Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJTM
Special Issues
Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0
share announcement

Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0

A special issue of International Journal of Translational Medicine (ISSN 2673-8937).

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 9030

Special Issue Editor

Prof. Dr. Jean-ralph Zahar

E-Mail Website
Guest Editor
1. APHP, Hôpitaux Universitaires de Paris Seine Saint-Denis, 93140 Bondy, France
2. IAME, UMR 1137, Sorbonne Université, Université Paris 13, 75005 Paris, France
Interests: infection control; antimicrobial resistance; antimircrobial stewardship; health acquired infection; environmental contamination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The COVID-19 pandemic has highlighted the importance of anticipating infectious risks and the need for responses adapted to each individual’s epidemiological situation. There has been much debate regarding the interest of specific measures throughout the period; however, beyond that, we have realized the importance of simple but applicable and applied prevention measures. In this future issue, we would like to provide our readers with a cross-sectional reflection including the different actors involved in the control and fight against infectious diseases. The topics discussed will open new horizons not only in the field of prevention, but also in the field of therapy.

I hope that you will join us.

Prof. Dr. Jean-ralph Zahar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Translational Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial stewardship
  • artificial intelligence
  • contact isolation
  • modulization
  • geography
  • behaviors

Related Special Issue

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

9 pages, 313 KiB  
Article
Using the Theory of Planned Behavior and Past Behavior to Explain the Intention to Receive a Seasonal Influenza Vaccine among Family Caregivers of People with Dementia
by Francesco Bruno, Paolo Abondio, Valentina Laganà, Rosanna Colao, Sabrina M. Curcio, Francesca Frangipane, Gianfranco Puccio, Raffaele Di Lorenzo, Amalia C. Bruni and Raffaele Maletta
Int. J. Transl. Med. 2023, 3(2), 246-254; https://doi.org/10.3390/ijtm3020017 - 19 May 2023
Viewed by 1435
Abstract
Older adults with dementia present an increased risk of mortality due to seasonal influenza. Despite concerning evidence, the influenza vaccination program has been unsuccessful, with low rates of uptake in Italian people ≥65 years. In addition, being vaccinated does not eliminate the risk [...] Read more.
Older adults with dementia present an increased risk of mortality due to seasonal influenza. Despite concerning evidence, the influenza vaccination program has been unsuccessful, with low rates of uptake in Italian people ≥65 years. In addition, being vaccinated does not eliminate the risk of contracting a virus, especially by coming into close contact with other possibly unvaccinated people, such as family caregivers in the home environment. Therefore, the refusal of family caregivers to get vaccinated for seasonal influenza could have dire consequences for their relatives with dementia. The aims of this study were to investigate the predictive role of the Theory of Planned Behavior model (TPB) and past vaccination behavior on the intention to receive a seasonal influenza vaccine among family caregivers of people with dementia. Data were collected from seventy-one respondents during July–September 2021 using a cross-sectional web-based survey design. Results of hierarchical binary logistic regression showed that TPB (i.e., attitudes towards vaccination, subjective norms, and perceived behavioral control) explained 51.6% of the variance in intention to receive a seasonal influenza vaccine; past vaccination behavior increased this to 58.8%. In conclusion, past vaccination behavior and the theory of planned behavior variables effectively predict influenza vaccine willingness of family caregivers of people with dementia and should be targeted in vaccination campaigns. Full article
(This article belongs to the Special Issue Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0)
11 pages, 1858 KiB  
Article
Comparison of the Basic Reproduction Numbers for COVID-19 through Four Waves of the Pandemic in Vietnam
by Ngan Thi Mai, Giang Thi Huong Tran, Anh Huu Dang, Phuong Thi Bich Cao, Trung Thanh Nguyen, Huong Thi Lan Pham, Tra Thi Thu Vu, Hieu Van Dong and Le Thi My Huynh
Int. J. Transl. Med. 2023, 3(1), 1-11; https://doi.org/10.3390/ijtm3010001 - 21 Dec 2022
Viewed by 1839
Abstract
Estimating the basic reproduction number (R0) of an infectious disease is a crucial step to describe the contagiousness and provides suggestions for interventions. To lift the effectiveness of preventive measures for the COVID-19 pandemic, we need to minimize the newly infected [...] Read more.
Estimating the basic reproduction number (R0) of an infectious disease is a crucial step to describe the contagiousness and provides suggestions for interventions. To lift the effectiveness of preventive measures for the COVID-19 pandemic, we need to minimize the newly infected cases by reaching adequate herd immunity. This study thus aimed to compare the R0 through four waves of COVID-19 outbreaks in Vietnam and to calculate the minimal vaccination coverage in different populations. The data on the number of daily confirmed COVID-19 patients were collected from 21 January 2020 to 16 November 2021 from the daily reports through the four waves of the pandemic in Vietnam. The R0 values were estimated by exponential growth and the maximum likelihood methods to range from 1.04 to 3.31 from the first to the third wave. The fourth wave was the most severe, especially in the southern provinces, and the highest R0 was in Ho Chi Minh City. The herd immunity would range from 43.50% to 95.76% by various R0 values from different populations. Overall, the presence of new viral mutants increased the infectiousness and the vaccination coverage was higher to establish the required herd immunity in a high-density population. The results provide the basis for policy recommendations and resource allocation for vaccine management and distribution at a time when the COVID-19 pandemic is not yet over. Full article
(This article belongs to the Special Issue Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0)
►▼ Show Figures

Figure 1

8 pages, 495 KiB  
Article
Early Empirical Antibiotic Therapy Modification in Sepsis Using Beta-Lacta Test Directly on Blood Cultures
by Assaf Mizrahi, Françoise Jaureguy, Héloise Petit, Gauthier Péan de Ponfilly, Etienne Carbonnelle, Alban Le Monnier, Jean-Ralph Zahar and Benoît Pilmis
Int. J. Transl. Med. 2022, 2(3), 448-455; https://doi.org/10.3390/ijtm2030034 - 26 Aug 2022
Viewed by 1453
Abstract
Background: Sepsis caused by multi-drug-resistant Gram-negative bacilli lead physicians to prescribe broad-spectrum antibiotic therapy, such as carbapenems. Rapid susceptibility testing can help with the rational use of antibiotics. The aim of this study was to measure the clinical impact associated with rapid [...] Read more.
Background: Sepsis caused by multi-drug-resistant Gram-negative bacilli lead physicians to prescribe broad-spectrum antibiotic therapy, such as carbapenems. Rapid susceptibility testing can help with the rational use of antibiotics. The aim of this study was to measure the clinical impact associated with rapid reporting of Beta-Lacta test (BLT) directly on blood cultures positive with Gram-negative bacilli. Methods: In an observational, multicentric, prospective study, we included patients with sepsis caused by Enterobacterales observed on Gram staining of the positive blood cultures. BLT and antimicrobial susceptibility testing (AST) were performed directly on the blood cultures. Clinical impact was measured on the proportion of patients for whom the probabilistic antibiotic therapy was modified according to BLT, including patients receiving carbapenem. Results: 170 patients were included, of whom 44 (25.9%) were receiving inadequate empirical antibiotic therapy. Among them, 27 (15.9%) benefited from an early modification, according to the BLT results. Among 126 (74.1%) patients receiving appropriate probabilistic antibiotic therapy, we modified the antibiotic therapy for 28 (16.5%) of them, including 4/14 (28.5%) de-escalation from carbapenem to a third-generation cephalosporin. Conclusions: Implementation of BLT performed directly on blood cultures allowed us to rapidly modify the empirical antibiotic therapy for about one-third of patients with sepsis caused by Enterobacterales. Full article
(This article belongs to the Special Issue Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

16 pages, 549 KiB  
Review
Malaria and HIV Co-Infection among Pregnant Women in Africa: Prevalence, Effect on Immunity and Clinical Management: Review
by Bekindaka Ngemani Obase, Jude Daiga Bigoga and Dickson Shey Nsagha
Int. J. Transl. Med. 2023, 3(2), 187-202; https://doi.org/10.3390/ijtm3020014 - 06 Apr 2023
Cited by 2 | Viewed by 2408
Abstract
Malaria and HIV are geographically in the tropics and subtropics of the world, including sub-Saharan Africa. Understanding the overlapping effect of both infections, especially among pregnant women, is crucial in managing pregnant women during antenatal care visits, and postpartum babies. It was realized [...] Read more.
Malaria and HIV are geographically in the tropics and subtropics of the world, including sub-Saharan Africa. Understanding the overlapping effect of both infections, especially among pregnant women, is crucial in managing pregnant women during antenatal care visits, and postpartum babies. It was realized that the prevalence of malaria among HIV-positive pregnant women ranges between 31–61%, while for non-HIV infected pregnant women the prevalence still stands between 10 and 36%. Co-infection is between 0.52 and 56.3%. Even though the rate of mother-to-child transmission of HIV has dropped, MTCT of malaria still remains a problem. MTCT is associated with low birth-weight, anemia, and even immune dysregulation. The adoption of the Option B+ plan has proven to be effective in the fight against the MTCT of HIV. However, malaria in pregnancy still remains a problem. Concurrent administration of both antimalarial drugs and Cotrimozaxole to pregnant women is not recommended, because of the toxic effect of the interaction of both drugs. Nevertheless, studies looking at the effect of the current ART regimens on mothers and their children need to be carried out. Studies looking at exposed children over a longer period of time, to determine their susceptibility to malaria infection and also to monitor their immune response to malaria over time, are needed. Full article
(This article belongs to the Special Issue Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

4 pages, 515 KiB  
Comment
Toxicological Potential of the FDA-Approved Treatment against Monkeypox. Comment on Zovi et al. Pharmacological Agents with Antiviral Activity against Monkeypox Infection. Int. J. Mol. Sci. 2022, 23, 15941
by Gabriel Christian de Farias Morais, Umberto Laino Fulco, Edilson Dantas da Silva, Jr., Claudio Bruno Silva de Oliveira and Jonas Ivan Nobre Oliveira
Int. J. Transl. Med. 2023, 3(2), 183-186; https://doi.org/10.3390/ijtm3020013 - 27 Mar 2023
Viewed by 1048
Abstract
Recently, some drugs were approved to control Monkeypox (MPX), among them tecovirimat. This was recently approved by regulatory agencies around the world, the paper of Zovi et al entitled Pharmacological Agents with Antiviral Activity against Monkeypox Infection highlight it as safe and effective, [...] Read more.
Recently, some drugs were approved to control Monkeypox (MPX), among them tecovirimat. This was recently approved by regulatory agencies around the world, the paper of Zovi et al entitled Pharmacological Agents with Antiviral Activity against Monkeypox Infection highlight it as safe and effective, although the safety data are still not very robust. In this Comment, we present some theoretical evaluations of its safety, considering that for use in humans it is essential to have a rich scientific literature in the area. After a series of analyses, a potential risk of liver, respiratory and kidney damage was found in addition to carcinogenic potential. Thus, while we agree that there is a need for rapid responses to infection, we reinforce that well-designed and adequately powered studies should not only focus on investigating the pharmacological efficacy of tecovirimat but also demonstrate its safety in humans. Therefore, in this Comment, we present some concerns that may help in formulating a safer treatment for patients infected with Monkeypox virus (MPXV). Full article
(This article belongs to the Special Issue Translational Aspects of Infectious Diseases: From Bench to Bedside 2.0)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop