Updates on the Management of Peripheral Arterial Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Vascular Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1222

Special Issue Editor


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Guest Editor
Interventional Cardiology Service, "Montevergine" Clinic, GVM Care & Research, 83013 Mercogliano, Italy
Interests: interventional cardiology; transcatheter aortic valve replacement; coronary artery disease; peripheral disease; carotid disease; aortic disease

Special Issue Information

Dear Colleagues,

Peripheral artery disease (PAD), ranging from intermittent claudication to critical limb-threatening ischemia, affects more than 200 million people worldwide, with a huge increase in prevalence in the last decade. Over the years, different pharmacological and interventional strategies have been recommended. Medical management includes smoking cessation, exercise programs, lipid-lowering, and antiplatelet therapies, while interventional strategies include surgical and endovascular revascularization.

Endovascular revascularization has progressively gained the role of a primary treatment strategy thanks to recent technological advances. However, the presence of vascular calcification may still affect the efficacy of endovascular therapies. Therefore, new techniques for vessel preparation have been developed aiming to improve short- and long-term outcomes.

The aim of the present Special Issue is to provide a comprehensive update on the diagnosis and treatment of patients with PAD, covering several aspects, from procedural techniques to medical management. Therefore, we invite interventional cardiologists and clinicians to submit their works related to this particular field.

Thank you,

Dr. Angelo Cioppa
Guest Editor

Manuscript Submission Information

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Keywords

  • peripheral artery disease (PAD)
  • percutaneous transluminal angioplasty (PTA)
  • claudicatio intermittens
  • critical limb ischemia
  • lipid-lowering therapy
  • antiplatelet therapy

Published Papers (1 paper)

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Review

12 pages, 1389 KiB  
Review
Peripheral Arterial Disease and the Diabetic Foot Syndrome: Neuropathy Makes the Difference! A Narrative Review
by Gerhard Rümenapf, Nour Abilmona, Stephan Morbach and Martin Sigl
J. Clin. Med. 2024, 13(7), 2141; https://doi.org/10.3390/jcm13072141 - 8 Apr 2024
Viewed by 1065
Abstract
Background: In vascular medicine, peripheral arterial disease (PAD) and diabetic foot syndrome (DFS) are often considered synonymous with respect to the need for revascularization. In PAD patients, clinical symptoms reflect the degree of atherosclerotic disease, since peripheral innervation, including pain sensation, is [...] Read more.
Background: In vascular medicine, peripheral arterial disease (PAD) and diabetic foot syndrome (DFS) are often considered synonymous with respect to the need for revascularization. In PAD patients, clinical symptoms reflect the degree of atherosclerotic disease, since peripheral innervation, including pain sensation, is not usually compromised. In DFS patients, however, symptoms of relevant foot ischemia are often absent and progression of ischemia goes unnoticed owing to diabetic polyneuropathy, the loss of nociception being the main trigger for foot ulcers. This review analyzes the fundamental differences between PAD and DFS against the background of polyneuropathy. Methods: The literature research for the 2014 revision of the German evidence-based S3-PAD-guidelines was extended to 2023. Results: Vascular examination is imperative for both, PAD and DFS. Stage-dependent revascularization is of utmost importance in PAD patients, especially those suffering from critical limb-threatening ischemia (CLTI). Successful therapy of DFS goes further, including infection and metabolic control, wound management, offloading the foot and lifelong prophylaxis in the course of a multidisciplinary treatment concept. Revascularization is not needed in all cases of DFS. Conclusions: There are fundamental differences between PAD and DFS with respect to pathophysiology, the anatomical distribution of arterial occlusive processes, the clinical symptoms, the value of diagnostic tools such as the ankle-brachial index, and classification. Also, therapeutic concepts differ substantially between the two patient populations. Full article
(This article belongs to the Special Issue Updates on the Management of Peripheral Arterial Disease)
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