How the Detoxification Genes Increase Insect Resistance

A special issue of Insects (ISSN 2075-4450). This special issue belongs to the section "Insect Molecular Biology and Genomics".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1922

Special Issue Editors

Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China
Interests: insecticide resistance; Bt resistance; insect genomics; insect ecology and evolution
Dr. Minghui Jin
E-Mail Website
Guest Editor
Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China
Interests: metabolism and detoxification of xenobiotics in insect; insect ecology and evolution

Special Issue Information

Dear Colleagues, 

An important feature of insect adaptation is the evolution of resistance, including resistance to pesticides, Bt toxins and host plants. The mechanisms of insect resistance are complex and diverse. Current studies believe that the passivation of target receptors and the enhancement of metabolic enzymes are the main contributions to resistance. At present, the research on target receptor passivation is relatively clear, while the mechanism of metabolic enzymes is relatively complex, involving the variation of gene coding region, non-coding region, and regulation outside the functional gene region, which has become a hotspot of current research. This Special Issue focuses on the scientific issue of "How the Detoxification Genes Increase Insects Resistance", and invites contributions of the latest research progress and review from experts and scholars in the field.

Dr. Yutao Xiao
Dr. Minghui Jin
Guest Editors

Manuscript Submission Information

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Keywords

  • detoxification genes
  • insects resistance
  • gene regulation
  • pesticides
  • Bt toxins
  • host plants

Published Papers (1 paper)

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Research

15 pages, 2280 KiB  
Article
Combined PacBio Iso-Seq and Illumina RNA-Seq Analysis of the Tuta absoluta (Meyrick) Transcriptome and Cytochrome P450 Genes
Insects 2023, 14(4), 363; https://doi.org/10.3390/insects14040363 - 06 Apr 2023
Viewed by 1533
Abstract
Tuta absoluta (Meyrick) is a devastating invasive pest worldwide. The abamectin and chlorantraniliprole complex have become an alternative option for chemical control because they can enhance insecticidal activity and delay increased drug resistance. Notably, pests are inevitably resistant to various types of insecticides, [...] Read more.
Tuta absoluta (Meyrick) is a devastating invasive pest worldwide. The abamectin and chlorantraniliprole complex have become an alternative option for chemical control because they can enhance insecticidal activity and delay increased drug resistance. Notably, pests are inevitably resistant to various types of insecticides, and compound insecticides are no exception. To identify potential genes involved in the detoxification of abamectin and chlorantraniliprole complex in T. absoluta, PacBio SMRT-seq transcriptome sequencing and Illumina RNA-seq analysis of abamectin and chlorantraniliprole complex-treated T. absoluta were performed. We obtained 80,492 non-redundant transcripts, 62,762 (77.97%) transcripts that were successfully annotated, and 15,524 differentially expressed transcripts (DETs). GO annotation results showed that most of these DETs were involved in the biological processes of life-sustaining activities, such as cellular, metabolic, and single-organism processes. The KEGG pathway enrichment results showed that the pathways related to glutathione metabolism, fatty acid and amino acid synthesis, and metabolism were related to the response to abamectin and chlorantraniliprole complex in T. absoluta. Among these, 21 P450s were differentially expressed (11 upregulated and 10 downregulated). The qRT-PCR results for the eight upregulated P450 genes after abamectin and chlorantraniliprole complex treatment were consistent with the RNA-Seq data. Our findings provide new full-length transcriptional data and information for further studies on detoxification-related genes in T. absoluta. Full article
(This article belongs to the Special Issue How the Detoxification Genes Increase Insect Resistance)
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