Lipids: From the Structure, Function and Evolution to Applications
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 45693
Interests: biological, bioinorganic, bioorganic and bioanalytical chemistries; drugs for diseases such as tuberculosis, Alzheimer’s diabetes and cancer; organic drugs and transition metal-based drugs; menaquinone, pyrazinamide, metformin, platinum and vanadium derivatives; lipid systems and micro-emulsion environments
Special Issues, Collections and Topics in MDPI journals
Lipidomics is an emerging field of foundational and biomedical research that includes the study of naturally diverse and synthetic lipid biosynthetic pathways, mechanisms to identify and quantify changes to lipid profiles at the cellular and organismal levels, and efforts to leverage distinct lipids for biotechnological approaches. The complex stereochemistry of many lipids and their inherently polar nature often complicate chemical syntheses and isolations, and the radical differences between archaeal and bacterial/eukaryotic lipids provide additional challenges and potential. Diversity in lipid structure is a welcome topic given that archaeal lipids are built on a glycerol-1-phosphate backbone and contain ether-linked isoprenoid chains, while bacterial and eukaryotic lipids are composed of a fatty acid ester linked to a glycerol-3-phosphate. Details on the biological function of distinct lipids, the evolutionary lipid divide, the location(s) and synthesis of unique lipids, including derivation and tetraether monolayers, and the role lipids can play in medicinal settings are of interest. Topics focused on technical advances in areas such as microbiology, mass spectrometry, chemistry, biochemistry, and imaging with respect to lipids are also encouraged. This Special Issue is focused on fundamental studies of diverse lipids as well as their properties and function in biochemical, biological, and medicinal systems.
Potential topics include, but are not limited to, the following:
- Synthesis, isolation, and quantification of natural lipids and lipid derivatives (triglycerides, phospholipids, cholesterol, inositol, fatty acids, second messengers, archaeal lipids, and analogs);
- The evolutionary lipid divide (isoprenoids and retention of lipid biosynthetic pathways in diverse clades, inclusive of redundant or novel pathways for lipid biosynthesis);
- New technologies to explore the biological, physical, structural, and chemical features of lipids and lipid assemblies, including mixed systems;
- Identification and characterization of proteins and enzymes that synthesize, bind, and process lipids;
- Lipid membrane composition, fluidity, properties, and rafting;
- The importance and application of lipids in health and disease;
- Dynamic changes to lipids in environmental extremes.
Prof. Dr. Debbie C. Crans
Dr. Tom Santangelo
Manuscript Submission Information
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