Placenta-Mediated Conditions of Pregnancy: Prevention, Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 129

Special Issue Editor

Dr. Amihai Rottenstreich
E-Mail Website
Guest Editor
1. Maternal Fetal Medicine Service, Northwell Health, New York, NY 11042, USA
2. Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA
Interests: maternal fetal medicine; obstetric medicine; placenta-mediated complications; bleeding and thrombotic complications of pregnancy; preterm birth; perinatology

Special Issue Information

Dear Colleagues,

Placenta-mediated conditions include hypertensive disorders of pregnancy, fetal growth restriction, placental abruption, and late pregnancy loss. These complications are leading causes of maternal, fetal, and neonatal morbidity and mortality worldwide. In recent decades, many efforts have been made in order to improve the prevention, diagnosis and management of placenta-mediated conditions. Despite significant advancements and the accumulation of a large body of evidence, many other issues remain that must be addressed.

In this Special Issue of the Journal of Clinical Medicine, we are offering a platform to highlight the broad diversity of research performed across this field. This Special Issue will focus on new insights, current challenges and controversies, recent advances, and future perspectives in the field of placenta-mediated conditions. We anticipate that the research presented will promote fruitful discussions in the maternal–fetal medical community that will translate into the adoption of best practice applications in clinical, public health and policy settings.

Dr. Amihai Rottenstreich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • placenta-mediated conditions
  • preeclampsia
  • fetal growth restriction
  • placental abruption
  • pregnancy loss

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Influence of preoperative twin anemia polycythemia sequence on twin-twin transfusion syndrome outcome
Authors: Javier U. Ortiz; Oliver Graupner; Johanna Guggenberger; Eva Ostermayer; Bettina Kuschel; Silvia M. Lobmaier
Affiliation: Division of Obstetrics and Perinatal Medicine, Department of Obstetrics and Gynecology, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany
Abstract: Monochorionic twin pregnancy is a unique condition in which two fetuses share a placenta. Placental vascular anastomoses can lead to blood volume and/or hematological imbalance between fetuses. The objective of this study was to evaluate the outcome of twin-twin transfusion syndrome (TTTS) with and without preoperative twin anemia polycythemia sequence (TAPS). For this purpose, a retrospective cohort study including 92 monochorionic diamniotic twins and three dichorionic triamniotic triplets undergoing laser therapy in a single tertiary center was conducted. Of 95 TTTS pregnancies, eight twin pairs (8%) had preoperative TAPS. There were no significant differences in miscarriage (0% vs. 5%), premature rupture of membranes > 32 weeks (50% vs. 36%), premature delivery < 32 weeks (37% vs. 47%), gestational age at delivery (33.0 vs. 32.4 weeks), overall twin survival (94% vs. 81%), survival of at least one twin (100% vs. 93%), double survival (88% vs. 69%), donor survival (88% vs. 75%), and recipient survival (100% vs. 87%) between the groups. In conclusion, TTTS outcome after laser surgery was not impacted by the presence of preoperative TAPS.

Title: The role of single nucleotide polymorphisms of IL-6, IL-10, and TNF alpha in the incidence of spontaneous premature birth
Authors: Mirta Kadivnik; Deni Plečko; Andrijana Muller; Nena Arvaj; Kristina Kralik; Jasenka Wagner
Affiliation: Faculty of Medicine Osijek, Clinical Hospital center Osijek, Croatia
Abstract: Objective: Premature birth is the most common cause of perinatal mortality and morbidity. It has been shown that there is an influence of certain cytokines on the maintenance of pregnancy. Specific genes regulate certain cytokines, therefore polymorphisms in the mother were investigated to prove a possible association between them and premature birth. The association of gene variants for IL-6 (rs1800796), IL-10 (1800896), and TNF-alpha (1800629) with the occurrence of spontaneous preterm birth were examined. Methods: The study includes a total of 400 mothers (200 mothers in the control group and 200 mothers with sPB). Three SNPs of investigated cytokines have been determined in mothers. These SNPs were analyzed using a real-time PCR instrument and TaqMan reagent kits. The study is conducted as a case-control study.

Title: From placental role in mineral metabolism to pregnancy-related primary hyperparathyroidism
Authors: Mara Carsote 1,2; Oana-Claudia Sima 2,3; Ana-Maria Gheorghe 2,3; Alexandra-Ioana Trandafir 2,3; Eugenia Petrova 1,2; Adina Ghemigian 1,2
Affiliation: 1. Department of Endocrinology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2. Department of Clinical Endocrinology, “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania 3. PhD Doctoral School, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Abstract: "The abstract is the final step since it is the most important and I hope I finish the work as soon as possible. "

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