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Pathogenesis and Novel Therapeutic Approaches for Sarcomas

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 686

Special Issue Editor

Dr. Francisco Giner
E-Mail Website
Guest Editor
Department of Pathology, University Hospital “La Fe”, 46009 Valencia, Spain
Interests: soft tissue and bone tumors; colon cancer; inflammatory bowel disease

Special Issue Information

Dear Colleagues,

Malignant bone and soft tissue tumors (sarcomas) are relatively common neoplasms. Some of them are typical of the pediatric age, with all the social, medical, and family stress that this entails. In general, low-grade tumors show a tendency of local recurrence and are often difficult to resect surgically depending on the location. In addition, low-grade sarcomas do not usually show a good response to adjuvant cancer treatments. On the other hand, high-grade sarcomas are very aggressive and have a tendency to metastasize at a distance, and although they show a better response to cancer treatment they usually create resistance to them over time, and the disease ends up progressing. For all of these reasons, it is important to find new therapeutic targets that help us control the spread and progression of the disease. For this, it is important to study the structure, immunophenotype, and molecular alterations of each tumor that help us to better understand the biology of this characteristic group of neoplasms.

Dr. Francisco Giner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • soft tissue tumors
  • bone tumors
  • molecular biology
  • target therapies

Published Papers (1 paper)

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Review

11 pages, 264 KiB  
Review
Recent Advances in the Diagnosis, Pathogenesis, and Management of Myxoinflammatory Fibroblastic Sarcoma
Int. J. Mol. Sci. 2024, 25(2), 1127; https://doi.org/10.3390/ijms25021127 - 17 Jan 2024
Viewed by 466
Abstract
Myxoinflammatory fibroblastic sarcoma (MIFS) is an infiltrative, locally aggressive fibroblastic neoplasm of intermediate malignancy that typically arises in the distal extremities of middle-aged adults. It can histologically be confused with a number of benign and malignant conditions. Recently, high-grade examples of MIFS have [...] Read more.
Myxoinflammatory fibroblastic sarcoma (MIFS) is an infiltrative, locally aggressive fibroblastic neoplasm of intermediate malignancy that typically arises in the distal extremities of middle-aged adults. It can histologically be confused with a number of benign and malignant conditions. Recently, high-grade examples of MIFS have been described. Immunohistochemistry plays a very limited role in the diagnosis of MIFS. Several genetic alterations have been identified in MIFS, including a t(1;10)(p22;q24) translocation with TGFBR3 and/or OGA rearrangements, BRAF rearrangement, and VGLL3 amplification. Although it appears that VGLL3 amplification is the most consistent alteration, the molecular pathogenesis of MIFS remains poorly understood. A wide resection is considered the standard treatment for MIFS. Radiotherapy may be a viable option in cases with inadequate surgical margins or cases where surgery is likely to cause significant functional impairment. The systemic treatment options for advanced or metastatic disease are very limited. This review provides an updated overview of the clinicoradiological features, pathogenesis, histopathology, and treatment of MIFS. Full article
(This article belongs to the Special Issue Pathogenesis and Novel Therapeutic Approaches for Sarcomas)
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