Special Issue "New Advances in Inflammasomes"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 December 2023 | Viewed by 582
2. Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Rome, Italy
Interests: immunity; pathology; myasthenia gravis
Interests: autoimmunity; cancer; monoclonal gammopathy; minimal residual disease; biomarkers; other biological fluid; new technologies
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The increased morbidity and mortality due to the coronavirus disease 2019 in subjects with chronic conditions and a compromised immune system result from the host–coronavirus interaction, and inflammasomes have been proposed as important players. The activation of inflammasomes, which are multimeric protein complexes, is a crucial component of the innate immune response and is essential for the elimination of pathogens or damaged cells through the secretion of IL-1β and IL-18 and the induction of pyroptosis. However, the dysregulated activation of inflammasomes is involved in the pathogenesis of different autoimmune–autoinflammatory, neurodegenerative, and metabolic disorders that share the common line of inflammation in their pathogenetic fingerprint. Inhibition of inflammasome activation shows therapeutic effects and a wide range of anti-inflammatory compounds are currently being employed. This Special Issue is devoted to the most recent advances in the biology of inflammasomes and their engagement in human diseases.
Potential topics include, but are not limited to:
- Autoinflammatory diseases;
- Cardiovascular diseases;
- Neurodegenerative disorders;
- Mechanisms of action;
- Molecular targeting therapy.
Dr. Mariapaola Marino
Dr. Umberto Basile
Manuscript Submission Information
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- clinical perspectives
- nod like receptor protein 3
- inflammatory diseases
- biomarkers of inflammasome activation