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Liver Resection: Latest Advances and Prospects
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Liver Resection: Latest Advances and Prospects

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 4392

Special Issue Editors

Prof. Dr. Yilei Mao

E-Mail Website
Guest Editor
Department of Liver Surgery, Peking Union Medical College Hospital, Beijing, China
Interests: gallbladder cancer; hepatocellular carcinoma; immunotherapy; surgical treatment
Dr. Haifeng Xu

E-Mail Website
Guest Editor
Department of Liver Surgery, Peking Union Medical College Hospital, Beijing, China
Interests: hepatectomy; laparoscopic surgery; surgical resection; liver surgery

Special Issue Information

Dear Colleagues,

Hepatectomy has been applied in the surgical clinic routinely for years to treat benign and malignant liver lesions. It is also seen as a possible curative treatment for liver cancers. With a better understanding of the liver anatomy, improvements in surgical techniques and instruments, and progress in the concept of perioperative care, hepatectomy has become more and more safe and effective for liver cancers. In recent years, great progress has been made in the following fields: liver resection in an anatomically difficult location, minimal invasive surgeries such as laparoscopic and robotic hepatectomy, two-stage hepatectomies such as ALPPS, and fine preoperative evaluation of liver function and risks of surgery. It is time to summarize and comments on the progress of these improvements. We thus tried to organize a Special Issue focusing on the above aspects.

Prof. Dr. Yilei Mao
Dr. Haifeng Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatectomy
  • liver anatomy
  • liver cancers
  • hepatocellular carcinoma

Published Papers (4 papers)

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Editorial

Jump to: Research, Review, Other

3 pages, 191 KiB  
Editorial
Minimally Invasive Hepatectomy for Liver Tumors: Where Are We Now?
by Kelvin K. C. Ng
J. Clin. Med. 2023, 12(14), 4583; https://doi.org/10.3390/jcm12144583 - 10 Jul 2023
Viewed by 532
Abstract
With advancements in minimally invasive (MIS) technology and techniques, MIS hepatectomy has evolved as an effective treatment for both benign and malignant liver tumors [...] Full article
(This article belongs to the Special Issue Liver Resection: Latest Advances and Prospects)

Research

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12 pages, 1391 KiB  
Article
A Nomogram Based on Preoperative Lab Tests, BMI, ICG-R15, and EHBF for the Prediction of Post-Hepatectomy Liver Failure in Patients with Hepatocellular Carcinoma
by Deyao Zhang, Yangxun Pan, Zhenyun Yang, Huilan Zeng, Xin Wang, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Minshan Chen and Dandan Hu
J. Clin. Med. 2023, 12(1), 324; https://doi.org/10.3390/jcm12010324 - 31 Dec 2022
Cited by 2 | Viewed by 1407
Abstract
Background: Liver cancer is one of the most common malignant tumors, and worldwide, its incidence ranks sixth, and its morality third. Post-hepatectomy liver failure (PHLF) is the leading cause of death in patients who have undergone liver resection. This retrospective study investigated the [...] Read more.
Background: Liver cancer is one of the most common malignant tumors, and worldwide, its incidence ranks sixth, and its morality third. Post-hepatectomy liver failure (PHLF) is the leading cause of death in patients who have undergone liver resection. This retrospective study investigated the risk factors for PHLF by predicting and constructing an index to evaluate the risk. This was achieved by combining the lab tests with an indocyanine green (ICG) clearance test. Methods: The study analyzed 1081 hepatocellular carcinoma (HCC) patients who had received liver resection at Sun Yat-sen University Cancer Center between 2005 and 2020. The patients were divided into a PHLF group (n = 113) and a non-PHLF group (n = 968), according to the International Study Group of Liver Surgery (ISGLS) criteria. Receiver operating characteristics (ROC) curves were then used to estimate the optimal cut-off values. Univariate and multivariate logistic regression analyses were performed to identify the independent risk factors. Finally, a nomogram was constructed where the calibration plot, the areas under the ROC curve (AUC), and the decision curve analysis (DCA) showed good predictive ability. Results: Correlation analysis revealed that body mass index (BMI) was positively correlated with ICG-R15 and with effective hepatic blood flow (EHBF). Univariate and multivariate logistics regression analysis revealed that BMI, ICG-R15, international normalized ratio (INR), tumor size, hepatic inflow occlusion (HIO) time, and operation method were independent predictive factors for PHLF. When these factors and EHBF were included in the nomogram, the nomogram showed a good predictive value, with a C-index of 0.773 (95% Confidence Interval [CI]: 0.729–0.818). The INR had the largest ROC areas (AUC INR = 0.661). Among the variables, ICG-R15 (AUC ICG-R15 = 0.604) and EHBF (AUC EHBF = 0.609) also showed good predictive power. Conclusions: The risk of PHLF in HCC patients can be precisely predicted by this model prior to the operation. By integrating EHBF into the model, HCC patients at higher risk for PHLF can be identified more effectively. Full article
(This article belongs to the Special Issue Liver Resection: Latest Advances and Prospects)
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Review

