Deep Brain Stimulation for Parkinson’s Disease and Other Movement Disorders: The Long Road toward Personalized Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 27 March 2024 | Viewed by 126

Special Issue Editors

Dr. Carlo Alberto Artusi
E-Mail Website
Guest Editor
Department of Neuroscience Rita Levi Montalcini, University of Turin, 10124 Turin, Italy
Interests: Parkinson’s disease; dystonia; tremor; movement disorders; deep brain stimulation; neuromodulation
Dr. Margherita Fabbri
E-Mail Website
Guest Editor
Department of Neurosciences, Clinical Investigation Center CIC 1436, Parkinson Toulouse Expert Center, NS-Park/FCRIN Network and NeuroToul COEN Center, TOULOUSE University Hospital, INSERM, University of Toulouse 3, 31062 Toulouse, France
Interests: apomorphine; Parkinson's disease; cognitive impairment
Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy
Interests: non-invasive brain stimulation; neurophysiology; movement disorders; dementia; transcranial magnetic stimulation; transcranial electrical stimulation; electroencephalography
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Special Issue Information

Dear Colleagues,

Deep Brain Stimulation (DBS) is a valid therapy for Parkinson's disease (PD), dystonia, and invalidating tremor, and is also an emerging treatment for other movement disorders. However, several challenges still remain in order to maximize the benefit from DBS, including but not limited to the optimal selection of candidates, the most appropriate anatomical target, the knowledge of network modulation, the use of novel devices, and the potentiality of advanced or novel parameter settings, as well as the role of phenotype, genetics, and other clinical aspects, including motor and nonmotor symptoms, in determining DBS outcome.

This Special Issue aims to collect different types of articles exploring the efficacy and safety of DBS in uncommon movement disorders, offering deeper knowledge on the underlying mechanisms of DBS, including the modulation of neural networks and neuroplasticity, and addressing the challenges associated with achieving personalized medicine in DBS for movement disorders by investigating various factors that contribute to inter-individual variability in treatment outcomes, such as patient-specific anatomy, electrode placement, stimulation parameters, and disease progression. This Special Issue also welcomes studies on the role of advanced technologies, such as neuroimaging and electrophysiology, in optimizing DBS therapy, as well as high-quality reviews of the existing literature on DBS for PD and other movement disorders aimed at clarifying the efficacy and safety of DBS, its impact on motor and nonmotor symptoms, and its potential for improving the quality of life of patients. The ultimate goal of this Special Issue is to advance our understanding of DBS as a personalized treatment approach for Parkinson's disease, dystonia, tremor, and other movement disorders. By identifying key factors that influence treatment outcomes, we aspire to pave the way for tailored therapies that can maximize the benefits of DBS while minimizing its adverse effects.

Dr. Carlo Alberto Artusi
Dr. Margherita Fabbri
Dr. Andrea Guerra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Deep Brain Stimulation
  • movement disorders
  • personalized medicine
  • Parkinson’s disease
  • dystonia
  • tremor

Published Papers

This special issue is now open for submission.
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