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Latest Advances in Endoscopic Imaging and Therapy—Part II
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Latest Advances in Endoscopic Imaging and Therapy—Part II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (10 September 2023) | Viewed by 8315

Special Issue Editor

Prof. Dr. Hajime Isomoto

E-Mail Website
Guest Editor
Division of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
Interests: narrow-band imaging (NBI); blue laser imaging (BLI); linked color imaging (LCI); image-enhanced endoscopies (IEE); artificial intelligence (AI); computer-aided diagnosis (CAD); endoscopic submucosal dissection (ESD); endocytoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, research on image-enhanced endoscopy (IEE) has reported benefits regarding the accuracy and reproducibility of endoscopic diagnosis for gastrointestinal (GI) tumors and premalignant lesions. The latest advances in imaging modalities in GI endoscopy have mainly been associated with the development of artificial intelligence (AI), and computer-aided diagnosis (CAD) is garnering increased investigation. Accurate endoscopic diagnosis is effective for discriminating the GI tract tumor margin before endoscopic resection, while endocytoscopy enables the production of real-time in vivo histologic images under ultra-magnification.

In the coming years, next-generation endoscopy is anticipated to integrate robotic-assisted devices, AI technology, preventive medicine, and informative genomic medicines. The available IEE techniques include narrow-band imaging (NBI), blue laser imaging (BLI), linked color imaging (LCI), and infra-red imaging (IRI) for immune and inflammatory diseases and intractable conditions such as achalasia. Unraveling carcinogenesis with endoscopic sampling will provide new insights and open the door for translational research in this Special Issue, which is a continuation of an incredibly successful Special Issue. Using secure diagnostic modalities, endoscopic submucosal dissection (ESD) for diverse GI tumors could be standardized, while longer outcomes and merits will be underscored in particular progressive super-elderly societies.

This Special Issue, Part II, aims to disseminate knowledge on how endoscopic imaging is being developed to provide readers with a view of the future of diagnostic luminal endoscopy and to present the latest advancements in endoluminal therapeutic techniques. Endoscopic innovations are of particular interest.

Prof. Dr. Hajime Isomoto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • narrow-band imaging (NBI)
  • blue laser imaging (BLI)
  • linked color imaging (LCI)
  • image-enhanced endoscopies (IEE)
  • artificial intelligence (AI)
  • computer-aided diagnosis (CAD)
  • endoscopic submucosal dissection (ESD)
  • endocytoscopy
  • translational research
  • immune and inflammatory conditions
  • elderly
  • preventive medicines
  • genomic and epigenetic medicines
  • carcinogenesis

Related Special Issue

Published Papers (6 papers)

