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Special Issue "Clinical and Physiological Consequences of Hypoxia/Hypoxemia in Healthy Subjects and Patients"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".
Deadline for manuscript submissions: closed (10 May 2023) | Viewed by 12123
Special Issue Editors
Interests: exercise physiology; extreme environments; high-altitude medicine
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Interests: sleep medicine; physiology; neurology; rehabilitation medicine; altitude; hypoxia
Interests: human physiology; altitude; hypoxia; cardiorespiratory diseases
Special Issue Information
Low arterial oxygen content, termed hypoxemia, is often closely linked to respiratory or cardiovascular diseases or environmental conditions (high altitude, air travel). Hypoxemia has broad clinical and physiological consequences. It leads to insufficient availability of oxygen in tissues (hypoxia) and, therefore, may alter brain functionality, induce tissue remodeling and destruction, result in organ dysfunction and might promote progression of morbidity and mortality.
Diseases associated with hypoxemia are highly prevalent (COVID-19, chronic obstructive pulmonary disease, pulmonary hypertension, sleep apnea syndrome). Moreover, millions of people are living at high altitude places worldwide (8 million alone in Bogotá, 2640 m, Columbia). Intriguingly, current recommendations in patients with COPD recommend long-term oxygen therapy when the resting PaO2 value is <7.3 kPa (55 mmHg) or SaO2 <89 %, independent of living altitude. Moreover, the lack of well-designed studies complicates recommendations for patients with pre-existing cardiopulmonary diseases planning mountain sojourns, as well as treatments of patients permanently living at high-altitude places. On the other side, hypoxemia is not always deleterious; therefore, patients with ischemic heart disease might have a lower mortality rate when living at higher altitude (Ezzatti 2012, J Epidemiol Community Health). In accordance, millions of people migrate to higher altitudes, but not all of them have hypoxemic maladaptations; therefore, the pathways of hypoxemia are multifactorial and need more attention.
This Special Issue has the following aims:
1) To provide deep insights into the consequences of hypoxemia and hypoxia on the clinical, physiological and molecular level in humans.
2) To connect multiple areas of research and to improve evidence-based medicine in patients and highlanders suffering from hypoxemia.
3) To acquire a comprehensive understanding; to be able to improve current recommendations to prevent, treat or promote hypoxemia; to counsel patients planning to fly or live at high altitude; to protect healthy highlanders from suffering damage from chronic hypoxemia and hypoxia.
To accomplish these aims, we invite all research performed in humans focusing on the clinical, physiological and molecular level in any disease or condition related to or caused by hypoxemia and hypoxia. We welcome all forms of submissions: original research articles and review articles.
Prof. Dr. Martin Burtscher
Dr. Sébastien Baillieul
Dr. Michael Furian
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxygen deficit
- hypobaric hypoxia
- normobaric hypoxia