Updates in Liver Cirrhosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 28 April 2024 | Viewed by 3359

Special Issue Editors


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Guest Editor
1. Department of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
2. Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, Iasi, Romania
Interests: non-alcoholic fatty liver disease; liver transplantation; capsule endoscopy; gastrointestinal bleeding; inflammatory bowel disease

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Guest Editor
1. Department of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
2. Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, Iasi, Romania
Interests: acute and chronic liver disease; steatohepatitis; liver transplantation; inflammatory bowel disease; celiac disease; endomicroscopy
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Special Issue Information

Dear Colleagues,

Liver cirrhosis, traditionally defined as the end stage of advanced liver disease, remains a significant health challenge globally, impacting millions of individuals, and posing complex clinical and therapeutic considerations due to its severe complications. Recently, progress in the understanding of and approach to liver cirrhosis has been made, and new concepts such as regression, recompensation or disease modifiers are currently being debated. The optimal management of complication is an equally key issue. In liver transplantation, the present hot topics include extended criteria donors, organ preservation, precision medicine, and biomarkers for rejection. Also, appropriate palliative care in end-stage liver disease is of tremendous importance in terms of duration but especially the quality of a patient’s life.

We are pleased to announce and extend an invitation to submit manuscripts for a Special Issue of Journal of Clinical Medicine focused on “Updates in Liver Cirrhosis”. The goal of this Special Issue is to provide a comprehensive platform for researchers, clinicians, and experts in the field to share their latest findings, insights, and advancements related to liver cirrhosis. We welcome original research articles and reviews that contribute to the enhancement of knowledge in this critical area.

Topics of interest for this Special Issue include, but are not limited to:

  • Etiology and Pathogenesis of Liver Cirrhosis;
  • Diagnostic Innovations and Biomarkers;
  • Advances in Imaging Techniques for Cirrhosis Assessment;
  • Novel therapeutic Approaches and Drug Development;
  • Complications of Cirrhosis: Prevention and Management;
  • Liver Transplantation;
  • Multidisciplinary Approaches to Cirrhosis Care;
  • Quality of Life Enhancement.

Dr. Ana-Maria Singeap
Prof. Dr. Anca Trifan
Guest Editors

Manuscript Submission Information

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Keywords

  • hepatic fibrosis
  • portal hypertension
  • disease modifiers
  • cirrhosis complications
  • acute-on-chronic liver failure
  • hepatocellular carcinoma
  • liver transplantation
  • quality of life

Published Papers (3 papers)

