Clinical Trajectory of Anorexia Nervosa from Endophenotypes to Prognostic Factors

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 652

Special Issue Editors

1. Fondation Santé des Etudiants de France, University Center for Adolescent and Young Adult Health, 75014 Paris, France
2. CESP, INSERM, UMR 1018, University Paris-Sud, 94800 Villejuif, France
3. Simone Veil Faculty of Medicine, UVSQ, Paris-Saclay University, 78690 Saint-Quentin en Yvelines, France
Interests: anorexia nervosa
Special Issues, Collections and Topics in MDPI journals
Dr. Corinne Blanchet-Collet
E-Mail Website
Guest Editor
1. Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Maison de Solenn-Maison des Adolescents, 75014 Paris, France
2. Inserm U1018, Team DevPsy, CESP, Paris Saclay University, Paris, France
3. PCPP, Paris Cité University, 92100 Boulogne-Billancourt, France
Interests: anorexia nervosa; eating disorders; adolescent development; human nutrition; clinical endocrinology

Special Issue Information

Dear Colleagues,

Anorexia nervosa is a complex and multifactorial condition with a lifetime prevalence of 1.4% for women and 0.2% for men, with a high risk of chronicity into adulthood. The phenotypic expression of AN is heterogeneous and highly unstable over time, with more than 50% diagnostic cross-over and migration between other eating disorders categories. Long-term prognosis and global outcome are not easily predictable, and biomarkers as predictive factors are seriously lacking. The concept of phenotype was introduced in psychiatry in the 1970s, and more recently, the concept of endophenotype linking genetic vulnerability and/or environment to disease occurrence was also introduced. Various endo- or sub-phenotypes crossing category boundaries have been suggested for eating disorders, but serious scientific evidence for candidate biomarkers is still under debate. To date, endophenotype research in anorexia nervosa has massively focused on neurocognitive factors. The identification of intermediate phenotypes would have major implications in terms of care objectives and therapeutic strategies.

The aim of this Special Issue is to provide an overview of multiple clinical trajectories of anorexia nervosa, to highlight potential patient endophenotypes or sub-phenotypes, and to study the evolution of patients according to their phenotype. The latter could be neuropsychiatric biomarkers but also biological, endocrine, anthropometric, or any trait/state vulnerability markers allowing to describe phenotypes with different clinical evolutions beyond the similar initial symptoms leading to the diagnosis of anorexia nervosa.

Therefore, we welcome the submission of original research papers dealing with the topics of diagnostic and therapeutic advances in patients with anorexia nervosa.

Dr. Chantal Stheneur
Dr. Corinne Blanchet-Collet
Guest Editors

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  • anorexia nervosa
  • eating disorders
  • nutrition
  • global outcome
  • long-term prognosis
  • clinical trajectory

Published Papers (1 paper)

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13 pages, 491 KiB  
Recovery Trajectories in Adolescent Girls with Anorexia Nervosa
J. Clin. Med. 2024, 13(3), 778; - 29 Jan 2024
Viewed by 461
Background: This study aimed to document recovery trajectories among adolescents with anorexia nervosa (AN) based on three markers of remission, namely changes in body weight, food restriction, and excessive exercise, and to identify predictors of these trajectories. Methods: One hundred twenty-six adolescent girls [...] Read more.
Background: This study aimed to document recovery trajectories among adolescents with anorexia nervosa (AN) based on three markers of remission, namely changes in body weight, food restriction, and excessive exercise, and to identify predictors of these trajectories. Methods: One hundred twenty-six adolescent girls (14.7 ± 1.3 years) were recruited during initial assessment visits at specialized eating disorder (ED) programs in five University Health Centers across the province of Quebec, Canada. z-BMI and AN symptom severity (food restriction and excessive exercise) were assessed at initial assessment visits and subsequently reassessed at each quarterly follow-up over a 12-month period to identify recovery trajectories. Results: Considering the three markers of remission, three distinct trajectories emerged: Group 1, rapid responders; Group 2, gradual responders; and Group 3, unstable responders. At initial visits, a difference between groups was found regarding the type of treatment (p = 0.01) and weight suppression (p = 0.02). Group 1 had a higher number of youths hospitalized than Group 2 and Group 3, and a greater weight suppression than Group 3. Furthermore, individuals with atypical AN were more likely to belong to Group 2 than to Group 1 and Group 3 (p < 0.0001). Conclusions: This study contributes to a better understanding of the heterogeneity of recovery trajectories in adolescent girls with AN. Full article
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