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Processing of Carbohydrate Polymers for Tissue Engineering and Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 3303

Special Issue Editors

Dr. Isabelle Texier
E-Mail Website
Guest Editor
Leti, Technology Research Institute, France
Centre de Recherches sur les Macromolécules Végétales (CERMAV)-CNRS, University Grenoble Alpes, 38400 Saint Martin d'Heres, France
Interests: biomaterial design; polysaccharide hydrogels; drug delivery nanosystems; stem cell therapy, cancer therapy, 3D bioprinting

Special Issue Information

Dear Colleagues,

Carbohydrate polymers are key building blocks in many materials dedicated to biomedical applications. They are selected for their biocompatibility, degradability, natural occurrence in living tissues, and biological properties (e.g., mucoadhesion, anticoagulant activity, etc.). They also offer extensive possibilities of chemical modification and combination with other building blocks (e.g., synthetic or biopolymers, nanoparticles, etc.). This enables the design of complex and multifunctional materials endowed with properties such as stretchability, mechanical strength, biological or chemical sensing, electrical conductivity, self-healing, or shape morphing ability. Interestingly, depending on the processing method, they can be obtained in different shapes to better fit specific medical applications: fibers, nano- or microparticles, injectable or printable hydrogels, films and coatings, aerogels, or cryogels. However, challenges should still be overcome to expand the translation of such materials to the clinical field. Because of the complexity, multifunctionality, and sometimes fragility of such materials, processing is one such challenge. To enable preclinical and clinical testing of polysaccharide-based medical devices, there is presently a huge need to develop innovative processing methods or consolidate existing ones, with the idea of improving their robustness, batch-to-batch reproducibility, scale-up possibility, and taking into account good GMPs and sterilization constraints.

This Special Issue will cover a selection of recent research topics and current review articles in the field of processing methods of carbohydrate polymer-based materials, which include for instance advanced cross-linking methods, soft microfabrication (e.g., molding, photolithography, bioprinting, etc.), freeze-drying, electro-spinning, or the use of microfluidics. Topics on original carbohydrate polymer materials in relation to processing methods in medical devices and clinical translation are also welcome.

Dr. Isabelle Texier
Prof. Dr. Rachel Auzély
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrospun fibers
  • aerogels
  • cryogels
  • patterned hydrogels
  • injectable hydrogels
  • bioinks
  • stimuli- responsible hydrogels
  • nanoparticles
  • microparticles
  • self-healing materials
  • shape-morphing materials
  • smart actuators

Published Papers (1 paper)

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Research

13 pages, 4162 KiB  
Article
Encapsulation of Micro- and Milli-Sized Particles with a Hollow-Type Spherical Bacterial Cellulose Gel via Particle-Preloaded Droplet Cultivation
Int. J. Mol. Sci. 2019, 20(19), 4919; https://doi.org/10.3390/ijms20194919 - 04 Oct 2019
Cited by 5 | Viewed by 2945
Abstract
A hollow-type spherical bacterial cellulose (HSBC) gel prepared using conventional methods cannot load particles larger than the pore size of the cellulose nanofiber network of bacterial cellulose (BC) gelatinous membranes. In this study, we prepared a HSBC gel encapsulating target substances larger than [...] Read more.
A hollow-type spherical bacterial cellulose (HSBC) gel prepared using conventional methods cannot load particles larger than the pore size of the cellulose nanofiber network of bacterial cellulose (BC) gelatinous membranes. In this study, we prepared a HSBC gel encapsulating target substances larger than the pore size of the BC gelatinous membranes using two encapsulating methods. The first method involved producing the BC gelatinous membrane on the surface of the core that was a spherical alginate gel with a diameter of 2 to 3 mm containing the target substances. With this method, the BC gelatinous membrane was biosynthesized using Gluconacetobacter xylinus at the interface between the cell suspension attached onto the alginate gel and the silicone oil. The second method involved producing the BC gel membrane on the interface between the silicone oil and cell suspension, as well as the spherical alginate gel with a diameter of about 1 mm containing target substances. After the BC gelatinous membrane was biosynthesized, an alginate gel was dissolved in a phosphate buffer to prepare an HSBC gel with the target substances. These encapsulated substances could neither pass through the BC gelatinous membrane of the HSBC gel nor leak from the interior space of the HSBC gel. These results suggest that the HSBC gel had a molecular sieving function. The HSBC gel walls prepared using these methods were observed to be uniform and would be useful for encapsulating bioactive molecules, such as immobilized enzymes in HSBC gel, which is expected to be used as a drug carrier. Full article
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