Special Issue "Current Issues and Future Developments in the Surgical Treatment of Upper Gastrointestinal Tract Cancer"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 25 January 2024 | Viewed by 1814

Special Issue Editors

Department of Surgery, Campus Charité Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany
Interests: gastro-esophageal cancer; obesity surgery; laparoscopic gastrointestinal surgery; complex ab-dominal hernia surgery
Department of Surgery, Campus Virchow Klinikum/Campus Charite Mitte, Charite University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Interests: surgical oncology; upper GI cancer; esophageal cancer; gastric cancer; clinical trials; minimally invasive surgery; robotic surgery
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Special Issue Information

Dear Colleagues,

Upper gastrointestinal tract surgery is constantly evolving with robotic surgery, and is gaining in importance. At the same time, laparoscopic techniques have been implemented as the standard approach for both early and advanced tumor stages. While anastomotic techniques and the extent of lymph node dissection are currently debated, the management and prevention of complications and failure to rescue play an important role in clinical routine. Future developments will include the progress of robotic surgery, standardized surgical training and the implementation of novel technologies such as machine learning and artificial intelligence.

For this Special Issue, we invite manuscripts addressing:

  • Robotic surgery;
  • Surgical training;
  • Minimally invasive techniques;
  • Complication management;
  • Machine learning and artificial intelligence;
  • Future and novels strategies;
  • Quality improvement.

In regard to these important aspects and perspectives, Journal of Clinical Medicine provides a Special Issue on current clinical issues and future aspects of the diagnosis and treatment of upper gastrointestinal tract cancer. We welcome high-quality research including original studies, meta-analyses and reviews.

Dr. Christian Denecke
Prof. Dr. Matthias Biebl
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • complication management
  • surgical techniques
  • training
  • future technologies
  • robotic surgery
  • artificial intelligence

Published Papers (2 papers)

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Jump to: Research

Current Issues and Future Technologies in Esophageal Cancer Surgery
J. Clin. Med. 2023, 12(1), 209; https://doi.org/10.3390/jcm12010209 - 27 Dec 2022
Viewed by 507
Gastrointestinal surgery has evolved rapidly in recent years, with laparoscopic techniques being implemented as the standard procedure and robotic surgery becoming increasingly important [...] Full article


Jump to: Editorial

The Learning Curve for Hand-Assisted Laparoscopic Total Gastrectomy in Gastric Cancer Patients
J. Clin. Med. 2022, 11(22), 6841; https://doi.org/10.3390/jcm11226841 - 19 Nov 2022
Cited by 1 | Viewed by 1019
(1) Background: Hand-assisted laparoscopic total gastrectomy (LTG) for patients with gastric cancer (GC) has been established as the standard surgical treatment at our center. This study aims to quantify the learning curve for surgeons performing minimally invasive total gastrectomy at a high-volume single [...] Read more.
(1) Background: Hand-assisted laparoscopic total gastrectomy (LTG) for patients with gastric cancer (GC) has been established as the standard surgical treatment at our center. This study aims to quantify the learning curve for surgeons performing minimally invasive total gastrectomy at a high-volume single center. (2) Methods: One hundred and eighteen consecutive patients who underwent minimally invasive total gastrectomy between January 2014 and December 2020 at a single high-volume center were included and reviewed retrospectively. Risk-adjusted cumulative sum analysis (RA-CUSUM) was used to monitor the surgical outcomes for patients with different risks of postoperative mortality using varying-coefficient logistic regression models. Patients were ordered by the sequential number of the procedure performed and divided into two groups according to the degree of surgeon proficiency as determined by RA-CUSUM analysis (group A: 45; group B: 73 patients). Age, gender, body mass index (BMI), tumor location, pathology, and comorbidities were compared while primary endpoints comprised surgical parameters, postoperative course, and survival outcomes. (3) Results: Forty-four cases were required for the completion of the learning curve. During this time, the mean operating time decreased. Hand-assisted laparoscopic total gastrectomy performed after a learning curve was associated with a shorter median operating time (OT) (360 min vs. 289 min, <0.001), and a reduced length of stay (A = 18.0 vs. B = 14.0 days) (p = 0.154), while there was a trend toward less major complications (Clavien–Dindo (CD) 3–5 within 90 days (12 (26.67%) vs. 10 (13.70%) p = 0.079). Our results showed no difference in anastomotic leakage between the two groups (group A vs. group B, 3 (6.67%) vs. 4 (5.48%) p = 0.99). Similarly, 30-day (0 (0%) vs. 1 (1.7%), p = 0.365) and 90-day mortality (1 (2.08%) vs. 2 (3.39%), p = 0.684) were comparable. Following multivariate analysis, the level of surgical proficiency was not a significant prognostic factor for overall survival. (4) Conclusions: A minimum of 44 cases are required for experienced laparoscopic surgeons to achieve technical competence for performing LTG. While operation time decreased after completion of the learning curve, quality criteria such as achievement of R0 resection, anastomotic leakage, and perioperative mortality remained unaltered. Of note, the level of surgical training showed no significant impact on the 2 year OS or DFS. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

  • The Challenge of Achieving Textbook Outcome after laparoscopic total Gastrectomy for Gastric Cancer
  • The Learning Curve for Ivor Lewis Minimally Invasive Esophagectomy – a single high volume centre experience
  • The Association between Tumor Response and Perioperative Outcome after Neoadjuvant Chemotherapy in Patients with Gastroesophageal Adenocarcinoma.
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