Special Issue "New Update on the Diagnosis and Treatment of Hepatobiliary Cancer"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 1753

Special Issue Editors

Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
Interests: hepatobiliary cancer; immune checkpoint inhibitors; surgery; translational research
Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China
Interests: hepatobiliary cancer; immune checkpoint inhibitors; surgery; translational research
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Special Issue Information

Dear Colleagues,

Hepatobiliary cancer is a malignant tumor with a high mortality rate among the affected patients. The aggressive behavior of the disease and the typically advanced stage of the disease at the time of diagnosis are the main causes of this high mortality rate. However, in recent years, several advances have been made in the management of this family of diseases. The improvement of surgical techniques, targeted chemotherapy, radiotherapy, immune checkpoint inhibitor therapy, and radiological and endoscopic techniques are at the core of research in the hepatobiliary field.

We invite authors to share their knowledge, perspectives, and recent advances in the management of hepatobiliary malignancies through this Special Issue of the Journal of Clinical Medicine.

Prof. Dr. Weixing Wang
Dr. Jun He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver cancer
  • biliary tract cancer
  • diagnosis
  • treatment
  • surgery
  • immune checkpoint inhibitors
  • translational research

Published Papers (1 paper)

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Research

14 pages, 7237 KiB  
Article
Uridine Inhibits Hepatocellular Carcinoma Cell Development by Inducing Ferroptosis
J. Clin. Med. 2023, 12(10), 3552; https://doi.org/10.3390/jcm12103552 - 18 May 2023
Cited by 1 | Viewed by 1335
Abstract
Uridine is a key metabolite used as a substrate for the production of DNA, RNA, and glucose, and it is mainly synthesized in the liver. Currently, it is not known whether uridine levels are altered in the tumor microenvironment of patients with hepatocellular [...] Read more.
Uridine is a key metabolite used as a substrate for the production of DNA, RNA, and glucose, and it is mainly synthesized in the liver. Currently, it is not known whether uridine levels are altered in the tumor microenvironment of patients with hepatocellular carcinoma (HCC) and whether uridine can be a target for tumor therapy. In this study, the detection of genes associated with de novo uridine synthesis, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD) (n = 115), and dihydroorotate dehydrogenase (DHODH) (n = 115) in HCC tissues through tissue microarrays revealed that the expression of CAD and DHODH was higher in tumor compared with paraneoplastic tissues. Next, we collected tumor tissues from surgically resected HCC patients and the corresponding adjacent non-tumor tissues (n = 46) for LC–MS/MS assays. The results showed that the median and interquartile ranges of uridine content in non-tumor and tumor tissues were 640.36 (504.45–807.43) and 484.22 (311.91–626.73) nmol/g, respectively. These results suggest that uridine metabolism is disturbed in HCC patients. To further investigate whether uridine can be used as a tumor-therapeutic target, a series of high concentrations of uridine were incubated with HCC cells in vitro and in vivo. It was observed that uridine dose-dependently inhibited the proliferation, invasion, and migration of HCC cells by activating the ferroptosis pathway. Overall, these results reveal for the first time the range of uridine content in human HCC tissues and suggest that uridine may be a new target for HCC therapy. Full article
(This article belongs to the Special Issue New Update on the Diagnosis and Treatment of Hepatobiliary Cancer)
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