Gender Dysphoria: Current Approach to Clinical Care and Research

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 195

Special Issue Editors

E-Mail Website
Guest Editor
Section of Endocrinology, University of Palermo, 90127 Palermo, Italy
Interests: sex hormones; gender dysphoria; hypogonadism; metabolism; growth hormone; puberty disorders

Special Issue Information

Dear Colleagues,

Gender dysphoria can be described as a condition of discomfort and persistent suffering caused by feeling one's gender identity is different from one's biological sex. Subjects with gender dysphoria present a marked inconsistency between the gender attributed to them at the time of birth (generally, reference is made to phenotypic sex) and the gender they experience/express. Gender identity disorder causes discomfort toward one's own body, perceived as distant and alien. Although not all subjects may suffer from this inconsistency, the majority suffer from it because they are unable to implement the physical interventions required for hormonal and sometimes even surgical treatment.

Individuals with this condition have the opportunity to receive psychological support and medical assistance, in order to start a process that will lead to a change in their personal and/or anatomical sex. Among the various interventions, in order to modify their secondary sexual characteristics so that they align with their gender identity, hormone replacement therapy for trans people consists of taking hormones (feminizing such as estrogen or masculinizing such as testosterone). Scientific interest in better characterizing and assisting the hormonal transition process of trans people has recently increased, both from a psychological and general health point of view. The distress caused by gender dysphoria is typically described as a combination of anxiety, depression, irritability, self-harm, suicidal ideation (up to 60% of cases), eating disorders (mainly caused by the attempt to control the development of one's body and to limit the typical changes in a greater bodily "sexual characterization"), substance abuse and a pervasive sense of not feeling comfortable in one's own body. Some subjects present internalized transphobia (negative feelings toward their condition), often presenting poor acceptance, low self-esteem, feelings of inferiority and guilt, shame and identification with denigrating stereotypes. Individuals who have experienced harassment and violence may later experience post-traumatic stress disorder. Therefore, in many cases, long-term psychotherapeutic assistance is necessary. This condition is therefore of considerable interest because it involves many clinical areas, both in diagnosis and in hormonal, surgical, psychological and psychiatric treatment. This Special Issue aims to collate research articles and reviews regarding the clinical diagnosis, monitoring and treatment of gender dysphoria.

Prof. Dr. Michele Roccella
Dr. Stefano Radellini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gender identity
  • childhood
  • gender dysphoria
  • persistence
  • psychosexual development
  • treatment
  • autism spectrum disorder
  • co-morbidity
  • co-occurrence
  • gender identity disorder
  • adolescents
  • cross-hormone treatment
  • rapid-onset gender dysphoria
  • sex ratio
  • suicidality

Published Papers

This special issue is now open for submission.
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