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Biomimetic Materials in Tissue Engineering

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 6147

Special Issue Editors


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Guest Editor
Department of Neuroscience, Section of Human Anatomy, University of Padova, 35121 Padova, Italy
Interests: gross and microscopic anatomy; synthetic/biological scaffolds; stem cells; cells-scaffolds interactions; preclinical studies
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Section of Human Anatomy, Department of Neuroscience, University of Padova, 35122 Padova, Italy
Interests: neuroscience; neuroanatomy; peripheral arterial chemoreceptors; carotid body; neuropeptides; receptors; hyperoxia; hypoxia; plasticity; clinical anatom
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Neuroscience, Section of Human Anatomy, University of Padova, 35121 Padova, Italy
Interests: gross and microscopic anatomy; decellularization; polymeric scaffolds; stem cells; cell–scaffold interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The fabrication of effective tissue-like scaffolds for tissue engineering purposes is an intriguing challenge in material science. Biomimetic materials are expected to reproduce extracellular matrix (ECM) characteristics, assuring highly complex engineered 3D structures that instead of replacing a mere function can trigger the regeneration of a functional tissue. It follows that the development of bioactive tissue substitutes inspired by anatomy is an ambitious goal. Intense efforts are required in different but complementary research fields to ensure a dynamic cross-talk among scaffolds’ specific constituents and a future fine interaction of the system with the surrounding in vivo environment. Given the growing interest in effective tissue-engineering strategies, driven by the urgent need to respond to patients’ healthcare needs, this Special Issue focuses on some of the main features related to the development of bioinspired and biomimetic materials, including: materials bioactivation strategies, new processing technologies for tissue biomimicry, the identification and description of strategies to promote cell/material interactions, the development of materials supporting delivery strategies (bioactive cues, cells), and preclinical comparative studies evaluating materials’ effectiveness in tissue regeneration based on biomolecular recognition. We welcome the submission of manuscripts, both original articles and reviews, that address recent advances in biomimetic materials.

Dr. Elena Stocco
Dr. Andrea Porzionato
Dr. Silvia Barbon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anatomy-inspired materials
  • peptides
  • nanomaterials
  • bioactive cues
  • extracellular matrix
  • bioactivation strategies
  • cell–material interactions
  • ultrastructure
  • scaffold mechanics
  • delivery strategies
  • 3D printing

Published Papers (3 papers)

