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Recent Advances and Challenges of Surgical Treatment for Pancreatic Disease:...
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Special Issue "Recent Advances and Challenges of Surgical Treatment for Pancreatic Disease: Expert Views"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 746

Special Issue Editor

Dr. Xubao Liu

E-Mail Website
Guest Editor
Department of Pancreatic Surgery, West China School of Medicine/West China Hospital of Sichuan University, Chengdu 332001, China
Interests: pancreas surgery; pancreas cancer; chronic pancreatitis

Special Issue Information

Dear Colleagues,

Pancreatic surgery remains one of the most challenging surgeries because of its high morbidity and mortality. New technologies, such as minimally invasive surgery and organ preservation surgery, are becoming more frequently used.

In this Special Issue of the Journal of Clinical Medicine, we aim to cover recent advances in pancreatic surgery in different diseases, such as pancreas cancer, cystic tumor of the pancreas, pancreatic neuroendocrine tumor, and chronic pancreatitis.

Moreover, the latest developments, including translational research in the treatment of pancreatic cancer, will be addressed.

Dr. Xubao Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgical technique
  • pancreas surgery
  • pancreas cancer
  • cystic tumor of the pancreas
  • pancreatic neuroendocrine tumor
  • chronic pancreatitis
  • neoadjuvant and adjuvant treatment
  • translational research to improve survival

Published Papers (1 paper)

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Research

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Article
Elevated Bile Acid Is Associated with Worsened Impaired Glucose Homeostasis in Pancreatic Ductal Adenocarcinoma Patients with Extrahepatic Cholestasis through Increased Hepatic Insulin Clearance
by
Jie Yang
,
Chunlu Tan
,
Zhenjiang Zheng
,
Xing Wang
,
Xubao Liu
and
Yonghua Chen
J. Clin. Med. 2023, 12(6), 2352; https://doi.org/10.3390/jcm12062352 - 17 Mar 2023
Viewed by 628
Abstract
Background: Patients after pancreaticoduodenectomy (PD) showed improved glucose tolerance. Evidence for the effect of extrahepatic cholestasis on impaired glucose homeostasis secondary to ductal adenocarcinoma of the pancreatic head is limited. Methods: In this prospective cross-sectional study, 50 patients with ductal adenocarcinoma of the [...] Read more.
Background: Patients after pancreaticoduodenectomy (PD) showed improved glucose tolerance. Evidence for the effect of extrahepatic cholestasis on impaired glucose homeostasis secondary to ductal adenocarcinoma of the pancreatic head is limited. Methods: In this prospective cross-sectional study, 50 patients with ductal adenocarcinoma of the pancreatic head were included to assess the effect of extrahepatic cholestasis on glucose tolerance status based on the oral glucose tolerance test (OGTT) before pancreatic surgery. Results: Patients with extrahepatic cholestasis more frequently suffered from worsened impaired glucose homeostasis (prediabetes and new-onset diabetes, 95.2% vs. 58.6%, p = 0.004). Elevated bile acid level was recognized as an independent risk factor for impaired glucose homeostasis (p = 0.024, OR = 6.85). Hepatic insulin clearance (HIC) was significantly higher in patients with elevated bile acid levels (p = 0.001). A strong positive correlation was found between bile acid levels and HIC (r = 0.45, p = 0.001). Conclusions: This study suggested a connection between elevated bile acid levels and worsened impaired glucose homeostasis through increased insulin clearance function in ductal adenocarcinoma of pancreatic head patients. Full article
(This article belongs to the Special Issue Recent Advances and Challenges of Surgical Treatment for Pancreatic Disease: Expert Views)
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