Lung Diseases: Chronic Respiratory Infections 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4841
Interests: pneumonia; COPD; bronchiectasis; cystic fibrosis; lung transplantation
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Both chronic and acute infections play a significant role in the pathogenesis and clinical course of chronic obstructive pulmonary disease (COPD) and both cystic fibrosis (CF) and non-CF bronchiectasis. There is also specific evidence that chronic infection, even in the absence of acute infection, has an influence on the manifestations and disease course. The infections found in COPD, CF, and bronchiectasis share a number of clinical similarities, the most striking of which are bacterial persistence despite the use of antibiotics and antibiotic resistance.
In the last two decades, antibiotic resistance rate has increased dramatically and poses serious threats for patients and the public health. There are different reasons for this increase in resistance, but the overuse of antibiotics in the community is certainly the most prominent. On the other hand, chronic use of antibiotics in chronic diseases like COPD, CF and bronchiectasis is also potentially associated to an increase in MDR pathogens. During the last decade, a growing interest has been raised in evaluating nontuberculous mycobacteria’s role in chronic respiratory diseases like bronchiectasis.
Prof. Dr. Francesco B. Blasi
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