Special Issue "Antibodies in Autoimmune Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 1098
Special Issue Editors
Interests: tissue culturing; hybridoma technology; monoclonal antibody production and characterization
Interests: lymphoid; animal models of autoimmunity; Immunology
Special Issue Information
Dear Colleagues,
In a healthy individual the immune system can distinguish between self and non-self antigens, and respond accordingly with an active immune response against external pathogens and modified self-structures, but will protect normal self-structures and establish tolerance against these. There are several components of the tolerance induction, including natural autoantibodies, regulatory T and B cells, and the selection of lymphocytes in the primary lymphoid organs.
Autoimmune diseases arise from unregulated immune responses against self-molecules. Their development is influenced by genetic and environmental factors, age and hormones. There are more than 80 types of autoimmune diseases mediated or marked by autoantibodies, which can be classified into systemic or organ-specific diseases. Pathogenic autoantibodies contribute to the disease mechanism in a number of ways, including the deposition of immune complexes, the induction of inflammation, and the stimulation or inhibition of receptor or enzyme functions, thus affecting cellular signaling or metabolism. The detection of new disease-related autoantibodies can help in the diagnosis of the disease, or can be a marker of the efficacy of the therapy. In addition, understanding the biology of autoimmunity-linked B-cell subsets and their roles through animal models may pave the way towards more efficient therapy, coupled with less-severe side effects.
This Special Issue aims to present the latest research results and new views on the cellular and molecular aspects of processes resulting in autoantibody production, autoimmune B-cell formation and their relevance to autoimmune diseases. We aim to bring together exciting new developments in this field. Both original research articles and comprehensive reviews are welcomed.
Prof. Dr. Tímea Berki
Prof. Dr. Péter Balogh
Guest Editors
Manuscript Submission Information
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Keywords
- autoimmune diseases
- autoantibodies
- autoimmune B-cell
- autoimmunity-linked B-cell subsets
- animal models
- cellular signaling/metabolism
- targeted therapies
