Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Molecular Features of Growth Factors Applied to Tissue Engineering

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 5956

Share This Special Issue

Special Issue Editor

Prof. Dr. Marco Cicciu

E-Mail Website
Guest Editor

Department of General Surgery and Surgical-Medical Specialties, University of Catania, Via S. Sofia 78, 95124 Catania, Italy
Interests: prosthesis; prosthodontics; material sciences; oral surgery; tissue engineering; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that tissue engineering is today a great challenge for clinicians and researchers who aim to perform safe and predictable regenerative procedures in the field of medicine. In recent years, growth factors applied to regenerative and reconstructive medicine have been introduced as a therapeutic option in the treatment of several congenital and acquired bone defects after tumor resection or trauma. Although there have been promising clinical results, the international literature is still lacking complete guidelines, including limits and indications, for the use of growth factors and their carriers.
In the near future, the use of tissue engineering as well as the application of exogenous cytokines, particularly those in the BMPs series, will become common and the regeneration of osseous defects will likely be carried out as a clinical outpatient procedure. In this Special Issue, we want to provide a global overview of the advances in growth factor applications from molecular and clinical points of view, ranging from the new discoveries in the field in tissue engineering to the molecular etiological aspects of the biomaterials applied as carriers. This Issue will also cover new advances in preclinical molecular therapeutic strategies for managing large body resection treatment by using tissue engineering.

On behalf of the International Journal of Molecular Science, you are cordially invited to contribute an article to the Special Issue “Molecular and Clinical Features of Growth Factors Applied to Tissue Engineering”.

Prof. Dr. Marco Cicciu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Tissue Engineering
Bone Regeneration
Regenerative Surgery
Biomaterials
Growth Factors
Biomaterials

Published Papers (3 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Editorial

Jump to: Research

4 pages, 404 KiB

Open AccessEditorial

Growth Factor Applied to Oral and Regenerative Surgery

by Marco Cicciù

Int. J. Mol. Sci. 2020, 21(20), 7752; https://doi.org/10.3390/ijms21207752 - 20 Oct 2020

Cited by 7 | Viewed by 1822

Abstract

The complex tissue engineering/regenerative medicine now represents a therapeutic reality applicable to various organic substrates, with the aim of repairing deficient tissues and restoring normal organ function. Among the possible specialized uses, in the dental field, the treatment of periodontal, pre- and peri-implant bone defects should be mentioned. Nowadays, in oral surgery, there are many surgical methods that can be used, despite that the literature still seems controversial regarding the actual advantages of their use. Surely, this work will bring to light the current clinical-surgical orientations and the different perspectives. Full article

(This article belongs to the Special Issue Molecular Features of Growth Factors Applied to Tissue Engineering)

► Show Figures

Figure 1

Research

Jump to: Editorial

17 pages, 16058 KiB

Open AccessArticle

Synergistic Effect of QNZ, an Inhibitor of NF-κB Signaling, and Bone Morphogenetic Protein 2 on Osteogenic Differentiation in Mesenchymal Stem Cells through Fibroblast-Induced Yes-Associated Protein Activation

by Fei Huang, Hai Wang, Ying Zhang, Guozhen Wei, Yun Xie and Gui Wu

Int. J. Mol. Sci. 2023, 24(9), 7707; https://doi.org/10.3390/ijms24097707 - 22 Apr 2023

