Special Issue "Anti-Tumor Immune Response in Three Dimensional Culture Systems"
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 2492
Interests: mesenchymal stromal cells; NKG2D; innate immunity; leukemia and lymphoma; anti-tumor immunity
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Topical Collection in Cells: Feature Papers in ‘Cellular Immunology’
Special Issue in Cells: 10th Anniversary of Cells—Advances in Cellular Immunology
Topical Collection in Cells: The New Era of Mesenchymal Stromal/Stem Cell Functional Application: State of the Art, Therapeutic Challenges and Future Directions
The immune response has a key role in the regulation of several features of cancer cells, such as growth, expansion, and metastasization. Indeed, it is evident that anti-tumor effector lymphocytes including the innate arm of immune system as natural killer (NK) and innate lymphoid cells (ILC), as well as different subsets of T lymphocytes, can be involved in the regulation of cancer development. Additionally, it is clear that animal models cannot fully resemble the pathophysiological microenvironment that exists during tumor cell growth and selection of tumor cells with the driven mutations which are leading to the uncontrollable expansion of the tumor. On the other hand, the use of three-dimensional (3D) culture systems with either well-established cell lines or primary patient-derived tumor cells that can be a model to study immune response in vitro is becoming more frequent and reliable. These models are mainly tumor spheroids and organoids produced by several artificial means. The immunological studies that can be performed with these 3D culture systems can deal not only with the classical killing of tumor cells but also with the localization and cytokine regulation of immune cells in the context of the spheroid and/or organoid microenvironment. This Special Issue of IJMS will offer an updated overview of the main 3D models applied to study several aspects of the immune response, with a special focus on cancer development and anti-tumor drug selection.
Prof. Dr. Alessandro Poggi
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