Special Issue "The Pathogenesis and Prevention and Treatment of Coronary Heart Disease and Structural Heart Disease"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 974

Special Issue Editors

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Interests: hemodynamics in the pathogenesis of coronary heart disease; biophysical mechanisms of thrombosis and thrombotic complications after device implantation in cardiovascular system; clinical trials and basic research for novel treatments of heart failure
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
Interests: basic research and disease maker identification in cardiovascular and metabolic diseases
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
Interests: diagnosis, treatment, and the prediction of prognosis for coronary artery disease and structural heart disease

Special Issue Information

Dear colleagues,

Cardiovascular disease, especially coronary heart disease and structural heart disease, remains the leading cause of global mortality and morbidity and represents a major economic burden on health-care systems. Recently, a large number of clinical trials have emerged to demonstrate the benefit of new drugs and devices in treating these diseases. Furthermore, numerous basic studies also explored the mechanisms involving disease development in part. However, the major mechanisms and issues remain unknown.

With this Special Issue, we welcome clinical trials and mechanism studies of coronary heart diseases and structural heart disease. Furthermore, intervention and surgery are two main treatments of coronary heart disease and structural heart disease, and so part of this Special Issue will be also dedicated to research on these treatments, including — but not limited to — PCI, CABG, TAVR, SAVR, TEER, and TMVR.

We welcome original research articles reporting results from basic, clinical, and translational studies, as well as expert review articles that explore the mechanism, diagnosis, treatment, and the prediction of prognosis for coronary heart diseases and structural heart disease.

Dr. Junxia Zhang
Dr. Hongsong Zhang
Dr. Xiaofei Gao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary heart disease
  • structural heart disease
  • pathogenesis
  • prevention
  • treatment

Published Papers (1 paper)

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Review

Review
Microcirculatory Disease in Patients after Heart Transplantation
J. Clin. Med. 2023, 12(11), 3838; https://doi.org/10.3390/jcm12113838 - 04 Jun 2023
Viewed by 642
Abstract
Although the treatment and prognosis of patients after heart transplantation have significantly improved, late graft dysfunction remains a critical problem. Two main subtypes of late graft dysfunction are currently described: acute allograft rejection and cardiac allograft vasculopathy, and microvascular dysfunction appears to be [...] Read more.
Although the treatment and prognosis of patients after heart transplantation have significantly improved, late graft dysfunction remains a critical problem. Two main subtypes of late graft dysfunction are currently described: acute allograft rejection and cardiac allograft vasculopathy, and microvascular dysfunction appears to be the first stage of both. Studies revealed that coronary microcirculation dysfunction, assessed by invasive methods in the early post-transplant period, correlates with a higher risk of late graft dysfunction and death during long-term follow-up. The index of microcirculatory resistance, measured early after heart transplantation, might identify the patients at higher risk of acute cellular rejection and major adverse cardiovascular events. It may also allow optimization and enhancement of post-transplantation management. Moreover, cardiac allograft vasculopathy is an independent prognostic factor for transplant rejection and survival rate. The studies showed that the index of microcirculatory resistance correlates with anatomic changes and reflects the deteriorating physiology of the epicardial arteries. In conclusion, invasive assessment of the coronary microcirculation, including the measurement of the microcirculatory resistance index, is a promising approach to predict graft dysfunction, especially the acute allograft rejection subtype, during the first year after heart transplantation. However, further advanced studies are needed to fully grasp the importance of microcirculatory dysfunction in patients after heart transplantation. Full article
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