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12 pages, 273 KiB  
Review
From Conversion to Resection for Unresectable Hepatocellular Carcinoma: A Review of the Latest Strategies
by Chen Liang, Zhaoqian He, Qiang Tao, Xiang Tang, Lingmin Jiang, Xinyue Tu, Zonghao Liu, Hua Chen, Feihu Xie and Yun Zheng
J. Clin. Med. 2023, 12(24), 7665; https://doi.org/10.3390/jcm12247665 - 13 Dec 2023
Viewed by 778
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, accounting for the majority of primary liver cancer cases. Liver resection is the preferred curative method for early-stage HCC. However, up to 80–85% of patients have already missed the opportunity [...] Read more.
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, accounting for the majority of primary liver cancer cases. Liver resection is the preferred curative method for early-stage HCC. However, up to 80–85% of patients have already missed the opportunity of radical surgery due to tumor advances at the time of consultation. Conversion therapies are a series of medications and treatments for initially inoperable patients. For early-stage unresectable HCC (uHCC) patients, conversion therapies are designed to meet surgical requirements by increasing the volume of the residual liver. Meanwhile, for advanced cases, conversion therapies strive for tumor shrinkage and down-staging, creating the opportunity for liver resection or liver transplantation. This review summarizes the latest advances in conversion therapies and highlights their potential for improving the survival benefit of patients with uHCC. Full article
(This article belongs to the Special Issue Liver Resection: Latest Advances and Prospects)

Other

9 pages, 585 KiB  
Systematic Review
Trends in Minimally Invasive Approaches for Liver Resections–A Systematic Review
by Florin Graur, Razvan Alexandru Ciocan, Andra Ciocan, Ion Cosmin Puia, Emil Mois, Luminita Furcea, Florin Zaharie, Calin Popa, Diana Schlanger, Calin Vaida, Doina Pisla and Nadim Al Hajjar
J. Clin. Med. 2022, 11(22), 6721; https://doi.org/10.3390/jcm11226721 - 14 Nov 2022
Cited by 1 | Viewed by 1233
Abstract
Background: SILS (single incision laparoscopic surgery) and NOTES (natural orifice transluminal endoscopic surgery) are considered breakthroughs in minimally invasive surgery, the first consisting in the surgeon working via a single entrance site and the second via a natural orifice (e.g., oral cavity). Methods: [...] Read more.
Background: SILS (single incision laparoscopic surgery) and NOTES (natural orifice transluminal endoscopic surgery) are considered breakthroughs in minimally invasive surgery, the first consisting in the surgeon working via a single entrance site and the second via a natural orifice (e.g., oral cavity). Methods: Since 2000 until 2022, the original articles published in the online databases were analyzed. Eligible studies included information about the current therapy of patients with liver surgical pathology and how the two new techniques improve the surgical approach. Results: A total of 798 studies were identified. By applying the exclusion criteria, nine studies remained to be included in the review. Two out of nine studies examined the NOTES approach in liver surgery, whereas the other seven focused on the SILS technique. The age of the patients ranged between 24 and 83 years. Liver resections for hepatocellular carcinoma or colorectal metastases were undertaken and biliary or hydatid cysts were removed. The mean procedure time was 95 to 205 min and the average diameter of the lesions was 5 cm. Conclusions: When practiced by multidisciplinary teams, transvaginal liver resection is feasible and safe. The goals of SILS and NOTES are to be less intrusive, more easily tolerated and aesthetic. Full article
(This article belongs to the Special Issue Liver Resection: Latest Advances and Prospects)
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