Diabetic Cardiomyopathy

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: closed (1 August 2020) | Viewed by 29372

Special Issue Editor

Special Issue Information

Dear Colleagues,

Nowadays, obesity is seriously increasing in most of the populations all over the world, and is associated with the development and progression of high-mortality diseases, such as type-2 diabetes mellitus (T2DM) and its subsequent cardiovascular pathologies. In this sense, diabetic cardiomyopathy (DCM) is a cardiac dysfunction, which affects approximately 12% of diabetic patients, leading to overt heart failure and death. DCM is defined by functional and structural changes at the myocardium, independent of any vascular or cardiac disease. However, there is not an efficient and specific methodology for DCM diagnosis, possibly because molecular mechanisms are not fully elucidated, and it remains asymptomatic for many years. In addition, DCM frequently coexists with other comorbidities such as hypertension, obesity, dyslipidemia, and vasculopathies. In this regard, besides imaging techniques, quantification of specific plasma biomarkers related to initial responses, such as cardiac hypertrophy, stiffness and steatosis, may be convenient. In addition, the rising prevalence and accumulating costs of cardiovascular disease in obese and T2DM patients underscore the deficiencies of tertiary prevention and call for a shift in medical treatment. Effective prevention and treatment of DCM may require measures to regulate the metabolic derangement occurring in the heart, rather than merely restoring suitable systemic parameters. Recent research has provided deeper insight into the metabolic etiology of DCM and numerous heart-specific targets that may substitute or reinforce current strategies. Thus, efforts must focus on the need for prospective metabolic targets that may avert myocardial vulnerability and functional decline in next-generation diabetic care.

Dr. Óscar Lorenzo González
Guest Editor

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Keywords

  • Diabetes
  • Obesity
  • Cardiomyopathy
  • Mitochondria Dysfunction
  • Cardiac Metabolism
  • Diagnosis
  • Prognosis
  • Biomarkers
  • Incretin
  • Metformin

Published Papers (2 papers)

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Review

18 pages, 1154 KiB  
Review
Cardiovascular Risks Associated with Gender and Aging
by Jennifer L. Rodgers, Jarrod Jones, Samuel I. Bolleddu, Sahit Vanthenapalli, Lydia E. Rodgers, Kinjal Shah, Krishna Karia and Siva K. Panguluri
J. Cardiovasc. Dev. Dis. 2019, 6(2), 19; https://doi.org/10.3390/jcdd6020019 - 27 Apr 2019
Cited by 486 | Viewed by 24129
Abstract
The aging and elderly population are particularly susceptible to cardiovascular disease. Age is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are compounded by additional factors, including frailty, obesity, and diabetes. These factors are known to complicate and [...] Read more.
The aging and elderly population are particularly susceptible to cardiovascular disease. Age is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are compounded by additional factors, including frailty, obesity, and diabetes. These factors are known to complicate and enhance cardiac risk factors that are associated with the onset of advanced age. Sex is another potential risk factor in aging adults, given that older females are reported to be at a greater risk for CVD than age-matched men. However, in both men and women, the risks associated with CVD increase with age, and these correspond to an overall decline in sex hormones, primarily of estrogen and testosterone. Despite this, hormone replacement therapies are largely shown to not improve outcomes in older patients and may also increase the risks of cardiac events in older adults. This review discusses current findings regarding the impacts of age and gender on heart disease. Full article
(This article belongs to the Special Issue Diabetic Cardiomyopathy )
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11 pages, 1330 KiB  
Review
Non-Invasive Imaging in Diabetic Cardiomyopathy
by Ify R. Mordi
J. Cardiovasc. Dev. Dis. 2019, 6(2), 18; https://doi.org/10.3390/jcdd6020018 - 16 Apr 2019
Cited by 11 | Viewed by 4680
Abstract
There is increasing recognition of a specific diabetic cardiomyopathy beyond ischemic cardiomyopathy, which leads to structural and functional myocardial abnormalities. The aim of this review is to summarize the recent literature on diagnostic findings and prognostic significance of non-invasive imaging including echocardiography, nuclear [...] Read more.
There is increasing recognition of a specific diabetic cardiomyopathy beyond ischemic cardiomyopathy, which leads to structural and functional myocardial abnormalities. The aim of this review is to summarize the recent literature on diagnostic findings and prognostic significance of non-invasive imaging including echocardiography, nuclear imaging, computed tomography and cardiovascular magnetic resonance in diabetic cardiomyopathy. Full article
(This article belongs to the Special Issue Diabetic Cardiomyopathy )
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