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Special Issues
Recent Advances and Challenges in Pancreatic Surgery
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Special Issue "Recent Advances and Challenges in Pancreatic Surgery"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 20 October 2023 | Viewed by 791

Special Issue Editors

Dr. Masayuki Tanaka

E-Mail Website
Guest Editor
Department of Surgery, Keio University School of Medicine, Tokyo 108-8345, Japan
Interests: pancreatic surgery; conversion surgery
Dr. Yutaka Endo

E-Mail
Guest Editor
Department of Surgery, Keio University School of Medicine, Tokyo 108-8345, Japan
Interests: pancreatic cancer; liver cancer; liver transplantation

Special Issue Information

Dear Colleagues,

Effective chemotherapy protocols as induction treatment provide increasing opportunities for curative resection of borderline-resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC). Although improved survival after resection of BRPC and LAPC with chemotherapy has been reported, reliable recommendations on the indication for induction treatment and surgical treatment are currently lacking. The current definitions of BRPC and LAPC focus only on the anatomic factors and not on the biology of the tumor. The scope of this Special Issue is to stratify resectable PC, BRPC, and LAPC in terms of biological behavior for the revision of definition.

For this Special Issue, I would like to invite authors to submit studies focusing on the new categorization and surgical indication. Authors are welcome to cover other specific topics that have not been mentioned but fall within the theme of the Special Issue.

Dr. Masayuki Tanaka
Dr. Yutaka Endo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatic cancer;
  • conversion surgery;
  • borderline resectable;
  • unresectable locally advanced;
  • neoadjuvant treatment

Published Papers (1 paper)

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Research

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Article
Influence of Hemorrhagic Complications of Pancreatoduodenectomy in Patients with Cancer on Short- and Long-Term Mortality
by
Alexandre Thobie
,
Fabien Robin
,
Benjamin Menahem
,
Jean Lubrano
,
Karim Boudjema
,
Arnaud Alves
,
Olivier Dejardin
and
Laurent Sulpice
J. Clin. Med. 2023, 12(8), 2852; https://doi.org/10.3390/jcm12082852 - 13 Apr 2023
Viewed by 622
Abstract
Background: With a mortality rate of up to 30%, post-pancreatectomy hemorrhage (PPH) remains a serious complication after pancreatoduodenectomy (PD) for cancer. Little is known about the long-term survival of patients after PPH. This retrospective study aimed to evaluate the impact of PPH on [...] Read more.
Background: With a mortality rate of up to 30%, post-pancreatectomy hemorrhage (PPH) remains a serious complication after pancreatoduodenectomy (PD) for cancer. Little is known about the long-term survival of patients after PPH. This retrospective study aimed to evaluate the impact of PPH on long-term survival after PD. Methods: The study included 830 patients (PPH, n = 101; non-PPH, n = 729) from two centers, who underwent PD for oncological indications. PPH was defined as any bleeding event occurring within 90 days after surgery. A flexible parametric survival model was used to determine the evolution of the risk of death over time. Results: At postoperative day 90, PPH significantly increased the mortality rate (PPH vs. non-PPH: 19.8% vs. 3.7%, p < 0.0001) and severe postoperative complication rate (85.1% vs. 14.1%, p < 0.0001), and decreased median survival (18.6 months vs. 30.1 months, p = 0.0001). PPH was associated with an increased mortality risk until the sixth postoperative month. After this 6-month period, PPH had no more influence on mortality. Conclusions: PPH had a negative impact on the short-term overall survival beyond postoperative day 90 and up to six months after PD. However, compared to non-PPH patients, this adverse event had no impact on mortality after a 6-month period. Full article
(This article belongs to the Special Issue Recent Advances and Challenges in Pancreatic Surgery)
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