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Special Issue "Novel Advances in Development and Application of Nanomaterials"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 6968

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Special Issue Editors

Dr. Han-Jia Lin

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Guest Editor

Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan, China
Interests: aquaculture; biochemistry; carbon nanomaterials; infectious diseaces; microalgae; nanomedicine; nanotoxicity; shrimp

Prof. Dr. Chih-Ching Huang

E-Mail Website
Co-Guest Editor

Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan
Interests: biosensors; anti-pathogenic nanomaterials; nano-anticoagulants; aanozymes

Special Issue Information

Dear Colleagues,

This Special Issue will focus on fundamental research with practical applications of carbon nanomaterials, which can be used as sensor elements, drug delivery systems, or therapeutic agents. Within the wide variety of these materials, we are interested in their preparation, characterization, potential toxicity, and applications to promote the health of humans or animals. Different types of novel indications, such as diagnosis, antibacterial, antiviral, antioxidant, anti-inflammation, and anti-tumor applications, are of practical interest. Another domain of interest is that of carbon nanomaterials, prepared from bioactive molecules and exhibiting extraordinary activity after carbonization.

Dr. Han-Jia Lin
Prof. Dr. Chih-Ching Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

nanomaterials
nanotoxicity
nanogels
carbon-based nanomaterials
metal-based nanomaterials
nanocomposites
fullerenes; nanoparticles
biosensors
therapeutical agents
nanodrug delivery system
antibacterial
antiviral
antioxidant
anti-inflammation

Published Papers (6 papers)

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Research

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Open AccessArticle

Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability

Łukasz Napora-Rutkowski

Ewa Świerczek

and

Maria Augustyniak

Int. J. Mol. Sci. 2023, 24(16), 12826; https://doi.org/10.3390/ijms241612826 - 15 Aug 2023

Viewed by 447

Abstract

The use of nanoparticles like graphene oxide (GO) in nanocomposite industries is growing very fast. There is a strong concern that GO can enter the environment and become nanopollutatnt. Environmental pollutants’ exposure usually relates to low concentrations but may last for a long time and impact following generations. Attention should be paid to the effects of nanoparticles, especially on the DNA stability passed on to the offspring. We investigated the multigenerational effects on two strains (wild and long-lived) of house cricket intoxicated with low GO concentrations over five generations, followed by one recovery generation. Our investigation focused on oxidative stress parameters, specifically AP sites (apurinic/apyrimidinic sites) and 8-OHdG (8-hydroxy-2′-deoxyguanosine), and examined the global DNA methylation pattern. Five intoxicated generations were able to overcome the oxidative stress, showing that relatively low doses of GO have a moderate effect on the house cricket (8-OHdG and AP sites). The last recovery generation that experienced a transition from contaminated to uncontaminated food presented greater DNA damage. The pattern of DNA methylation was comparable in every generation, suggesting that other epigenetic mechanisms might be involved. Full article

(This article belongs to the Special Issue Novel Advances in Development and Application of Nanomaterials)

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Open AccessArticle

Age- and Lifespan-Dependent Differences in GO Caused DNA Damage in Acheta domesticus

Łukasz Napora-Rutkowski

Patrycja Ziętara

Ewa Świerczek

and

Maria Augustyniak

Int. J. Mol. Sci. 2023, 24(1), 290; https://doi.org/10.3390/ijms24010290 - 24 Dec 2022

Viewed by 1068

Abstract

The rising applicability of graphene oxide (GO) should be preceded by detailed tests confirming its safety and lack of toxicity. Sensitivity to GO of immature, or with different survival strategy, individuals has not been studied so far. Therefore, in the present research, we focused on the GO genotoxic effects, examining selected parameters of DNA damage (total DNA damage, double-strand breaks—DSB, 8-hydroxy-2′-deoxyguanosine-8-OHdG, abasic site—AP sites), DNA damage response parameters, and global methylation in the model organism Acheta domesticus. Special attention was paid to various life stages and lifespans, using wild (H), and selected for longevity (D) strains. DNA damage was significantly affected by stage and/or strain and GO exposure. Larvae and young imago were generally more sensitive than adults, revealing more severe DNA damage. Especially in the earlier life stages, the D strain reacted more intensely/inversely than the H strain. In contrast, DNA damage response parameters were not significantly related to stage and/or strain and GO exposure. Stage-dependent DNA damage, especially DSB and 8-OHdG, with the simultaneous lack or subtle activation of DNA damage response parameters, may result from the general life strategy of insects. Predominantly fast-living and fast-breeding organisms can minimize energy-demanding repair mechanisms. Full article

(This article belongs to the Special Issue Novel Advances in Development and Application of Nanomaterials)

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Open AccessArticle

A Multichannel Fluorescent Tongue for Amyloid-β Aggregates Detection

and

Int. J. Mol. Sci. 2022, 23(23), 14562; https://doi.org/10.3390/ijms232314562 - 23 Nov 2022

