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Special Issue "Antibodies in Autoimmune Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 1098
Special Issue Editors
Interests: tissue culturing; hybridoma technology; monoclonal antibody production and characterization
Interests: lymphoid; animal models of autoimmunity; Immunology
Special Issue Information
In a healthy individual the immune system can distinguish between self and non-self antigens, and respond accordingly with an active immune response against external pathogens and modified self-structures, but will protect normal self-structures and establish tolerance against these. There are several components of the tolerance induction, including natural autoantibodies, regulatory T and B cells, and the selection of lymphocytes in the primary lymphoid organs.
Autoimmune diseases arise from unregulated immune responses against self-molecules. Their development is influenced by genetic and environmental factors, age and hormones. There are more than 80 types of autoimmune diseases mediated or marked by autoantibodies, which can be classified into systemic or organ-specific diseases. Pathogenic autoantibodies contribute to the disease mechanism in a number of ways, including the deposition of immune complexes, the induction of inflammation, and the stimulation or inhibition of receptor or enzyme functions, thus affecting cellular signaling or metabolism. The detection of new disease-related autoantibodies can help in the diagnosis of the disease, or can be a marker of the efficacy of the therapy. In addition, understanding the biology of autoimmunity-linked B-cell subsets and their roles through animal models may pave the way towards more efficient therapy, coupled with less-severe side effects.
This Special Issue aims to present the latest research results and new views on the cellular and molecular aspects of processes resulting in autoantibody production, autoimmune B-cell formation and their relevance to autoimmune diseases. We aim to bring together exciting new developments in this field. Both original research articles and comprehensive reviews are welcomed.
Prof. Dr. Tímea Berki
Prof. Dr. Péter Balogh
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- autoimmune diseases
- autoimmune B-cell
- autoimmunity-linked B-cell subsets
- animal models
- cellular signaling/metabolism
- targeted therapies