Special Issue "The 25th Anniversary of NO"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 807
Special Issue Editors
Interests: hypoxia; hyperoxia; cardioprotection; brain protection; reoxygenation, molecular mechanisms; apoptosis; autophagy; erythropoietin; nitric oxide; animal models; exercise; high altitude; haemoglobin; oxygen carriers; blood oxygen transport
Special Issues, Collections and Topics in MDPI journals
Interests: free radical activity and heart metabolism, protection and development; stem cells and reparation of myocardial injuries; cardioprotection mechanisms of pre-and post-conditioning; effects of hydrogen sulphide and gasotransmitters in cardiovascular diseases; role of hydrogen sulphide in cell biology and physiology
Special Issue Information
Dear Colleagues,
A small molecule with myriad functions, nitric oxide (NO) today represents a nodal point of virtually all bodily functions. Initially identified as a toxic heme-protein ligand mainly derived from industrial chemistry, this small free radical was later recognised to be the most important gaseous signalling molecule and a key component of the endothelium-derived relaxing factor, a strong vasodilator first described as being synthesised in circulatory endothelial cells. The discovery of different isoforms of the enzyme that catalyses endogenous NO formation in various districts of the body, allowed for the deciphering of many functions in the nervous, immune and endocrine systems, in angiogenesis, blood oxygen transport and inflammation, just to name a few. In fact, up to 285,000 manuscripts related to NO have been published between 1815 and 2022, of these more than 220,000 were in the last 20 years only. Although the biological actions of NO were first glimpsed in the early 1990s thanks to Salvador Moncada, the surge of NO in its full potential may be dated to 1998 when the Nobel Prize in Medicine and Physiology was assigned to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad “for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system”. For the 25th anniversary of this worldwide recognition, the purpose of this Special Issue is to celebrate NO by gathering contributions from eminent scientists around the world, aiming at summarizing the various functions of NO in the body’s systems, as well as the biological and pharmacological targets of this pleiotropic molecule that paved the road to similar gaseous transmitters as carbon monoxide and hydrogen sulphide.
Prof. Dr. Michele Samaja
Prof. Dr. Daniele Mancardi
Guest Editors
Manuscript Submission Information
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Keywords
- nitric oxide
- gasotransmitter
- NO-synthase
- nitrosation
- nitrosylation