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Research

14 pages, 2749 KiB  
Article
Human Neutrophil Alpha-Defensins Promote NETosis and Liver Injury in Alcohol-Related Liver Cirrhosis: Potential Therapeutic Agents
by Anna Rycyk-Bojarzyńska, Beata Kasztelan-Szczerbińska, Halina Cichoż-Lach, Agata Surdacka and Jacek Roliński
J. Clin. Med. 2024, 13(5), 1237; https://doi.org/10.3390/jcm13051237 - 22 Feb 2024
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Abstract
Background: Neutrophils are thought to play a pivotal role in the pathogenesis of many inflammatory diseases, such as hepatitis, liver cirrhosis, etc. Activated human neutrophils release human neutrophil peptides (HNP1-3) or alpha-defensins that are antimicrobial peptides in azurophil granules. Furthermore, HNP1-3 build [...] Read more.
Background: Neutrophils are thought to play a pivotal role in the pathogenesis of many inflammatory diseases, such as hepatitis, liver cirrhosis, etc. Activated human neutrophils release human neutrophil peptides (HNP1-3) or alpha-defensins that are antimicrobial peptides in azurophil granules. Furthermore, HNP1-3 build a scaffold of neutrophil extracellular traps (NETs) and promote the process of programmed cell death called NETosis. Our study aimed to investigate the role of alpha-defensins in the pathogenesis of alcohol-related liver cirrhosis (ALC). Methods: The concentrations of alpha-defensins in the plasma of 62 patients with ALC and 24 healthy subjects were measured by ELISA. The patients with ALC were prospectively recruited based on the severity of liver dysfunction according to the Child-Pugh and Model of End-Stage Liver Disease-Natrium (MELD-Na) scores, modified Maddrey’s Discriminant Function (mDF), and the presence of ALC complications. Results: The concentrations of alpha-defensins in plasma were significantly higher in the ALC patients than in the controls. The plasma levels of HNP1-3 correlated with the MELD and mDF scores. ALC subgroups with MELD > 20 and mDF > 32 displayed significantly higher HNP1-3 concentrations. The plasma levels of HNP1-3 revealed a good predictive AUC for hepatic encephalopathy and ascites development (0.81 and 0.74, respectively) and for patient survival (0.87) in those over 40 years of age. Conclusion: These findings suggest that alpha-defensins play an important role in the assessment of ALC. Full article
(This article belongs to the Special Issue Updates in Liver Cirrhosis)
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11 pages, 1296 KiB  
Article
The Impact of Alcohol Consumption Pattern on Liver Fibrosis in Asymptomatic Patients
by Horia Minea, Ana-Maria Singeap, Catalin Victor Sfarti, Irina Girleanu, Stefan Chiriac, Cristina Muzica, Tudor Cuciureanu, Oana Cristina Petrea, Laura Huiban, Sebastian Zenovia, Robert Nastasa, Adrian Rotaru, Remus Stafie, Ermina Stratina, Camelia Cojocariu, Carol Stanciu and Anca Trifan
J. Clin. Med. 2023, 12(23), 7405; https://doi.org/10.3390/jcm12237405 - 29 Nov 2023
Cited by 1 | Viewed by 734
Abstract
Introduction: Alcohol consumption (AC) represents a widespread cause of liver diseases affecting 10–20% of the population. The study aimed to evaluate the relationship between advanced liver fibrosis (ALF) measured by transient elastography (TE), laboratory parameters, and the amount of AC depending on non-modifiable [...] Read more.
Introduction: Alcohol consumption (AC) represents a widespread cause of liver diseases affecting 10–20% of the population. The study aimed to evaluate the relationship between advanced liver fibrosis (ALF) measured by transient elastography (TE), laboratory parameters, and the amount of AC depending on non-modifiable risk factors such as age and gender. Methods: We examined 689 patients with an average age of 49.32 ± 14.31 years, 72.9% males, without liver pathology, who admitted a moderate/high consumption (female ≤ 7 versus > 7 drinks/week; male ≤ 14 versus > 14 drinks/week) for at least five years. The fibrosis level was adjusted according to transaminase levels. Predictive factors were established using univariate regression analysis. Results: ALF (≥F3) was detected in 19.30% of subjects, predominantly males (14.1%) and patients over 55 years (12.5%). Excessive consumption of distilled spirits is associated with ALF in females (OR = 4.5), males (OR = 6.43) and patients over 55 years (OR = 3.73). A particularity highlighted in both genders, regardless of the age group, was the negative correlation between the decrease in the number of platelets, the albumin concentration, and the appearance of AFL. Conclusions: Screening using TE represents an approach for early detection of ALF in asymptomatic populations and the development of a risk stratification scheme. Full article
(This article belongs to the Special Issue Updates in Liver Cirrhosis)
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22 pages, 8196 KiB  
Article
Nutrition and Mental Well-Being: Exploring Connections and Holistic Approaches
by Theodora Claudia Gheonea, Carmen-Nicoleta Oancea, Magdalena Mititelu, Elena Carmen Lupu, Corina-Bianca Ioniță-Mîndrican and Ion Rogoveanu
J. Clin. Med. 2023, 12(22), 7180; https://doi.org/10.3390/jcm12227180 - 20 Nov 2023
Cited by 1 | Viewed by 1610
Abstract
Quality of life, well-being, and psycho-emotional balance are closely related to the quality of the diet, the level of physical activity, the quality of rest, but also the absence of the consumption of narcotic substances and tobacco, or alcohol abuse. Based on the [...] Read more.
Quality of life, well-being, and psycho-emotional balance are closely related to the quality of the diet, the level of physical activity, the quality of rest, but also the absence of the consumption of narcotic substances and tobacco, or alcohol abuse. Based on the distribution of a questionnaire that included 30 questions, we aimed to statistically evaluate several factors that influence mental health and vices. It recorded a total of 1719 valid responses, which came from 78.3% female respondents and 21.7% male respondents. After processing the anthropometric data, it was observed that the majority of respondents are of normal weight (63.87%) and come from women in particular (36.13%). Based on the answers recorded, although over 60% of the respondents participating in the study are up to 40 years old, there is an increased tendency towards sedentarism (over 58% of the respondents declaring that they do sports very rarely or not at all), a low tendency regarding optimal consumption of vegetables and fruits, many respondents do not hydrate properly, which is why approximately 60% of respondents feel frequently tired, and over 32% are frequently nervous. The increased level of stress among the respondents and emotional eating are also generated by inadequate rest, reduced physical activity, and a diet that does not help the efficient detoxification of the body. Full article
(This article belongs to the Special Issue Updates in Liver Cirrhosis)
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