Clinical Management and Challenges in Vaginal Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 2378

Special Issue Editors

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Guest Editor
Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy
Interests: ovarian cancer; vulvar cancer; endometrial cancer; vaginal cancer; cervical cancer; gynecological oncology; ERAS protocols

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Guest Editor
Department of Gynaecological Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Interests: ultraradical surgery for ovarian cancer; gynecological oncology

Special Issue Information

Dear Colleagues,

Primary vaginal cancer is an uncommon gynecologic malignancy. In view of the rarity of this disease, there is less evidence on standardization of management, whereas a great range of therapeutic options are available. A lot of the data used during treatment are derived from cervical cancer knowledge, where the radiation approach plays a significant role. Despite radiotherapy being able to improve local control, survival, and toxicity, the surgical option should always be evaluated by considering the curative or palliative intent, the age of the patient and the anatomical relations with the surrounding organs. The aim of this Special Issue is to collect case series, original studies, reviews and original case reports regarding the diagnosis and treatment of all types of vaginal cancer.

Dr. Federico Ferrari
Dr. Hooman Soleymani majd
Guest Editors

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  • vaginal cancer
  • radiotherapy
  • surgery
  • rare neoplasm

Published Papers (1 paper)

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11 pages, 2508 KiB  
Diagnosis, Treatment and Prognosis of Mesonephric Adenocarcinoma of the Vagina: A Literature Review and a Case Report
by Federico Ferrari, Andrea Salvatore Omodei, Filippo Alberto Ferrari, Hooman Soleymani Majd, Laura Ardighieri, Salvatore Giovanni Vitale, Antonio Simone Laganà, Stefano Angioni, Giuseppe Ciravolo and Franco Odicino
J. Clin. Med. 2023, 12(14), 4846; - 23 Jul 2023
Cited by 1 | Viewed by 2047
Background: Mesonephric adenocarcinoma (MA) of the vagina is a rare tumor that arises from mesonephric remnants (Wolffian) in the female genital tract. It is a neoplasm with no significant evidence about its diagnosis, treatment, follow-up and prognosis. Methods: Systematic research of the literature [...] Read more.
Background: Mesonephric adenocarcinoma (MA) of the vagina is a rare tumor that arises from mesonephric remnants (Wolffian) in the female genital tract. It is a neoplasm with no significant evidence about its diagnosis, treatment, follow-up and prognosis. Methods: Systematic research of the literature was conducted in Scopus, PubMed/MEDLINE, ScienceDirect and the Cochrane Library, including observational prospective and retrospective studies, case series and case reports. We collected data regarding studies related to diagnosis and treatment options evaluating the following aspects: study design, population, treatment type, rate of surgical complications and fertility outcome. We further included a case report of laparoscopic management of MA with pictorial assays. Results: Thirteen cases of MA of the vagina are available in the literature, including our case report. The median age at diagnosis was 52 years old; the majority of patients reported vaginal bleeding as a symptom (38%); and ultrasound, followed by a magnetic resonance and CT scan were the diagnostic tools most used. In 54% of the cases, a surgical biopsy was performed, and 92% of the patients underwent upfront surgery with an open access or vaginal resection except one case fully managed by minimally invasive surgery. Most of the patients (68%) received adjuvant treatment with chemotherapy or radiotherapy or a combination of them. The mean follow-up period was 6 years. Conclusions: Despite the rarity of this cancer and bizarre location, a minimally invasive approach seems feasible after multidisciplinary evaluation. According to the rarity of this tumor, any future case and follow-up data must be reported in the literature in order to enlarge the knowledge about it. Full article
(This article belongs to the Special Issue Clinical Management and Challenges in Vaginal Cancer)
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