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Research

9 pages, 1835 KiB  
Article
Does an Extraoral Suction Device Reduce Aerosol Generation and Prevent Droplet Exposure to the Examiner during Esophagogastroduodenoscopy?
by Shintaro Fujihara, Hideki Kobara, Noriko Nishiyama, Naoya Tada, Yasuhiro Goda, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Nobuya Kobayashi, Tatsuo Yachida and Tsutomu Masaki
J. Clin. Med. 2023, 12(7), 2574; https://doi.org/10.3390/jcm12072574 - 29 Mar 2023
Viewed by 1140
Abstract
Esophagogastroduodenoscopy (EGD) is an aerosol-generating procedure. A major challenge in the COVID-19 era is how to prevent the spread of aerosols and droplets in endoscopic units. We evaluated the effectiveness of an extraoral suction device in preventing indoor aerosol diffusion and droplet exposure [...] Read more.
Esophagogastroduodenoscopy (EGD) is an aerosol-generating procedure. A major challenge in the COVID-19 era is how to prevent the spread of aerosols and droplets in endoscopic units. We evaluated the effectiveness of an extraoral suction device in preventing indoor aerosol diffusion and droplet exposure for examiners. The study involved 61 patients who underwent EGD at our institution from 1 February to 31 March 2022. To determine whether aerosol spread increases before or after EGD examination with an extraoral suction device located in front of the patient’s mouth, aerosols of 0.3, 0.5, 1, 3, 5, and 10 μm were measured with a handheld particle counter. The degree of contamination of the plastic gowns on the examiners was assessed using the rapid adenosine triphosphate test. The extraoral suction device significantly reduced the diffusion of large particles (3, 5, and 10 μm) after finishing the EGD examination. However, the diffusion of small particles (0.3 and 0.5 μm) was significantly increased. This extraoral suction device was effective in reducing large particle diffusion during EGD examination but was limited for minimizing small particle diffusion or droplet exposure to the examiner. Full article
(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part II)
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10 pages, 1731 KiB  
Article
Comparison of Needle Knife versus Scissors Forceps for Colorectal Endoscopic Submucosal Dissection: A Prospective Randomized Study
by Tatsuo Yachida, Hideki Kobara, Kazuhiro Kozuka, Kaho Nakatani, Naoya Tada, Takanori Matsui, Taiga Chiyo, Nobuya Kobayashi, Shintaro Fujihara, Noriko Nishiyama, Akihiro Kondo, Yasuhisa Ando, Keiichi Okano, Wakako Nonaka, Kaori Ishikawa, Hisashi Masugata and Tsutomu Masaki
J. Clin. Med. 2023, 12(6), 2329; https://doi.org/10.3390/jcm12062329 - 16 Mar 2023
Cited by 1 | Viewed by 1525
Abstract
Background and Aim: To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). Methods: This was a randomized prospective study. Patients who underwent C-ESD for colorectal neoplasms >20 mm and <50 mm in [...] Read more.
Background and Aim: To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). Methods: This was a randomized prospective study. Patients who underwent C-ESD for colorectal neoplasms >20 mm and <50 mm in size were enrolled, dividing into two groups: ESD using needle type of dual knife alone (D-group) and circumferential incision using dual knife followed by submucosal dissection using CC (CC-group). The primary outcome was the self-completion rate. The secondary outcomes were intraoperative complication rate, procedure time, and en bloc resection rate. Results: A total of 45 patients were allocated to the D-group and 43 to the CC-group were allocated. The self-completion rate was higher in the CC-group (87% [39/45] vs. 98% [42/43]). All of the six patients with an incomplete procedure in the D-group were completely resected with CC use. The intraoperative complication rate was not significant in either group (D vs. CC: 2% vs. 0%). The mean procedure time was significantly shorter in the D-group than that in the CC-group (62.0 vs. 81.1 min; p = 0.0036). The en bloc resection rate was 100% in the D-group and 98% in the CC-group. Conclusions: While dual knife use is superior to CC in terms of time efficiency, the use of CC may be a safe and efficacious option for achieving complete C-ESD. Full article
(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part II)
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11 pages, 1507 KiB  
Article
Comparison between Target Sample Check Illuminator and White Light Observation in Discriminating the Presence of Target Specimen for Endoscopic Ultrasound-Guided Fine Needle Aspiration Sample
by Hiroki Koda, Kazuya Matsumoto, Soichiro Kawata, Yohei Takeda, Takumi Onoyama, Yuta Seki, Yuri Sakamoto, Takuya Shimosaka, Wataru Hamamoto, Taro Yamashita, Hiroki Kurumi, Naoyuki Yamaguchi, Hisashi Noma and Hajime Isomoto