Viewed by 1440

Abstract

Attention has been paid to the early diagnosis of Alzheimer’s disease, due to the maximum benefit acquired from the early-stage intervention and treatment. However, the sensing techniques primarily depended upon for neuroimaging and immunological assays for the detection of AD biomarkers are expensive, time-consuming and instrument dependent. Here, we developed a multichannel fluorescent tongue consisting of four fluorescent dyes and GO through electrostatic and π–π interaction. The array distinguished multiple aggregation states of 1 µM Aβ40/Aβ42 with 100% prediction accuracy via 10-channel signal outputs, illustrating the rationality of the array design. Screening vital sensor elements for the simplified sensor array and the optimization of sensing system was achieved by machine learning algorithms. Moreover, our sensing tongue was able to detect the aggregation states of Aβ40/Aβ42 in serum, demonstrating the great potential of multichannel array in diagnosing the Alzheimer’s diseases. Full article

(This article belongs to the Special Issue Novel Advances in Development and Application of Nanomaterials)

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Open AccessArticle

Study on Long-Term Tracing of Fibroblasts on Three-Dimensional Tissue Engineering Scaffolds Based on Graphene Quantum Dots

and

Int. J. Mol. Sci. 2022, 23(19), 11040; https://doi.org/10.3390/ijms231911040 - 20 Sep 2022

Cited by 1 | Viewed by 960

Abstract

In order to find a convenient and stable way to trace human skin fibroblasts (HSFs) in three-dimensional tissue engineering scaffolds for a long time, in this experiment, Graphene Oxide Quantum Dots (GOQDs), Amino Graphene Quantum Dots (AGQDs) and Carboxyl Graphene Quantum Dots (CGQDs) were used as the material source for labeling HSFs. Exploring the possibility of using it as a long-term tracer of HSFs in three-dimensional tissue engineering scaffolds, the contents of the experiment are as follows: the HSFs were cultured in a cell-culture medium composed of three kinds of Graphene Quantum Dots for 24 h, respectively; (1) using Cell Counting Kit 8 (CCK8), Transwell migration chamber and Phalloidin-iFlior 488 to detect the effect of Graphene Quantum Dots on the biocompatibility of HSFs; (2) using a living cell workstation to detect the fluorescence labeling results of three kinds of Graphene Quantum Dots on HSFs, and testing the fluorescence attenuation of HSFs for 7 days; (3) the HSFs labeled with Graphene Quantum Dots were inoculated on the three-dimensional chitosan demethylcellulose sodium scaffold, and the living cell workstation was used to detect the spatial distribution of the HSFs on the three-dimensional scaffold through the fluorescence properties of the HSFs.. Experimental results: (1) the results of CCK8, Transwell migration, and FITC-Phalloidin cytoskeleton test showed that the three kinds of Graphene Quantum Dots had no effect on the biological properties of HSFs (p < 0.05); (2) the results of the fluorescence labeling experiment showed that only AGQDs could make HSFs fluorescent, and cells showed orange–red fluorescence; (3) the results of long-range tracing of HSFs which were labeled by with AGQDs showed that the fluorescence life of the HSFs were as long as 7 days; (4) The spatial distribution of HSFs can be detected on the three-dimensional scaffold based on their fluorescence properties, and the detection time can be up to 7 days. Full article

(This article belongs to the Special Issue Novel Advances in Development and Application of Nanomaterials)

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Review

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Open AccessReview

Carbon Nanomaterials: Emerging Roles in Immuno-Oncology

and

Int. J. Mol. Sci. 2023, 24(7), 6600; https://doi.org/10.3390/ijms24076600 - 01 Apr 2023

Viewed by 1095

Abstract

Cancer immunotherapy has made breakthrough progress in cancer treatment. However, only a subset of patients benefits from immunotherapy. Given their unique structure, composition, and interactions with the immune system, carbon nanomaterials have recently attracted tremendous interest in their roles as modulators of antitumor immunity. Here, we focused on the latest advances in the immunological effects of carbon nanomaterials. We also reviewed the current preclinical applications of these materials in cancer therapy. Finally, we discussed the challenges to be overcome before the full potential of carbon nanomaterials can be utilized in cancer therapies to ultimately improve patient outcomes. Full article

(This article belongs to the Special Issue Novel Advances in Development and Application of Nanomaterials)

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Open AccessReview

Sensing and Stimulation Applications of Carbon Nanomaterials in Implantable Brain-Computer Interface

and

Int. J. Mol. Sci. 2023, 24(6), 5182; https://doi.org/10.3390/ijms24065182 - 08 Mar 2023

Cited by 1 | Viewed by 1383

Abstract

Implantable brain–computer interfaces (BCIs) are crucial tools for translating basic neuroscience concepts into clinical disease diagnosis and therapy. Among the various components of the technological chain that increases the sensing and stimulation functions of implanted BCI, the interface materials play a critical role. Carbon nanomaterials, with their superior electrical, structural, chemical, and biological capabilities, have become increasingly popular in this field. They have contributed significantly to advancing BCIs by improving the sensor signal quality of electrical and chemical signals, enhancing the impedance and stability of stimulating electrodes, and precisely modulating neural function or inhibiting inflammatory responses through drug release. This comprehensive review provides an overview of carbon nanomaterials’ contributions to the field of BCI and discusses their potential applications. The topic is broadened to include the use of such materials in the field of bioelectronic interfaces, as well as the potential challenges that may arise in future implantable BCI research and development. By exploring these issues, this review aims to provide insight into the exciting developments and opportunities that lie ahead in this rapidly evolving field. Full article

(This article belongs to the Special Issue Novel Advances in Development and Application of Nanomaterials)

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Special Issue "Novel Advances in Development and Application of Nanomaterials"

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