Cited by 1 | Viewed by 1158

Abstract

Biomaterials carrying recombinant human bone morphogenetic protein 2 (BMP2) have been developed to enhance bone regeneration in the treatment of bone defects. However, various reports have shown that in the bone repair microenvironment, fibroblasts can inhibit BMP2-induced osteogenic differentiation in mesenchymal stem cells (MSCs). Thus, factors that can target fibroblasts and improve BMP2-mediated osteogenesis should be explored. In this project, we focused on whether or not an inhibitor of the NF-κB signaling pathway, QNZ (EVP4593), could play a synergistic role with BMP2 in osteogenesis by regulating the activity of fibroblasts. The roles of QNZ in regulating the proliferation and migration of fibroblasts were examined. In addition, the effect of QNZ combined with BMP2 on the osteogenic differentiation of MSCs was evaluated both in vitro and in vivo. Furthermore, the detailed mechanisms by which QNZ improved BMP2-mediated osteogenesis through the modulation of fibroblasts were analyzed and revealed. Interestingly, we found that QNZ inhibited the proliferation and migration of fibroblasts. Thus, QNZ could relieve the inhibitory effects of fibroblasts on the homing and osteogenic differentiation of mesenchymal stem cells. Furthermore, biomaterials carrying both QNZ and BMP2 showed better osteoinductivity than did those carrying BMP2 alone both in vitro and in vivo. It was found that the mechanism of QNZ involved reactivating YAP activity in mesenchymal stem cells, which was inhibited by fibroblasts. Taken together, our results suggest that QNZ may be a candidate factor for assisting BMP2 in inducing osteogenesis. The combined application of QNZ and BMP2 in biomaterials may be promising for the treatment of bone defects in the future. Full article

(This article belongs to the Special Issue Molecular Features of Growth Factors Applied to Tissue Engineering)

► Show Figures

Figure 1

15 pages, 6027 KiB

Open AccessArticle

First Experimental Study of the Influence of Extracellular Vesicles Derived from Multipotent Stromal Cells on Osseointegration of Dental Implants

by Igor Maiborodin, Aleksandr Shevela, Vera Matveeva, Vitaly Morozov, Michael Toder, Sergey Krasil’nikov, Alina Koryakina, Andrew Shevela and Oleg Yanushevich

Int. J. Mol. Sci. 2021, 22(16), 8774; https://doi.org/10.3390/ijms22168774 - 16 Aug 2021

Cited by 2 | Viewed by 1666

Abstract

Herein, the aim was to study the state of the bone tissue adjacent to dental implants after the use of extracellular vesicles derived from multipotent stromal cells (MSC EVs) of bone marrow origin in the experiment. In compliance with the rules of asepsis and antiseptics under general intravenous anesthesia with propofol, the screw dental implants were installed in the proximal condyles of the tibia of outbred rabbits without and with preliminary introduction of 19.2 μg MSC EVs into each bone tissue defect. In 3, 7, and 10 days after the operation, the density of bone tissue adjacent to different parts of the implant using an X-ray unit with densitometer was measured. In addition, the histological examinations of the bone site with the hole from the removed device and the soft tissues from the surface of the proximal tibial condyle in the area of intra-bone implants were made. It was found out that 3 days after implantation with the use of MSC EVs, the bone density was statistically significantly higher by 47.2% than after the same implantation, but without the injection of MSC EVs. It is possible that as a result of the immunomodulatory action of MSC EVs, the activity of inflammation decreases, and, respectively, the degree of vasodilation in bones and leukocyte infiltration of the soft tissues are lower, in comparison with the surgery performed in the control group. The bone fragments formed during implantation are mainly consolidated with each other and with the regenerating bone. Day 10 demonstrated that all animals with the use of MSC EVs had almost complete fusion of the screw device with the bone tissue, whereas after the operation without the application of MSC EVs, the heterogeneous histologic pattern was observed: From almost complete osseointegration of the implant to the absolute absence of contact between the foreign body and the new formed bone. Therefore, the use of MSC EVs during the introduction of dental implants into the proximal condyle of the tibia of rabbits contributes to an increase of the bone tissue density near the device after 3 days and to the achievement of consistently successful osseointegration of implants 10 days after the surgery. Full article

(This article belongs to the Special Issue Molecular Features of Growth Factors Applied to Tissue Engineering)

► Show Figures

Journal Menu

Journal Browser

Molecular Features of Growth Factors Applied to Tissue Engineering

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (3 papers)

Editorial

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI