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Bioactives and Nutraceuticals in Metabolic Syndrome II

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 17007

Special Issue Editors


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Guest Editor
Institute of Research, Development and Innovation in Healthcare Biotechnology of Elche (IDiBE), Miguel Hernández University (UMH), Alicante, Spain
Interests: natural compounds; polyphenols; marine compounds; cancer; antimicrobial; skin; cosmetics
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Guest Editor
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain
Interests: bioactive phenolic compounds; metabolomics; analytical techniques; extraction processes; plant and food analysis; bioavailability
Special Issues, Collections and Topics in MDPI journals

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Guest Editor

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a group of metabolic abnormalities, such as insulin resistance, hypertension, dyslipidemia, and excess body fat around the waist that may occur in the same individual. This condition has a remarkable impact on health, leading to shortened life expectancy, and also an increase in the risk of heart diseases. Adults with metabolic syndrome present obesity-associated metabolic, oxidative and inflammatory disturbances. A better understanding of disease-associated metabolic pathway alterations may lead to the identification of new drugs and to the development of new therapies against metabolic abnormalities.

Natural products are a source of anti-inflammatory, antihypertensive, antioxidant, antithrombotic and antihyperglycaemic molecules, possibly useful in the treatment or prevention of metabolic disorders. These compounds could interact in humans with pleiotropic effects in a variety of tissues involved in stress response pathways, thus increasing the ingestion of dietary natural products could be helpful in the management of obesity-related deseases.

This Special Issue is a collection of research and review articles on the benefits of bioactives and nutraceuticals with a special interest in the “New Insights in Natural Compounds in the Management of the Metabolic Syndrome”.

As Guest Editors of this Special Issue, We cordially invite researchers from all around the world to contribute to this Special Issue by submitting original research articles, long and mini review papers, short notes, and opinions according to their expertise.

Dr. Enrique Barrajon
Prof. Dr. David Arráez-Román
Prof. María Herranz-López
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic disorders
  • metabolic pathways
  • bioactives and nutraceuticals
  • obesity
  • AMPK
  • anti-inflammatory
  • antihypertensive
  • antioxidant
  • metabolomics

Published Papers (4 papers)

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Research

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12 pages, 16800 KiB  
Article
Dracunculin Inhibits Adipogenesis in Human Bone Marrow-Derived Mesenchymal Stromal Cells by Activating AMPK and Wnt/β-Catenin Signaling
by Fatih Karadeniz, Jung Hwan Oh, Hyun Jin Jo, Jiho Yang, Hyunjung Lee, Youngwan Seo and Chang-Suk Kong
Int. J. Mol. Sci. 2022, 23(2), 653; https://doi.org/10.3390/ijms23020653 - 7 Jan 2022
Cited by 2 | Viewed by 1836
Abstract
Increased bone marrow adiposity is widely observed in patients with obesity and osteoporosis and reported to have deleterious effects on bone formation. Dracunculin (DCC) is a coumarin isolated from Artemisia spp. but, until now, has not been studied for its bioactive potential except [...] Read more.
Increased bone marrow adiposity is widely observed in patients with obesity and osteoporosis and reported to have deleterious effects on bone formation. Dracunculin (DCC) is a coumarin isolated from Artemisia spp. but, until now, has not been studied for its bioactive potential except antitrypanosomal activity. In this context, current study has reported the anti-adipogenic effect of DCC in human bone marrow-derived mesenchymal stromal cells (hBM-MSCs). DCC dose-dependently inhibited the lipid accumulation and expression of adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα) in hBM-MSCs induced to undergo adipogenesis. To elucidate its action mechanism, the effect of DCC on Wnt/β-catenin and AMPK pathways was examined. Results showed that DCC treatment activated Wnt/β-catenin signaling pathway via AMPK evidenced by increased levels of AMPK phosphorylation and Wnt10b expression after DCC treatment. In addition, DCC treated adipo-induced hBM-MSCs exhibited significantly increased nuclear levels of β-catenin compared with diminished nuclear PPARγ levels. In conclusion, DCC was shown to be able to hinder adipogenesis by activating the β-catenin via AMPK, providing potential utilization of DCC as a nutraceutical against bone marrow adiposity. Full article
(This article belongs to the Special Issue Bioactives and Nutraceuticals in Metabolic Syndrome II)
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17 pages, 3179 KiB  
Article
Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet
by Fernando E. García-Arroyo, Guillermo Gonzaga-Sánchez, Edilia Tapia, Itzel Muñoz-Jiménez, Lino Manterola-Romero, Horacio Osorio-Alonso, Abraham S. Arellano-Buendía, José Pedraza-Chaverri, Carlos A. Roncal-Jiménez, Miguel A. Lanaspa, Richard J. Johnson and Laura Gabriela Sánchez-Lozada
Int. J. Mol. Sci. 2021, 22(5), 2431; https://doi.org/10.3390/ijms22052431 - 28 Feb 2021
Cited by 14 | Viewed by 2871
Abstract
Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of [...] Read more.
Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of osthol in the development of kidney disease induced by a Western (high-fat/high-sugar) diet. Control rats fed with a high-fat/high-sugar diet were compared with two groups that also received two different doses of osthol (30 mg/kg/d or 40 mg/kg/d body weight BW). A fourth group served as a normal control and received regular chow. At the end of the follow-up, kidney function, metabolic markers, oxidative stress, and lipogenic enzymes were evaluated. The Western diet induced MS (hypertension, hyperglycemia, hypertriglyceridemia, obesity, hyperuricemia), a fall in the glomerular filtration rate, renal tubular damage, and increased oxidative stress in the kidney cortex, with increased expression of lipogenic enzymes and increased kidney KHK expression. Osthol treatment prevented the development of MS and ameliorated kidney damage by inhibiting KHK activity, preventing oxidative stress via nuclear factor erythroid 2-related factor (Nrf2) activation, and reducing renal lipotoxicity. These data suggest that the nutraceutical osthol might be an ancillary therapy to slow the progression of MS and kidney damage induced by a Western diet. Full article
(This article belongs to the Special Issue Bioactives and Nutraceuticals in Metabolic Syndrome II)
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Review

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24 pages, 797 KiB  
Review
Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
by Priya Antony and Ranjit Vijayan
Int. J. Mol. Sci. 2021, 22(16), 9059; https://doi.org/10.3390/ijms22169059 - 22 Aug 2021
Cited by 41 | Viewed by 6609
Abstract
Diabetes mellitus is a major public health concern associated with high mortality and reduced life expectancy. The alarming rise in the prevalence of diabetes is linked to several factors including sedentary lifestyle and unhealthy diet. Nutritional intervention and increased physical activity could significantly [...] Read more.
Diabetes mellitus is a major public health concern associated with high mortality and reduced life expectancy. The alarming rise in the prevalence of diabetes is linked to several factors including sedentary lifestyle and unhealthy diet. Nutritional intervention and increased physical activity could significantly contribute to bringing this under control. Food-derived bioactive peptides and protein hydrolysates have been associated with a number health benefits. Several peptides with antidiabetic potential have been identified that could decrease blood glucose level, improve insulin uptake and inhibit key enzymes involved in the development and progression of diabetes. Dietary proteins, from a wide range of food, are rich sources of antidiabetic peptides. Thus, there are a number of benefits in studying peptides obtained from food sources to develop nutraceuticals. A deeper understanding of the underlying molecular mechanisms of these peptides will assist in the development of new peptide-based therapeutics. Despite this, a comprehensive analysis of the antidiabetic properties of bioactive peptides derived from various food sources is still lacking. Here, we review the recent literature on food-derived bioactive peptides possessing antidiabetic activity. The focus is on the effectiveness of these peptides as evidenced by in vitro and in vivo studies. Finally, we discuss future prospects of peptide-based drugs for the treatment of diabetes. Full article
(This article belongs to the Special Issue Bioactives and Nutraceuticals in Metabolic Syndrome II)
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34 pages, 3343 KiB  
Review
Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications
by Shiyao Zhang, Mengyi Xu, Wenxiang Zhang, Chang Liu and Siyu Chen
Int. J. Mol. Sci. 2021, 22(11), 6110; https://doi.org/10.3390/ijms22116110 - 6 Jun 2021
Cited by 41 | Viewed by 4555
Abstract
Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in [...] Read more.
Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Hence, they are expected to be useful in the prevention and management of MetS. At present, epidemiological studies indicate a negative correlation between polyphenol intake and MetS incidence. In this review, we summarized and discussed the most promising natural polyphenols (including flavonoid and non-flavonoid drugs) in the precaution and treatment of MetS, including their anti-inflammatory and antioxidant properties, as well as their regulatory functions involved in glycolipid homeostasis. Full article
(This article belongs to the Special Issue Bioactives and Nutraceuticals in Metabolic Syndrome II)
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