J. Clin. Med. 2023, 12(6), 2139; https://doi.org/10.3390/jcm12062139 - 09 Mar 2023
Cited by 1 | Viewed by 893
Abstract
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an essential endoscopic tissue sampling method for diagnosing pancreatobiliary diseases; however, determining the presence of target specimens mixed in the blood by conventional observation is challenging due to the small size of the obtained sample. This [...] Read more.
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an essential endoscopic tissue sampling method for diagnosing pancreatobiliary diseases; however, determining the presence of target specimens mixed in the blood by conventional observation is challenging due to the small size of the obtained sample. This study investigated the usefulness of a target sample check illuminator (TSCI) that emits a specific wavelength of light to determine the presence of target specimens. Twenty-seven patients who underwent EUS-FNA at our hospital were included. Conventional white light observation was performed for the collected samples, followed by TSCI; six people evaluated the presence of the target specimen on a 5-point scale. The target specimen discrimination score using TSCI (median: 5) was significantly higher than that using conventional white light observation (median: 1) (p < 0.001). No significant difference was observed in the discrimination score between the evaluator (novice vs. expert, p = 0.162) and puncture needle (22G vs. 25G, p = 0.196). The discriminability of TSCI in the samples obtained using EUS-FNA was significantly higher than that of conventional observation. TSCI does not depend on the evaluator or puncture needle for the identification of the target specimen; hence, it can provide a good pathological specimen and may contribute to the improvement of the diagnostic ability. Full article
(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part II)
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15 pages, 1404 KiB  
Article
The Feasibility and Safety of Endoscopic Submucosal Dissection for Circumferential Superficial Esophageal Squamous Cell Neoplasms
by Yi Liu, Lizhou Dou, Wei Rao, Yong Liu, Yueming Zhang, Shun He, Liyan Xue and Guiqi Wang
J. Clin. Med. 2023, 12(2), 471; https://doi.org/10.3390/jcm12020471 - 06 Jan 2023
Cited by 4 | Viewed by 1427
Abstract
Background It remains controversial whether endoscopic submucosal dissection (ESD) is still appropriate for circumferential superficial esophageal squamous cell neoplasms (SESCN), and few studies compared the short-term and long-term outcomes of ESD with radical surgery. Methods A total of 140 patients with SESCN who [...] Read more.
Background It remains controversial whether endoscopic submucosal dissection (ESD) is still appropriate for circumferential superficial esophageal squamous cell neoplasms (SESCN), and few studies compared the short-term and long-term outcomes of ESD with radical surgery. Methods A total of 140 patients with SESCN who underwent ESD or surgery between February 2014 and October 2021 were retrospectively reviewed. The characteristics of patients, operative time, postoperative complications, overall survival (OS), recurrence-free survival (RFS), and quality of life (QOL) were compared between the ESD and surgery groups. The effect of different methods to prevent esophageal stenosis after ESD were analysed. Results Drinking, family history of cancer, macroscopic type, and intrapapillary capillary loop (IPCL) type were independent risk factors for deep submucosal invasion (SM ≥ 200 μm). Smoking and IPCL type were independent predictive factors for angiolymphatic invasion. The average operative time of ESD was significantly shorter than that of surgery (174.5 ± 51.16 min vs. 255.9 ± 88.18 min, p < 0.001). The incidence of perioperative complications in ESD group was significantly lower than that in surgery group (5.5% vs. 19.4%, p = 0.015). The ESD group had significantly better functional scale scores for emotional functioning, cognitive functioning, and global health status, and lower rates of pain, dyspnoea, insomnia, appetite loss, diarrhoea, reflux, and trouble with taste than the surgery group. No significant difference in OS and RFS between ESD and surgery group. Conclusions ESD can significantly shorten the operative time and reduce perioperative complications. Additionally, on the premise of using appropriate measures to prevent postoperative stenosis, ESD can be the first choice for the treatment of SESCN, which could provide better QOL, and the long-term prognosis of ESD is no less than that of surgery. Full article
(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part II)
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11 pages, 1187 KiB  
Article
The Advantage of Immunohistochemical Staining for Evaluating Lymphovascular Invasion Is Limited for Patients with Esophageal Squamous Cell Carcinoma Invading the Muscularis Mucosa
by Akira Dobashi, Daisuke Aizawa, Yuko Hara, Hiroto Furuhashi, Hiroaki Matsui, Toshiki Futakuchi, Shingo Ono, Hirobumi Toyoizumi, Fateh Bazerbachi, Takashi Yamauchi, Machi Suka and Kazuki Sumiyama
J. Clin. Med. 2022, 11(23), 6969; https://doi.org/10.3390/jcm11236969 - 25 Nov 2022
Cited by 1 | Viewed by 1238
Abstract
The cumulative metastasis rate of esophageal squamous cell carcinoma (ESCC) pathologically invading the muscularis mucosae (pT1a-MM), based on lymphovascular invasion (LVI) evaluated by immunohistochemical (IHC) staining is unknown. This retrospective study included patients with endoscopically resected pT1a-MM ESCC. The primary endpoint was the [...] Read more.
The cumulative metastasis rate of esophageal squamous cell carcinoma (ESCC) pathologically invading the muscularis mucosae (pT1a-MM), based on lymphovascular invasion (LVI) evaluated by immunohistochemical (IHC) staining is unknown. This retrospective study included patients with endoscopically resected pT1a-MM ESCC. The primary endpoint was the metastasis rate of pT1a-MM based on LVI, evaluated using IHC and additional prophylactic therapy. The secondary endpoint was the identification of independent factors for metastasis based on lesion characteristics. The prognosis was also analyzed considering the impact of head and neck cancer. A total of 104 patients were analyzed, with a median follow-up of 74 months. The positive rate for LVI was 43.3% (45/104). In 33 patients, IHC was not performed at the time of clinical evaluation, 8 of whom exhibited LVI. However, these patients did not exhibit metastasis. The metastasis rates of patients without LVI, those with LVI and additional therapy, and those with LVI without additional therapy were 5.1%, 20.8%, and 0%, respectively. Lesion size ≥ 25 mm was the only independent factor for metastasis in multivariate analysis. The advantage of IHC for determining additional prophylactic therapy is limited for patients with pT1a-MM ESCC. Full article
(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part II)
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12 pages, 526 KiB  
Article
Comparison of Endoscopic Submucosal Dissection and Radical Surgery for Early Gastric Cancer in Remnant Stomach
by Yi Liu, Zhihao Chen, Hong Zhou, Yingtai Chen, Lizhou Dou, Yueming Zhang, Yong Liu, Shun He, Dongbing Zhao and Guiqi Wang
J. Clin. Med. 2022, 11(18), 5403; https://doi.org/10.3390/jcm11185403 - 14 Sep 2022
Cited by 2 | Viewed by 1389
Abstract
(1) Background: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the remnant stomach or gastric tube is not yet widespread and few studies have compared the short-term and long-term outcomes with radical surgery. (2) Methods: A total of 73 consecutive patients [...] Read more.
(1) Background: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the remnant stomach or gastric tube is not yet widespread and few studies have compared the short-term and long-term outcomes with radical surgery. (2) Methods: A total of 73 consecutive patients with EGC in the remnant stomach or gastric tube who underwent ESD or radical surgery between October 2009 and October 2020 were retrospectively analyzed in this study. Baseline characteristics, post-operative complications, quality of life (QOL), recurrence rate, overall survival (OS) and disease-free survival (DFS) were compared between the ESD and surgery groups. (3) Results: Among the 73 patients with EGC in the remnant stomach or gastric tube, 48 (65.8%) underwent ESD and 25 (34.2%) underwent surgery. The operation time (p = 0.000) and post-operative hospital stay (p = 0.002) of the ESD group were significantly shorter than those in the surgery group. The incidence of post-operative complications in the ESD group was significantly lower than that in surgery group (p = 0.001). The ESD group had significantly better functional scale scores and lower rates of fatigue, pain, appetite loss, financial difficulties, dysphagia, eating restrictions, hair loss, and poor body image than the surgery group. There was no significant difference in OS or DFS between the ESD and surgery groups (p = 0.124 and 0.344, respectively). (4) Conclusion: ESD can significantly shorten the operation time and hospital stay, reduce surgical complications, and provide better QOL for patients with EGC in the remnant stomach or gastric tube, and its long-term prognosis is no shorter than that of radical surgery. Full article
(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part II)
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