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Special Issue "The 25th Anniversary of NO"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 807

Special Issue Editors

Department of Health Science, University of Milan, Via di Rudinì 8, I-20142 Milan, Italy
Interests: hypoxia; hyperoxia; cardioprotection; brain protection; reoxygenation, molecular mechanisms; apoptosis; autophagy; erythropoietin; nitric oxide; animal models; exercise; high altitude; haemoglobin; oxygen carriers; blood oxygen transport
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Department of Clinical and Biological Sciences, San Giovanni Bosco Hub Hospital, University of Turin, 10154 Turin, Italy
Interests: free radical activity and heart metabolism, protection and development; stem cells and reparation of myocardial injuries; cardioprotection mechanisms of pre-and post-conditioning; effects of hydrogen sulphide and gasotransmitters in cardiovascular diseases; role of hydrogen sulphide in cell biology and physiology

Special Issue Information

Dear Colleagues,

A small molecule with myriad functions, nitric oxide (NO) today represents a nodal point of virtually all bodily functions. Initially identified as a toxic heme-protein ligand mainly derived from industrial chemistry, this small free radical was later recognised to be the most important gaseous signalling molecule and a key component of the endothelium-derived relaxing factor, a strong vasodilator first described as being synthesised in circulatory endothelial cells. The discovery of different isoforms of the enzyme that catalyses endogenous NO formation in various districts of the body, allowed for the deciphering of many functions in the nervous, immune and endocrine systems, in angiogenesis, blood oxygen transport and inflammation, just to name a few. In fact, up to 285,000 manuscripts related to NO have been published between 1815 and 2022, of these more than 220,000 were in the last 20 years only. Although the biological actions of NO were first glimpsed in the early 1990s thanks to Salvador Moncada, the surge of NO in its full potential may be dated to 1998 when the Nobel Prize in Medicine and Physiology was assigned to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad “for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system”. For the 25th anniversary of this worldwide recognition, the purpose of this Special Issue is to celebrate NO by gathering contributions from eminent scientists around the world, aiming at summarizing the various functions of NO in the body’s systems, as well as the biological and pharmacological targets of this pleiotropic molecule that paved the road to similar gaseous transmitters as carbon monoxide and hydrogen sulphide.

Prof. Dr. Michele Samaja
Prof. Dr. Daniele Mancardi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nitric oxide
  • gasotransmitter
  • NO-synthase
  • nitrosation
  • nitrosylation

Published Papers (1 paper)

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The Effect of Aging on Nitric Oxide Production during Cerebral Ischemia and Reperfusion in Wistar Rats and Spontaneous Hypertensive Rats: An In Vivo Microdialysis Study
Int. J. Mol. Sci. 2023, 24(16), 12749; https://doi.org/10.3390/ijms241612749 - 13 Aug 2023
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Nitric oxide (NO) is involved in the pathogenesis of cerebral ischemic injury. Here, we investigated the effects of aging on NO production during cerebral ischemia-reperfusion (IR). Male Wister rats (WRs) were assigned to 12-month-old (older; n = 5) and 3-month-old (younger; n = [...] Read more.
Nitric oxide (NO) is involved in the pathogenesis of cerebral ischemic injury. Here, we investigated the effects of aging on NO production during cerebral ischemia-reperfusion (IR). Male Wister rats (WRs) were assigned to 12-month-old (older; n = 5) and 3-month-old (younger; n = 7) groups. Similarly, male spontaneous hypertensive rats (SHRs) were allocated to 12-month-old (older; n = 6) and 3-month-old (younger; n = 8) groups. After anesthesia, their NO production was monitored using in vivo microdialysis probes inserted into the left striatum and hippocampus. Forebrain cerebral IR injuries were produced via ligation of the bilateral common carotid arteries, followed by reperfusion. The change in the NO3 of the older rats in the SHR groups in the striatum was less compared to that of the younger rats before ischemia, during ischemia, and after reperfusion (p < 0.05). In the hippocampus, the change in the NO3 of the older rats in the SHR groups was lower compared to that of the younger rats after reperfusion (p < 0.05). There were no significant differences between the two WR groups. Our findings suggested that aging in SHRs affected NO production, especially in the striatum, before and during cerebral ischemia, and after reperfusion. Hypertension and aging may be important factors impacting NO production in brain IR injury. Full article
(This article belongs to the Special Issue The 25th Anniversary of NO)
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