Targeted Therapies and Clinical Outcomes for Ischemic Stroke

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1777

Special Issue Editor

Dr. Farhan Siddiq
E-Mail Website
Guest Editor
Division of Neurosurgery, University of Missouri, Columbia, MO 65211, USA
Interests: ischemic stroke; cerebral bleed; cerebrovascular disease; vascular stroke; neurological surgery

Special Issue Information

Dear Colleagues,

Our Special Issue on "Targeted Therapies and Clinical Outcomes for Ischemic Stroke" aims to provide a comprehensive overview of the latest advancements in targeted therapy research. The collection of articles in this Special Issue will focus on areas such as stroke pathogenesis, biomarkers for diagnosis and prognosis purposes, imaging technologies, as well as the development of new drugs and therapeutic approaches for ischemic stroke.

We are seeking original research articles, reviews, and perspectives that showcase innovative techniques and strategies related to the prevention and treatment of ischemic stroke. However, please note that we will not accept mini-reviews or case reports in this Special Issue.

Overall, this Special Issue provides an excellent opportunity for researchers, clinicians, and scholars to present their findings and share their insights on the latest developments in targeted therapy for ischemic stroke. We believe that this Special Issue will play a vital role in promoting progress in this field, and we look forward to receiving contributions from experts around the globe.

Dr. Farhan Siddiq
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic stroke
  • neuroprotection
  • thrombectomy
  • clinical trials
  • endovascular treatment
  • neuroimaging
  • rehabilitation

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

25 pages, 1138 KiB  
Review
Targeted Temperature Management for Patients with Acute Ischemic Stroke: A Literature Review
J. Clin. Med. 2024, 13(2), 586; https://doi.org/10.3390/jcm13020586 - 19 Jan 2024
Viewed by 1462
Abstract
Despite significant advances in medical imaging, thrombolytic therapy, and mechanical thrombectomy, acute ischemic strokes (AIS) remain a major cause of mortality and morbidity globally. Targeted temperature management (TTM) has emerged as a potential therapeutic intervention, aiming to mitigate neuronal damage and improve outcomes. [...] Read more.
Despite significant advances in medical imaging, thrombolytic therapy, and mechanical thrombectomy, acute ischemic strokes (AIS) remain a major cause of mortality and morbidity globally. Targeted temperature management (TTM) has emerged as a potential therapeutic intervention, aiming to mitigate neuronal damage and improve outcomes. This literature review examines the efficacy and challenges of TTM in the context of an AIS. A comprehensive literature search was conducted using databases such as PubMed, Cochrane, Web of Science, and Google Scholar. Studies were selected based on relevance and quality. We identified key factors influencing the effectiveness of TTM such as its timing, depth and duration, and method of application. The review also highlighted challenges associated with TTM, including increased pneumonia rates. The target temperature range was typically between 32 and 36 °C, with the duration of cooling from 24 to 72 h. Early initiation of TTM was associated with better outcomes, with optimal results observed when TTM was started within the first 6 h post-stroke. Emerging evidence indicates that TTM shows considerable potential as an adjunctive treatment for AIS when implemented promptly and with precision, thereby potentially mitigating neuronal damage and enhancing overall patient outcomes. However, its application is complex and requires the careful consideration of various factors. Full article
(This article belongs to the Special Issue Targeted Therapies and Clinical Outcomes for Ischemic Stroke)
Show Figures

Figure 1

Back to TopTop