Targeting Inflammaging and Degeneration by Amino Acids
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3122
Special Issue Editor
Interests: aging; amino acids; antioxidants; inflammaging; melatonin; product development; tryptophan
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The process of ageing and stress or aberrant signaling-induced senescence can induce inflammation and degeneration. Oxidative stress affects signaling pathways for metabolic protein turnover that can recruit malfunctioning aberrant proteins and compounds that trigger inflammatory processes. Although various cell types, such as skin cells, fibroblasts, muscle cells, parenchymal cells, immune cells, neurons, endocrine, endothelial and fat cells, are involved in secreting proinflammatory signals, the lack of trophic prosurvival signaling by amino acids and the resulting insufficient antioxidative protection by amino acid metabolites derived from the symbiotic organisms in the gastrointestinal tract and the endothelial cells of the cardiovascular system or the myocytes from the muscles seem to contribute most to age-dependent inflammatory processes that impair health. Recent studies have emphasized the role of metabolic mitochondrial dysregulation in degenerative inflammatory diseases.
This Special Issue focuses on these detrimental metabolic und immune responses during ageing and invites contributions to this rapidly developing field of research with special emphasis on approaches that successfully target inflammation and degeneration by providing amino acids as the decisive molecules enabling endogenous regeneration.
Dr. Burkhard Poeggeler
Guest Editor
Manuscript Submission Information
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Keywords
- amino acid
- inflammation
- degeneration
- proinflammatory signals
- oxidative stress
- antioxidative protection
- metabolites
