and AMH levels was observed. Conclusions: The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes. Full article

(This article belongs to the Special Issue Endometriosis: Clinical Advances and Challenges)

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Open AccessSystematic Review

Radiofrequency Ablation for Adenomyosis

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J. Clin. Med. 2023, 12(9), 3069; https://doi.org/10.3390/jcm12093069 - 23 Apr 2023

Viewed by 624

Abstract

Adenomyosis is a common benign gynecologic condition characterized by ectopic endometrial glands and stroma in the myometrium causing pain (dysmenorrhea) and abnormal uterine bleeding. New interventional techniques have been introduced over recent years. This study evaluates the treatment success and side effects of radiofrequency ablation. An electronic literature search in the PubMed, Scopus, and ScienceDirect databases was carried out on the outcomes of pain reduction and, secondarily, on abnormal uterine bleeding, reintervention, reproductive outcome, imaging outcome, and complications. There was a mean decrease in dysmenorrhea pain scores by −63.4 ± 9.0% at 12 months. Data on other outcome parameters were sparse. No major complications were reported. Radiofrequency ablation represents a promising minimally invasive and organ-preserving treatment in patients with symptomatic adenomyosis. It is associated with clinically meaningful improvement of adenomyosis-related pain in the short term. Full article

(This article belongs to the Special Issue Endometriosis: Clinical Advances and Challenges)

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Open AccessBrief Report

Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis

Vincenzo Brescia Morra

Roberta Lanzillo

Antonio Carotenuto

Francesca Boscia

Maurizio Taglialatela

and

Maurizio Guida

J. Clin. Med. 2023, 12(5), 2043; https://doi.org/10.3390/jcm12052043 - 04 Mar 2023

Viewed by 680

Abstract

Objective: To report for the first time an Italian epidemiological analysis of the prevalence of multiple sclerosis (MS) in patients with endometriosis (EMS), through the study of the endometriosis population of our referral center; to analyze the clinical profile and perform a laboratory analysis to examine the immune profile and the possible correlation to other autoimmune diseases of the enrolled patients. Methods: We evaluated 1652 women registered with EMS in the University of Naples Federico II and retrospectively searched patients with a co-diagnosis of MS. Clinical features of both conditions were recorded. Serum autoantibody and immune profiles were analyzed. Results: 9 out of 1652 patients presented a co-diagnosis of EMS and MS (9/1652 = 0.005%). Clinically, EMS and MS presented in mild forms. Hashimoto’s thyroiditis was found in two patients (2/9). Even if not statistically significant, a trend of variation in CD4- CD8 T lymphocytes and of B cells were found. Conclusion: Our findings suggest an increased risk of MS in women with EMS. However, large-scale prospective studies are needed. Full article

(This article belongs to the Special Issue Endometriosis: Clinical Advances and Challenges)

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