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Research

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18 pages, 4542 KiB  
Article
Photochemically Aided Arteriovenous Fistula Creation to Accelerate Fistula Maturation
by Yong He, Blake Anderson, Qiongyao Hu, RB Hayes, Kenji Huff, Jim Isaacson, Kevin S. Warner, Hank Hauser, Myles Greenberg, Venita Chandra, Katalin Kauser and Scott A. Berceli
Int. J. Mol. Sci. 2023, 24(8), 7571; https://doi.org/10.3390/ijms24087571 - 20 Apr 2023
Cited by 2 | Viewed by 1460
Abstract
Rates of arteriovenous fistula maturation failure are still high, especially when suboptimal size veins are used. During successful maturation, the vein undergoes lumen dilatation and medial thickening, adapting to the increased hemodynamic forces. The vascular extracellular matrix plays an important role in regulating [...] Read more.
Rates of arteriovenous fistula maturation failure are still high, especially when suboptimal size veins are used. During successful maturation, the vein undergoes lumen dilatation and medial thickening, adapting to the increased hemodynamic forces. The vascular extracellular matrix plays an important role in regulating these adaptive changes and may be a target for promoting fistula maturation. In this study, we tested whether a device-enabled photochemical treatment of the vein prior to fistula creation facilitates maturation. Sheep cephalic veins were treated using a balloon catheter coated by a photoactivatable molecule (10-8-10 Dimer) and carrying an internal light fiber. As a result of the photochemical reaction, new covalent bonds were created during light activation among oxidizable amino acids of the vein wall matrix proteins. The treated vein lumen diameter and media area became significantly larger than the contralateral control fistula vein at 1 week (p = 0.035 and p = 0.034, respectively). There was also a higher percentage of proliferating smooth muscle cells in the treated veins than in the control veins (p = 0.029), without noticeable intimal hyperplasia. To prepare for the clinical testing of this treatment, we performed balloon over-dilatation of isolated human veins and found that veins can tolerate up to 66% overstretch without notable histological damage. Full article
(This article belongs to the Special Issue Biomimetic Materials in Tissue Engineering)
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24 pages, 109523 KiB  
Article
Development of Two-Layer Hybrid Scaffolds Based on Oxidized Polyvinyl Alcohol and Bioactivated Chitosan Sponges for Tissue Engineering Purposes
by Elena Stocco, Silvia Barbon, Elena Zeni, Leonardo Cassari, Annj Zamuner, Antonio Gloria, Teresa Russo, Rafael Boscolo-Berto, Maria Martina Sfriso, Veronica Macchi, Raffaele De Caro, Monica Dettin and Andrea Porzionato
Int. J. Mol. Sci. 2022, 23(20), 12059; https://doi.org/10.3390/ijms232012059 - 11 Oct 2022
Cited by 5 | Viewed by 1881
Abstract
Oxidized polyvinyl alcohol (OxPVA) is a new polymer for the fabrication of nerve conduits (NCs). Looking for OxPVA device optimization and coupling it with a natural sheath may boost bioactivity. Thus, OxPVA/chitosan sponges (ChS) as hybrid scaffolds were investigated to predict in the [...] Read more.
Oxidized polyvinyl alcohol (OxPVA) is a new polymer for the fabrication of nerve conduits (NCs). Looking for OxPVA device optimization and coupling it with a natural sheath may boost bioactivity. Thus, OxPVA/chitosan sponges (ChS) as hybrid scaffolds were investigated to predict in the vivo behaviour of two-layered NCs. To encourage interaction with cells, ChS were functionalized with the self-assembling-peptide (SAP) EAK, without/with the laminin-derived sequences -IKVAV/-YIGSR. Thus, ChS and the hybrid scaffolds were characterized for mechanical properties, ultrastructure (Scanning Electron Microscopy, SEM), bioactivity, and biocompatibility. Regarding mechanical analysis, the peptide-free ChS showed the highest values of compressive modulus and maximum stress. However, among +EAK groups, ChS+EAK showed a significantly higher maximum stress than that found for ChS+EAK-IKVAV and ChS+EAK-YIGSR. Considering ultrastructure, microporous interconnections were tighter in both the OxPVA/ChS and +EAK groups than in the others; all the scaffolds induced SH-SY5Y cells’ adhesion/proliferation, with significant differences from day 7 and a higher total cell number for OxPVA/ChS+EAK scaffolds, in accordance with SEM. The scaffolds elicited only a slight inflammation after 14 days of subcutaneous implantation in Balb/c mice, proving biocompatibility. ChS porosity, EAK 3D features and neuro-friendly attitude (shared with IKVAV/YIGSR motifs) may confer to OxPVA certain bioactivity, laying the basis for future appealing NCs. Full article
(This article belongs to the Special Issue Biomimetic Materials in Tissue Engineering)
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Review

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23 pages, 4601 KiB  
Review
Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite
by Yifan Niu, Lei Chen and Tianfu Wu
Int. J. Mol. Sci. 2023, 24(15), 12492; https://doi.org/10.3390/ijms241512492 - 06 Aug 2023
Cited by 4 | Viewed by 1991
Abstract
The natural healing process of bone is impaired in the presence of tumors, trauma, or inflammation, necessitating external assistance for bone regeneration. The limitations of autologous/allogeneic bone grafting are still being discovered as research progresses. Bone tissue engineering (BTE) is now a crucial [...] Read more.
The natural healing process of bone is impaired in the presence of tumors, trauma, or inflammation, necessitating external assistance for bone regeneration. The limitations of autologous/allogeneic bone grafting are still being discovered as research progresses. Bone tissue engineering (BTE) is now a crucial component of treating bone injuries and actively works to promote vascularization, a crucial stage in bone repair. A biomaterial with hydroxyapatite (HA), which resembles the mineral makeup of invertebrate bones and teeth, has demonstrated high osteoconductivity, bioactivity, and biocompatibility. However, due to its brittleness and porosity, which restrict its application, scientists have been prompted to explore ways to improve its properties by mixing it with other materials, modifying its structural composition, improving fabrication techniques and growth factor loading, and co-cultivating bone regrowth cells to stimulate vascularization. This review scrutinizes the latest five-year research on HA composite studies aimed at amplifying vascularization in bone regeneration. Full article
(This article belongs to the Special Issue Biomimetic Materials in Tissue Engineering)
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